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Composite material carrying Cu2O-CuO nanowire array and preparation method thereof, biosensor and application thereof

A nanowire array and biosensor technology, which is applied in the direction of chemical reaction of materials for analysis, chemiluminescence/bioluminescence, and analysis of materials, can solve the problems of low Tyr homology, quantitative detection, insensitivity, etc. Achieve the effects of reducing photogenerated electron-hole recombination rate, good selectivity, and high active site density

Active Publication Date: 2020-02-28
QUFU NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method is relatively insensitive and cannot quantitatively detect
ELISAF method is sensitive to detect Tyr antibody, but the Tyr of the mushroom used has low homology with human Tyr

Method used

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  • Composite material carrying Cu2O-CuO nanowire array and preparation method thereof, biosensor and application thereof
  • Composite material carrying Cu2O-CuO nanowire array and preparation method thereof, biosensor and application thereof
  • Composite material carrying Cu2O-CuO nanowire array and preparation method thereof, biosensor and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Take the foamed copper and cut it into 2*4cm with scissors 2 The tablets are then sonicated with dilute hydrochloric acid for 1-2 minutes. Rinse it with deionized water. Use an analytical balance to weigh 3.204g of sodium hydroxide and dissolve it in 15mL of water. Weigh 0.89g of ammonium persulfate and dissolve in 15mL of water. Mix the dissolved sodium hydroxide solution with the ammonium persulfate solution. Then put the foamed copper sheet sonicated with dilute hydrochloric acid into the mixed solution and let it stand for reaction for 20 minutes. After the reaction is completed, the foamed copper sheet is taken out, rinsed with deionized water, and dried in an oven to be loaded with Cu 2 Composite material of O-CuO nanowire array;

[0025] (2) Load the Cu obtained in step (1) 2 The composite material of the O-CuO nanowire array is annealed in a tube furnace, and the annealing process is 2℃min -1 The heating rate is increased to 350℃, and the holding time is 15min, ...

Embodiment 2

[0027] Cut the composite material prepared in Example 1 into 0.5*1.0cm 2 , Fixed with raw tape, its area is 0.5*0.5cm 2 . Use a 50μL pipette to drop 0.25wt% chitosan solution to a fixed area of ​​Cu 2 On the O-CuO nanowire array, the electrode was dried at room temperature. The electrode was placed in a 2mL centrifuge tube containing 100μL Tyr, 100μL tyrosine and 100μL deionized water and incubated for 1.5h to obtain a signal-enhanced detection of Tyr. biological sensor.

[0028] figure 1 To prepare composite materials (Cu 2 O / CuO NA / CF) experimental principle diagram for detecting Tyr. As shown in the figure, a three-dimensional Cu is synthesized 2 O-CuO nanowire array composite material. Because chitosan has good adhesion, after dropping chitosan, chitosan will adhere to Cu 2 O-CuO nanowire array on the electrode surface. Cu deposited with chitosan 2 The O-CuO nanowire array is incubated in Tyr and tyrosine incubation solution. According to Cu 2 The band diagram of O-CuO, un...

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Abstract

The invention belongs to the field of new nanomaterials, and in particular relates to a composite material carrying a Cu2O-CuO nanowire array and a preparation method thereof, a biosensor and application thereof. The invention uses copper foam as a substrate to prepare a Cu(OH)2 nanowire array by a room-temperature solvent-heat method, and prepares a three-dimensional composite material loaded with the Cu2O-CuO nanowire array by annealing in air by precisely controlling time and temperature. The preparation method is simple and easy to operate. CuO will consume the electrons on the Cu2O conduction band by the composite material under light to reduce the photo-generated electron-hole recombination rate. As a three-dimensional electrode, the Cu2O-CuO nanowire array has a large surface area,high active site density and low series resistance, which is conducive to the generation of optoelectronic signals. The biosensor made of the composite material is used for the detection of tyrosinase.

Description

Technical field [0001] The invention belongs to the field of nano new materials, and specifically relates to a Cu 2 Composite material of O-CuO nanowire array and preparation method thereof, biosensor and application thereof. Background technique [0002] Cu 2 O is a p-type semiconductor with a narrow band gap of 2.0-2.2eV and a controllable morphology. Because of its advantages in reasonable price, environmental friendliness, sufficient reserves and unique optical and electrical properties, it has been used in many fields, including lithium ion batteries, super capacitors, CO 2 Photocatalytic reduction, photocatalytic degradation and photoelectrochemical sensors. However, Cu 2 O has the disadvantage of a high recombination rate of photogenerated electron-hole pairs. [0003] Tyrosinase is a copper-containing enzyme derived from embryonic nerve cells and is a key enzyme for melanin metabolism and catecholamines. There are many methods to detect Tyr, such as immunoblotting to dete...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/327G01N21/76
CPCG01N27/327G01N21/76
Inventor 渠凤丽吴静华
Owner QUFU NORMAL UNIV
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