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Application of Losartan in preparation of antineoplastic drugs

An anti-tumor drug, losartan technology, applied in the field of anti-tumor drugs, can solve problems affecting the prognosis of patients, achieve the effect of preventing cancer recurrence and prolonging cancer survival

Pending Publication Date: 2020-02-21
天津贝罗尼生物科技有限公司
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  • Summary
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AI Technical Summary

Problems solved by technology

Although these side effects are within the acceptable risk range as part of cancer treatment, they can have a significant impact on the patient's quality of life and normal treatment progression when receiving other available chemotherapy, thereby affecting the patient's overall prognosis
This also means that the current anti-cancer chemotherapy can only be used for a limited period of time before the patient needs to recover

Method used

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  • Application of Losartan in preparation of antineoplastic drugs
  • Application of Losartan in preparation of antineoplastic drugs
  • Application of Losartan in preparation of antineoplastic drugs

Examples

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Embodiment Construction

[0018] The present invention will be further described in detail below through the specific examples, the following examples are only descriptive, not restrictive, and cannot limit the protection scope of the present invention with this.

[0019] figure 1 As shown, flusartan is an antihypertensive drug of the angiotensin II receptor blocker (ARB) class. Flusartan blocks angiotensin II, a key hormone in the body that regulates blood pressure. Flusartan can specifically antagonize the binding of angiotensin II and angiotensin II AT1 receptors, blocking the arterial vasoconstriction, sympathetic nerve excitation and baroreceptor induced by angiotensin II (ANG II) in the circulation and local tissues Increased sensitivity and other effects, strong and sustained reduction in blood pressure, systolic and diastolic blood pressure decreased. It can still reduce left ventricular hypertrophy, inhibit myocardial cell proliferation, delay or reverse myocardial remodeling, and improve le...

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Abstract

The invention discloses application of Losartan in preparation of antineoplastic drugs. According to the application of the Losartan in preparation of the antineoplastic drugs, the Losartan is used for inhibiting binding of angiotensin II (Ang II) and Ang II subtype-1 receptors; and the Losartan is responsible for initiating most renin angiotensin system (RAS) related activities, including angiogenesis, cell proliferation and migration. Therefore, the Losartan is capable of inhibiting activities, including angiogenesis, cell proliferation and the like, in tumor cells and peripheral tumor fields, thereby directly and indirectly inhibiting tumor cell growth in a bilateral way (by reducing oxygen supply and nutrient supply).

Description

technical field [0001] The invention relates to antitumor drugs, in particular to the application of losartan in the preparation of antitumor drugs. Background technique [0002] Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (vascular permeability factor, VPF), is a highly specific factor that promotes the growth of vascular endothelial cells. Matrix degeneration, vascular endothelial cell migration, proliferation and angiogenesis. Controlling tumor growth by inhibiting angiogenesis, which prevents cancer cells from growing and spreading, has long been explored in cancer biology. [0003] Because cancer cell proliferation requires a "vascular phenotype" switch and increased production of a number of angiogenic factors, including vascular endothelial growth factor (VEGF) and factors that stimulate VEGF. The angiotensin system (RAS) is such a system and is involved in blood pressure regulation. The combination of angiotensin II (Ang I...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4178A61P35/00
CPCA61K31/4178A61P35/00
Inventor 王予
Owner 天津贝罗尼生物科技有限公司
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