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Method for preparing water-soluble florfenicol powder and prepared water-soluble florfenicol powder thereof

A technology of florfenicol powder and florfenicol, applied in medical preparations with non-active ingredients, medical preparations containing active ingredients, powder delivery, etc., can solve the problems of manpower, material resources and time, and achieve Simple process, saving manpower and material resources, easy to use

Active Publication Date: 2020-03-17
LUOYANG HUIZHONG ANIMAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The commonly used method for preparing clathrates is mainly saturated aqueous solution method, which involves heating clathrate, drying and other processes, but these methods require more manpower, material resources and time

Method used

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  • Method for preparing water-soluble florfenicol powder and prepared water-soluble florfenicol powder thereof
  • Method for preparing water-soluble florfenicol powder and prepared water-soluble florfenicol powder thereof
  • Method for preparing water-soluble florfenicol powder and prepared water-soluble florfenicol powder thereof

Examples

Experimental program
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Effect test

preparation Embodiment 1

[0033] The method for preparing water-soluble Florfenicol powder by mixing and pulverizing method of the present invention, the steps are as follows:

[0034](1) Take 10kg of florfenicol, 39.75kg of β-cyclodextrin, 50g of disodium salt of ethylenediaminetetraacetic acid, and 200g of sodium lauryl sulfate, and mix them in a mixer for 5 minutes to make a physical mixture.

[0035] (2) Put the physical mixture into a vibrating pulverizer to pulverize for 15 minutes to obtain water-soluble florfenicol powder.

[0036] (3) The ambient humidity of steps (1) and (2) is 40%RH-45%RH.

preparation Embodiment 2

[0038] The method for preparing water-soluble Florfenicol powder by mixing and pulverizing method of the present invention, the steps are as follows:

[0039] (1) Take 10kg of florfenicol, 39.75kg of β-cyclodextrin, 50g of disodium salt of ethylenediaminetetraacetic acid, and 200g of sodium lauryl sulfate, and mix them in a mixer for 5 minutes to make a physical mixture.

[0040] (2) Put the physical mixture into a vibrating pulverizer for pulverization, wherein the pulverization time is 15 minutes to obtain water-soluble florfenicol powder.

[0041] (3) The ambient humidity of steps (1) and (2) is 45%RH to 50%RH.

preparation Embodiment 3

[0043] The method for preparing water-soluble Florfenicol powder by mixing and pulverizing method of the present invention, the steps are as follows:

[0044] (1) Take 5kg of Florfenicol, 44.75kg of β-cyclodextrin, 62.5g of disodium salt of ethylenediaminetetraacetic acid, and 187.5g of sodium lauryl sulfate, and mix them in a mixer for 5 minutes to make a physical mixture .

[0045] (2) Put the physical mixture into a vibrating pulverizer for pulverization, wherein the pulverization time is 15 minutes to obtain water-soluble florfenicol powder.

[0046] (3) The ambient humidity of steps (1) and (2) is 40%RH-45%RH.

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Abstract

The invention provides a method for preparing water-soluble florfenicol powder. The method comprises the following steps: (1), taking raw materials including, by mass, 10 to 30w / w% of florfenicol, 69.5 to 89.5 w / w% of beta-cyclodextrin, and 0.5 w / w% of an absorption promoter, mixing the raw materials in a mixing machine for 5min to make a physical mixture; and (2), crushing the physical mixture obtained in the step (1) in a vibration crusher to obtain water-soluble florfenicol powder. The invention also provides water-soluble florfenicol powder prepared by the method. The maximum solubility offlorfenicol is 10000mg / L, which is equivalent to 200 times of the clinical use concentration; and the water-soluble florfenicol powder can be administrated by drinking water in a farm.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, in particular to a preparation method of water-soluble florfenicol powder and the prepared water-soluble florfenicol powder. Background technique [0002] Florfenicol (Florfenico1), also known as florfenicol, is the fluoride of thiamphenicol, which belongs to the broad-spectrum antibiotics of chloramphenicol for animals. It is developed by Schering-Plough Company of the United States. Chloramphenicol is similar to thiamphenicol, but its antibacterial activity is significantly better than that of chloramphenicol, and it has no side effects of aplastic anemia, and does not form cross-resistance with humans, so it has a wide range of clinical applications and is used for the treatment of Respiratory tract infection, typhoid fever, intestinal infection, etc. However, due to the poor water solubility of florfenicol, the dosage method is limited in clinical application, especially in large-scale int...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K47/18A61K47/20A61K47/69A61K31/165A61P31/04
CPCA61K9/0095A61K9/145A61K9/146A61K31/165A61K47/6951A61P31/04
Inventor 张许科张文君
Owner LUOYANG HUIZHONG ANIMAL MEDICINE
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