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Itching-relieving skin-care emulsifiable paste and preparation method thereof

A technology for skin care lotion and cream, which is used in skin care preparations, skin diseases, pharmaceutical formulations, etc. to achieve high biocompatibility, reduce irritation, and reduce diffusion barriers.

Active Publication Date: 2020-03-17
仁和全域(上海)大健康研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The technical problem to be solved by the present invention: In view of the many problems existing in the treatment of pruritus in the current antipruritic cream and the defects in the preparation of the antipruritic cream, the present invention provides an antipruritic skin care cream and its Preparation

Method used

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  • Itching-relieving skin-care emulsifiable paste and preparation method thereof
  • Itching-relieving skin-care emulsifiable paste and preparation method thereof
  • Itching-relieving skin-care emulsifiable paste and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0045] Embodiment 1: Prepare antipruritic skin care cream as follows

[0046] 1. Preparation and processing of raw materials:

[0047] The fruit seed oil is the mixture of dragon fruit seed oil, custard apple seed oil, kiwi fruit seed oil, and sea buckthorn fruit seed oil, and the weight ratio of dragon fruit seed oil: custard apple seed oil: kiwi fruit seed oil: sea buckthorn fruit seed oil is 1: 3:2:3;

[0048] The amino acid composition is composed of serine, leucine, proline, glycine and threonine, and the weight ratio of serine:leucine:proline:glycine:threonine is 1:1:3:2:5; The mushroom polysaccharide is extracted from shiitake mushrooms and Ganoderma lucidum, the weight ratio of Lentinan and Ganoderma lucidum polysaccharide is 3:7;

[0049] The emulsifier is composed of Tween and caprylic capric acid macrogol glyceride, the weight ratio of said Tween: caprylic capric acid macrogol glyceride is 1:4, and said Tween is Tween-40.

[0050] Preparation of microemulsion gel...

Embodiment 2

[0066] Embodiment 2: prepare antipruritic skin care cream as follows

[0067] 1. Preparation and processing of raw materials:

[0068] Fruit seed oil is that dragon fruit seed oil, custard apple seed oil are mixed by 1:2 weight ratio;

[0069]The amino acid composition is composed of serine, leucine, proline, glycine, and threonine, and the weight ratio of serine:leucine:proline:glycine:threonine is 1:1:1:1:1; The mushroom polysaccharide is extracted from Cordyceps sinensis; the nightshade is a dry product of the whole plant of Solanum solanum.

[0070] The emulsifier is composed of Tween and caprylic capric acid macrogol glyceride, the weight ratio of said Tween: caprylic capric acid macrogol glyceride is 1:6, and said Tween is Tween-80.

[0071] Preparation of microemulsion gel:

[0072] (a) Mix 5 parts of perilla oil, 10 parts of comfrey oil, 15 parts of chia seed oil, 25 parts of fruit seed oil, and 15 parts of avocado oil as the oil phase, and mix 25 parts of mangostee...

Embodiment 3

[0087] Embodiment 3: Prepare antipruritic skin care cream as follows

[0088] 1. Preparation and processing of raw materials:

[0089] The fruit seed oil is formed by mixing kiwi fruit seed oil and seabuckthorn fruit seed oil in a weight ratio of 3:5;

[0090] The amino acid composition is composed of serine, leucine, proline, glycine, and threonine, and the weight ratio of serine:leucine:proline:glycine:threonine is 1:2:3:2:1; The mushroom polysaccharide is extracted from Cicada fruticosa and Coprinus colliformis, and the weight ratio of Cicada polysaccharide to Cicada polysaccharide is 2:3; the solanum nigrum is the dried whole plant of Solanum solanum.

[0091] The emulsifier is composed of Tween and caprylic capric acid macrogolglycerides, the Tween:caprylic capric acid macrogolglycerides weight ratio is 1:5, and the Tween is Tween-60 and Tween -80 is mixed at a weight ratio of 1:1.

[0092] Preparation of microemulsion gel:

[0093] (a) Mix 3 parts of perilla oil, 7 p...

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Abstract

The invention discloses itching-relieving skin-care emulsifiable paste and a preparation method thereof. According to the preparation method, skin-moistening and itching-relieving components are extracted from a plurality of Chinese herbal medicines, various aromatherapy skin moistening substances are used, so that effective antioxidation is realized, the medicine is respectively subjected to micro-emulsion gel and liposome micro-capsule coating according to different purposes, the pH value is 5.8 to 6.5, the itching-relieving skin-care emulsifiable paste comprise 65-75wt% of micro-emulsion gel and 25-35wt% of liposome micro-capsules, the liposome micro-capsules contain an itching relieving traditional Chinese medicine liquid and have diameters of 250-350nm, the micro-emulsion gel comprises a micro-emulsion with the particle size of 30-90nm, the optimized emulsifiable paste improves the 24-hour transdermal absorption rate to 68% or above, the intradermal drug retention amount can reach4mg or above within 24h, skin moistening and itching relieving components can be effectively delivered into the skin, dryness and allergic pruritus are inhibited, the skin of the pruritus part is repaired from outside to inside, itching can be rapidly relieved, the drug effect lasting time is long, and pruritus recurrence is inhibited.

Description

technical field [0001] The invention relates to the field of skin care cream processing, in particular to an antipruritic skin care cream and a preparation method thereof. Background technique [0002] Microemulsion is a spontaneous colloidal solution composed of oil phase, water phase, surfactant and co-surfactant. Different from ordinary emulsion, microemulsion is a clear and transparent solution, because the particle size of microemulsion is in the range of 10-100nm, and the particle size in this range cannot be recognized by naked eyes. Different from the suspension, the microemulsion system is an isotropic thermodynamically stable system. The physical and chemical properties of the microemulsion are the same in all directions, and at a certain temperature, the microemulsion will exist stably without demulsification. The formation of microemulsion is a spontaneous process, that is, the components of microemulsion are mixed together and then given a slight external force...

Claims

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Application Information

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IPC IPC(8): A61K8/9794A61K8/9789A61K8/92A61K8/73A61K8/06A61K8/11A61Q19/00A61Q19/08A61P17/04
CPCA61K8/9794A61K8/9789A61K8/922A61K8/73A61K8/068A61K8/11A61Q19/00A61Q19/08A61P17/04A61K2800/524
Inventor 鲍芳丽孙冬梅范彩云孙有俊
Owner 仁和全域(上海)大健康研究院有限公司
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