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Preparation method and application of stachydrine ionic liquid

The technology of ionic liquid and stachydine is applied in the field of preparation of stachydrine organic acid ionic liquid, which can solve the problems of difficult separation of precipitated salts, easy water separation of stachydrine, etc., and achieves good extraction effect and transdermal absorption effect. Good, high-purity effect

Pending Publication Date: 2020-03-06
珠海中科先进技术研究院有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to provide a preparation method of stachydrine ionic liquid, which solves the problems that stachydrine ionic liquid precipitation salt is difficult to separate by salting out method and precipitation method, and stachydrine is weakly alkaline and easy to be separated by water. The method is efficient and easy to use in industrial processes

Method used

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  • Preparation method and application of stachydrine ionic liquid
  • Preparation method and application of stachydrine ionic liquid
  • Preparation method and application of stachydrine ionic liquid

Examples

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Effect test

Embodiment 1

[0028] Weigh 0.10mol stachydrine hydrochloride and 0.15mol salicylic acid and dissolve them in 100mL of distilled water respectively, then pass the stachydrine hydrochloride solution through a chromatographic column equipped with 800g pretreated strong basic anion exchange resin to make the solution Pass through the chromatography column at a flow rate of 20m / h. The passed solution was mixed with the salicylic acid solution, and the mixed solution was vacuum-dried at 0.1 mPa and 60°C for 48 hours to finally obtain the stachydrine-salicylic acid ionic liquid [Sta][Sal].

Embodiment 2

[0030] Weigh 0.10mol stachydrine hydrochloride and 0.10mol rhododendronic acid and dissolve them in 100mL distilled water acetonitrile respectively, then pass the stachydrine hydrochloride solution through the chromatographic column of 100g pretreated strong basic anion exchange resin to make The solution was passed through the chromatography column at a flow rate of 15 m / h. The passed solution was mixed with the rhododendronic acid solution, and the mixed solution was evaporated to dryness at 60° C. until the weight did not change, and finally the stachydrine-rhodododric acid ionic liquid [Sta][Aze] was obtained.

Embodiment 3

[0032] Weigh 0.10mol stachydrine hydrochloride and 0.30mol acetic acid and dissolve them in 100mL ethanol respectively, then pass the stachydrine hydrochloride solution through the chromatographic column of 350g pretreated strong basic anion exchange resin, and make the solution dilute at 10mL / h flow through the column. The passed solution was mixed with acetic acid solution, and the mixed solution was rotary evaporated at 30° C. until no condensate was produced, and stachydrine-acetic acid ionic liquid [Sta][Ace] was finally obtained.

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Abstract

The invention discloses a preparation method and application of a stachydrine ionic liquid, and belongs to the technical field of materials. The preparation method comprises the steps: dissolving stachydrine hydrochloride and organic acid in solvents separately, treating the obtained stachydrine hydrochloride solution through ion exchange resin, mixing the treated liquid with the obtained organicacid solution directly, performing a neutralization reaction, and finally performing treatment through a solvent removal process so as to obtain the stachydrine organic acid ionic liquid. The synthesis method has a simple process, environmental protection and easy promotion, the synthesized ionic liquid has high purity and degradability, the problems of toxic residual and emission pollution of traditional solvents are solved, and the method has application prospects in extraction, medicine, food, cosmetics and other fields.

Description

technical field [0001] The invention belongs to the technical field of synthesis of biological ionic liquids, and relates to a preparation method and application of stachydrine organic acid ionic liquids. Background technique [0002] Stachydrine is one of the main alkaloids of plants of the genus Leonurus Linn. in the Labiatae family, accounting for 0.09-1.01% of the total mass of Motherwort plants. Studies have shown that in addition to treating gynecological diseases such as uterine bleeding and abnormal uterine contraction, stachydrine also has therapeutic effects on cardiovascular diseases, can reduce the damage of human umbilical vein endothelial cells caused by hypoxia and reoxygenation, and improve the endothelial cells induced by high glucose. Aging, treatment of heart hypertrophy caused by various reasons, etc. In addition, stachydrine also has the effect of inhibiting inflammation and oxidative stress, and has certain anti-tumor activity. A commercially availabl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D207/16C07C51/41C07C65/10C07C55/18C07C53/10C07C65/05C07C59/105C07C67/00C07C69/157B01D11/02
CPCB01D11/0288C07C51/412C07C67/00C07D207/16C07C65/10C07C55/18C07C53/10C07C65/05C07C59/105C07C69/157
Inventor 张嘉恒余明远王岩费玉清闫修瑜陈正件张晃淳
Owner 珠海中科先进技术研究院有限公司
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