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Double-loaded nano pesticide sustained-release capsule for preventing and curing rice sheath blight disease and preparation method of double-loaded nano pesticide sustained-release capsule

A rice sheath blight and nano-pesticide technology, applied in the field of pesticides, can solve the problems of pesticide loss, loss of effective components, and increase in agricultural production costs.

Active Publication Date: 2020-02-14
INST OF ENVIRONMENT & SUSTAINABLE DEV IN AGRI CHINESE ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The control of rice sheath blight has mainly relied on Jinggangmycin for many years, but the control effect of using Jinggangmycin has generally declined in recent years
In addition, when traditional pesticide formulations are used to control rice sheath blight, the active ingredients of pesticides will be lost due to wind, sun, and rain during field application, and the effective utilization rate is about 36%. The utilization rate of the final pest target is insufficient. 0.1%, not only increases the cost of agricultural production, but also the loss of pesticides to non-target areas, causing certain food safety and ecological environment problems
However, the current pesticide sustained-release capsules are mostly concentrated at the micron level. Nano-scale pesticide sustained-release capsules have obvious advantages in improving the deposition and distribution of pesticide leaves and enhancing biological activity due to their small size effect and large specific surface area. The preparation process of high-grade pesticide capsules is relatively high, especially the research on dual-loaded nano-pesticide sustained-release capsules loaded with two pesticide active ingredients at the same time is very limited.

Method used

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  • Double-loaded nano pesticide sustained-release capsule for preventing and curing rice sheath blight disease and preparation method of double-loaded nano pesticide sustained-release capsule
  • Double-loaded nano pesticide sustained-release capsule for preventing and curing rice sheath blight disease and preparation method of double-loaded nano pesticide sustained-release capsule
  • Double-loaded nano pesticide sustained-release capsule for preventing and curing rice sheath blight disease and preparation method of double-loaded nano pesticide sustained-release capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0126] The preparation of embodiment 1 double-loaded nanopesticide sustained-release capsule powder 1

[0127] Dissolve 2.5g of Jinggangmycin in 15ml of water to obtain the inner water phase, dissolve 0.5g of thifluzamide in 60ml of organic solvent dichloromethane, add 3g of polylactic acid, the capsule wall material, to obtain the oil phase, and use an ultrasonic pulverizer at 585W Add the inner water phase dropwise to the oil phase, ultrasonically emulsify for 5min to obtain a W / O emulsion; dissolve 4g emulsifier (1.34g polyvinyl alcohol and 2.66g polycarboxylate) in 300ml water to obtain the outer water phase, use Add the obtained W / O emulsion into the external water phase dropwise at 19000rpm by a high-pressure shearing machine, and shear and emulsify for 5 minutes to obtain a W / O / W initial emulsion.

[0128] Using a high-pressure homogenizer to homogenize the W / O / W primary emulsion under high pressure at 900 Pa for 15 minutes to obtain a miniemulsion, wherein the droplet ...

Embodiment 2

[0131] The preparation of embodiment 2 double-loaded nanopesticide sustained-release capsule water suspension 2

[0132] Dissolve 2.5g of Jinggangmycin in 15ml of water to obtain the inner water phase, dissolve 0.5g of thifluzamide in 60ml of organic solvent dichloromethane, add 3g of polylactic acid, the capsule wall material, to obtain the oil phase, and use an ultrasonic pulverizer at 585W Add the inner water phase dropwise to the oil phase, ultrasonically emulsify for 5min to obtain a W / O emulsion; dissolve 4g emulsifier (1.34g polyvinyl alcohol and 2.66g polycarboxylate) in 300ml water to obtain the outer water phase, use Add the obtained W / O emulsion into the external water phase dropwise at 19000rpm by a high-pressure shearing machine, and shear and emulsify for 5 minutes to obtain a W / O / W initial emulsion.

[0133] Using a high-pressure homogenizer to homogenize the W / O / W primary emulsion under high pressure at 900 Pa for 15 minutes to obtain a miniemulsion, wherein th...

Embodiment 3

[0136] Preparation of Example 3 Double-loaded Nano Pesticide Sustained Release Capsule Powder 3

[0137] Dissolve 2.4g Jinggangmycin in 50ml water to obtain the inner water phase, dissolve 0.4g thifluzamide in 50ml organic solvent dichloromethane, add 2.4g polylactic acid, the capsule wall material, to obtain the oil phase, and use an ultrasonic pulverizer to Add the inner water phase dropwise to the oil phase at 585W, and ultrasonically emulsify for 4min to obtain a W / O emulsion; dissolve 4.5g emulsifier (1.5g polyvinyl alcohol and 3.0g polycarboxylate) in 300ml water to obtain the outer water phase , using a high-pressure shearing machine to drop the obtained W / O emulsion into the external water phase at 19000 rpm, and shear and emulsify for 8 minutes to obtain a W / O / W emulsion.

[0138] The above-mentioned W / O / W primary emulsion was homogenized under high pressure at 900 Pa for 18 minutes by a high-pressure homogenizer to obtain a miniemulsion, wherein the droplet size of t...

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Abstract

The invention provides a double-loaded nano pesticide sustained-release capsule for preventing and curing rice sheath blight disease and a preparation method of the double-loaded nano pesticide sustained-release capsule. The double-loaded nano pesticide sustained-release capsule is prepared from the following components by weight: 2.1-2.5 parts of validamycin, 0.3-0.5 part of thifluzamide, 2.4-4 parts of capsule wall materials, 45-70 parts of organic solvent, 3-5 parts of an emulsifier, 225-350 parts of water, 15-150 parts of excipient and 0-10 parts of adjuvant; and the weight ratio of the validamycin to the thifluzamide is (5 to 1)-(7 to 1). The double-loaded nano pesticide sustained-release capsule is small in particle size, good in particle dispersibility, excellent in sustained-release performance, high in effective utilization rate, good in prevention and control effect on the rice sheath blight disease and simple in preparation process, and industrialization is facilitated.

Description

technical field [0001] The invention belongs to the technical field of pesticides. Specifically, the present invention relates to a double-loaded nano-pesticide sustained-release capsule for preventing and treating rice sheath blight and a preparation method thereof. Background technique [0002] Rice sheath blight is one of the most widely distributed and harmful rice diseases in the world, and it has risen to the top of the three major rice diseases in my country. The control of rice sheath blight has mainly relied on Jinggangmycin for many years, but the control effect of using Jinggangmycin has generally declined in recent years. In addition, when traditional pesticide formulations are used to control rice sheath blight, the active ingredients of pesticides will be lost due to wind, sun, and rain during field application, and the effective utilization rate is about 36%. The utilization rate of the final pest target is insufficient. 0.1%, not only increases the cost of ...

Claims

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Application Information

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IPC IPC(8): A01N25/28A01N43/16A01N47/02A01P1/00
CPCA01N25/28A01N43/16A01N47/02
Inventor 王琰崔海信崔建霞申越张燕卿
Owner INST OF ENVIRONMENT & SUSTAINABLE DEV IN AGRI CHINESE ACADEMY OF AGRI SCI
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