Application of peony seed oil in preparation of drugs and health food for improving male bone biomechanical properties

A kind of peony seed oil, biomechanical technology, applied in the application field of medicine and health food, can solve the problems of increasing hemoglobin and hematocrit, testosterone replacement therapy has more advantages than disadvantages, bone health is not recommended, etc.

Inactive Publication Date: 2020-03-13
GUANGDONG MEDICAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although testosterone replacement therapy can increase bone mineral density, the routine use of testosterone or other androgen replacement therapy to improve bone health is not recommended at present, and the value of androgen replacement therapy in the prevention and treatment of male osteoporosis still needs more comprehensive clinical evaluation
It is also worth noting that there may also be potential risks in testosterone supplementation therapy, such as increasing hemoglobin and hematocrit, reducing high-density lipoprotein, etc.
Current research has not yet provided sufficient evidence to clearly prove that the benefits of testosterone replacement therapy outweigh the risks

Method used

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  • Application of peony seed oil in preparation of drugs and health food for improving male bone biomechanical properties
  • Application of peony seed oil in preparation of drugs and health food for improving male bone biomechanical properties
  • Application of peony seed oil in preparation of drugs and health food for improving male bone biomechanical properties

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Peony seed oil soft capsule: select peony seed oil that can be used as food or medicine with a purity that meets the requirements, add an appropriate amount of stabilizer, antioxidant, suspending agent, and emulsifier according to the formula of the soft capsule to prepare the content of the soft capsule, and then According to the production process of the soft capsule, each capsule contains 1g-2g of peony seed oil.

[0012] The peony seed oil of the present invention can also be prepared into hard capsules, tablets, granules, oral liquids or beverages by adding corresponding pharmaceutical excipients according to the needs of clinical application.

[0013] Experimental study on the protective effect of Peony Seed Oil Soft Capsules on the decrease of bone biomechanical function and osteoporosis in testicle-removed mice: In order to prove that Peony Seed Oil can replace testosterone as a drug for male osteoporosis patients, we used the method of testicle removal, Establi...

Embodiment 2

[0027] According to the experimental results of Example 1, we designed to add calcium carbonate and vitamin D3 to peony seed oil to form a group of health food with better curative effect and suitable for various types of osteoporosis people. The calcium agent supplemented by peony seed oil can be calcium carbonate, calcium lactate, calcium citrate and calcium gluconate, active calcium and amino acid chelated calcium; vitamin D can be vitamin D, vitamin D 2 , vitamin D 3 , calcitriol and alfacalcidol. The best product proposed by the present invention is composed of peony seed oil, calcium carbonate and vitamin D 3 Composition, its formula and production process are as follows.

[0028] Peony seed oil vitamin D calcium soft capsule: choose peony seed oil that can be used as food or medicine with a purity that meets the requirements, and each 1000 capsules contains 1kg~2kg of peony seed oil, vitamin D 3 4 ~ 10mg, calcium carbonate 0.5 ~ 1.0kg to prepare the formula of soft c...

Embodiment 3

[0030]According to the experimental results of Example 1, we designed a new anti-osteoporosis compound by adding estrogen drugs to peony seed oil. These compound preparations can be used to prevent and treat postmenopausal osteoporosis in women, especially It is used to prevent bone loss in female postmenopausal osteoporosis patients, and it also has a good preventive and therapeutic effect on the menopausal syndrome associated with these patients. The estrogen that can be added in peony seed oil mentioned in the present invention refers to estradiol, estrone, diethylstilbestrol, ethinyl estradiol, nylestriol, tibolone (Live Love) and premarin ( Premarin). The compound preparation made of peony seed oil and these estrogens, the content of each capsule is 1 / 3 to 1 / 2 of the dose of these estrogens medicinal preparations. The formula and production technology of the best product proposed by the present invention are as follows:

[0031] Peony seed oil estrogen soft capsules: ch...

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Abstract

With the increase of age, the testosterone level of middle-aged and elderly men gradually decreases, the bone biomechanical properties decrease, and fracture and osteoporosis are easy to occur. Testosterone deficiency is believed to be one of the main causes of osteoporosis in men. Our research found that peony seed oil has the same effect as testosterone, has a certain antagonistic effect on thedecrease of bone biomechanical properties and osteoporosis caused by testis-removed mice. The peony seed oil provided by the invention can be made into soft capsules, hard capsules, tablets, granules,oral liquids and beverages that can be used for clinical application, and is used for preventing and treating male osteoporosis patients and people whose bone biomechanical properties are reduced dueto various reasons. The invention also discloses formulas and preparation technologies of peony seed oil soft capsules, peony seed oil vitamin D calcium soft capsules, peony seed oil estrogen soft capsules and peony seed oil aspirin soft capsules, which have good effects of preventing and treating low bone biomechanical function and osteoporosis of various populations.

Description

technical field [0001] The invention belongs to the technical field of health food and medicine production, and specifically relates to the application of peony seed oil in the preparation of medicine and health food for improving the biomechanical properties of male bones. Background technique [0002] Osteoporosis (OP) is a systemic disease characterized by decreased bone mass and microstructural destruction of bone tissue, leading to decreased bone biomechanical properties, increased bone fragility, and increased risk of fractures and related complications. sexual bone disease. Compared with women, osteoporosis in men is often neglected, a large number of patients are not diagnosed and treated in time, and the mortality rate of osteoporotic fractures is also higher than that of women. As the age increases, the testosterone level of middle-aged and elderly men gradually decreases, and testosterone deficiency occurs. The traditional view is that osteoporosis in elderly me...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K36/65A61K45/06A61K9/48A61P19/10A61P15/12A23L33/115A23L33/16A23L33/165A23L33/155A61K31/593A61K33/10A61K31/616
CPCA23V2002/00A61K9/48A61K31/593A61K31/616A61K33/10A61K36/65A61K36/71A61K45/06A23L33/115A23L33/155A23L33/16A23L33/165A61P15/12A61P19/10A61K2300/00A23V2200/306A23V2250/18A23V2250/7106A23V2250/1578
Inventor 崔燎吴铁王可欣陈彩玲郑晓艳林振波许碧莲
Owner GUANGDONG MEDICAL UNIV
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