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Skin softener containing cannabidiol nano liposomes and preparation method thereof

A technology of cannabidiol nano and liposomes, which is applied in skin care preparations, pharmaceutical formulas, cosmetic preparations, etc., can solve problems such as insecurity and skin allergies, achieve long-lasting efficacy, increase bioavailability, and appearance Clear and transparent effect

Inactive Publication Date: 2020-02-28
YUNNAN LVXIN BIOLOGICAL PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention, on the one hand, is to solve the problems of skin allergies and unsafety caused by the presence of alcohol, pigments, hormones, etc. in lotion water on the market; The problem is to provide a lotion containing cannabidiol nano-liposomes and a preparation method. The prepared cannabidiol liposomes are clear and transparent after being dissolved in water, without precipitation or CBD crystallization; the lotion Not only has good moisturizing effect, but also has multiple skin care effects such as antibacterial and anti-inflammatory, anti-acne and soothing, anti-oxidation, etc.

Method used

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  • Skin softener containing cannabidiol nano liposomes and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) The preparation of cannabidiol nanoliposomes comprises the following steps:

[0034] ①Preparation of the organic phase: Accurately weigh 10 mg of cannabidiol, 300 mg of phospholipids and 100 mg of cholesterol and add them to ethanol, heat and stir to fully dissolve to obtain an organic phase.

[0035] ② Film production: Evaporate the organic phase obtained in step ① on a rotary evaporator to remove the solvent, so that the residue forms a phospholipid film on the inner wall of the container. The rotary evaporation temperature is 50 ° C and the vacuum degree is 0.1 MPa.

[0036] ③Hydration: Slowly add 20ml of 0.02mol / L phosphate buffer (pH8.0) to the phospholipid film container, and continue rotary steaming for 3 hours to make the phospholipid film fall off and obtain cannabidiol liposome suspension.

[0037] ④ Homogenization: inject the suspension into a high-pressure homogenizer for 3 times for homogenization, the homogenization pressure is 40MPa, after homogenizat...

Embodiment 2

[0045] (1) The preparation of cannabidiol nanoliposomes comprises the following steps:

[0046]①Preparation of the organic phase: Accurately weigh 10 mg of cannabidiol, 200 mg of phospholipids and 50 mg of cholesterol and add them to ethanol, heat and stir to fully dissolve to obtain an organic phase.

[0047] ② Film production: Evaporate the organic phase obtained in step ① to remove the solvent on a rotary evaporator, so that the residue forms a phospholipid film on the inner wall of the container. The rotary evaporation temperature is 40 ° C and the vacuum degree is 0.2 MPa.

[0048] ③Hydration: Slowly add 15ml of 0.01mol / L phosphate buffer (pH7.0) into the phospholipid film container, and continue rotary steaming for 2 hours to make the phospholipid film fall off to obtain cannabidiol liposome suspension.

[0049] ④ Homogenization: Inject the above suspension into a high-pressure homogenizer for 2 times for homogenization, the homogenization pressure is 20MPa, after homoge...

Embodiment 3

[0057] (1) The preparation of cannabidiol nanoliposomes comprises the following steps:

[0058] ①Preparation of the organic phase: Accurately weigh 10 mg of cannabidiol, 100 mg of phospholipid and 20 mg of cholesterol and add them to ethanol, heat and stir to fully dissolve to obtain the organic phase.

[0059] ② Film production: Evaporate the organic phase obtained in step ① on a rotary evaporator to remove the solvent, so that the residue forms a phospholipid film on the inner wall of the container. The rotary evaporation temperature is 40 ° C and the vacuum degree is 0.1 MPa.

[0060] ③Hydration: Slowly add 10ml of 0.01mol / L phosphate buffer (pH6.5) into the phospholipid film container, and continue rotary steaming for 1 hour to make the phospholipid film fall off to obtain cannabidiol liposome suspension.

[0061] ④ Homogenization: inject the above suspension into a high-pressure homogenizer for 3 times for homogenization, the homogenization pressure is 30MPa, after homoge...

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Abstract

The invention discloses a skin softener containing cannabidiol nano liposomes and a preparation method thereof; the skin softener is characterized by comprising, by mass, 0.1-1% of cannabidiol nano liposomes, 5-10% of glycerol, 0.5-3% of hyaluronic acid, 0.1-1% of ceramide, 1-5% of trehalose, 0.001-0.01% of phenoxyethanol, and deionized water. Cannabidiol (CBD) has many physiological effects, suchas antibacterial and anti-inflammatory effects, anti-acne effect and anti-oxidation effect, but is insoluble in water, which limits its application and bioavailability. The fat-soluble CBD is made into the nano cannabidiol liposomes, so that the water solubility and stability of the CBD are improved, the transdermal absorption effect of the CBD is promoted, the CBD penetrates the skin surface quickly and effectively and reaches the deep layer of the skin to slowly release, and the efficacy of the CBD is longer. The skin softener according to the invention is clear and transparent in appearance, free of precipitation or CBD crystal precipitation and free of alcohol, hormone, pigment, essence and other components, has a soft and safe formulation, and has the multiple effects of efficient moisture preservation, antibiosis and anti-inflammation, acne relief, oxidation resistance and the like.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and in particular relates to a lotion containing cannabidiol nano liposome and a preparation method. Background technique [0002] Emollient lotion is a low-viscosity, liquid skin care cosmetic that flows as easily as water. Its most primitive and basic function is to replenish and maintain the moisture required by human skin. However, with the needs of consumers at different levels, people are not satisfied with the moisturizing effect of lotion only, but also need to have other skin care and nourishing effects, such as anti-inflammatory, anti-acne, soothing, whitening, anti-wrinkle, repairing, etc. At the same time, the ingredients used are safe and have no side effects. [0003] Due to the important pharmacological and physiological activities of its active component cannabinoids, cannabis has been paid more and more attention by the world. So far, more than 100 plant-derived cannabinoids h...

Claims

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Application Information

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IPC IPC(8): A61K8/14A61K8/34A61K8/42A61K8/60A61K8/73A61Q19/00A61Q19/08
CPCA61K8/14A61K8/34A61K8/345A61K8/347A61K8/42A61K8/60A61K8/735A61Q19/00A61Q19/08
Inventor 刘胜贵王钲霖薛红芬付彬彬李智高孔令羽
Owner YUNNAN LVXIN BIOLOGICAL PHARMA CO LTD
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