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High-quality curcumin product as well as production method and application thereof

A technology of curcumin and curcumin extract, applied in the field of high-quality curcumin products, can solve the problem of improving solvent residue and crystal bulk density, fluidity, affecting crystal physicochemical properties, undisclosed crystallization process crystal product physicochemical properties, etc. problems, to achieve the effects of easy large-scale production, improved fluidity, and reduced solvent residues

Active Publication Date: 2020-02-11
CHENGUANG BIOTECH GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, these existing technologies have not investigated or optimized the heating temperature, cooling temperature, stirring speed and other processes in the crystallization process, and the formation of crystals is usually greatly disturbed by external factors, and various parameters of crystallization conditions may affect the crystallization process. The physical and chemical properties of the crystallization process, which specific parameters in the crystallization process have no specific impact on the solvent residue and the physical and chemical properties of the crystal product in the prior art, and have not solved the technical problems of improving the solvent residue in the crystallization and the bulk density and fluidity of the crystal

Method used

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  • High-quality curcumin product as well as production method and application thereof
  • High-quality curcumin product as well as production method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Dissolving: get 100 g of turmeric extract raw material whose solvent residue is 5% (mass fraction), add 100 ml of n-butanol, heat up to 115° C., stir and dissolve;

[0041]Reflux: Introduce carbon dioxide at 117°C, and start to cool down after reflux for 0.5h;

[0042] Cooling and crystallization: the refluxed solution is cooled and stirred for crystallization, the stirring speed is 100r / min, and the temperature is lowered to 40°C and then kept for 48h;

[0043] Separation and drying: After the crystallized feed liquid is suction-filtered, the curcumin crystal semi-finished product is obtained, and the curcumin crystal semi-finished product is dried to obtain high-quality curcumin.

[0044] Through the production method of above-mentioned high-quality curcumin, the curcumin that obtains dissolves residue is 48ppm, and the fluidity of curcumin is 2.5s / g, and bulk density is 0.32g / ml, and curcumin content is 90.3%.

Embodiment 2

[0046] Dissolving: get 200 g of turmeric extract raw material with solvent residue of 1% (mass fraction), add 400 ml of propylene glycol, heat up to 150° C., stir and dissolve;

[0047] Reflux: Inject carbon dioxide at 150°C and start to cool down after heating for 1 hour;

[0048] Cooling and crystallization: the refluxed solution is cooled and stirred for crystallization, the stirring speed is 50r / min, and the temperature is lowered to 30°C and then kept for 24h;

[0049] Separation and drying: After the crystallized feed liquid is suction-filtered, the curcumin crystal semi-finished product is obtained, and the curcumin crystal semi-finished product is dried to obtain high-quality curcumin.

[0050] Through the production method of above-mentioned high-quality curcumin, the curcumin residue that obtains is 42ppm, and the fluidity of curcumin is 2.0s / g, and bulk density is 0.37g / ml, and curcumin content is 93.7%.

Embodiment 3

[0052] Dissolution: Take 150g of the turmeric extract raw material with a solvent residue of 5000ppm, add 1500ml of ethanol, heat up to 78°C, and stir to dissolve;

[0053] Reflux: Introduce nitrogen gas at 75°C, and start to cool down after reflux for 2 hours;

[0054] Cooling and crystallization: the refluxed solution is cooled and stirred for crystallization, the stirring speed is 30r / min, and the temperature is lowered to 20°C and then kept for 12h;

[0055] Separation and drying: After the crystallized feed liquid is suction-filtered, the curcumin crystal semi-finished product is obtained, and the curcumin crystal semi-finished product is dried to obtain high-quality curcumin.

[0056] Through the production method of above-mentioned high-quality curcumin, the curcumin residue that obtains is 30ppm, and the fluidity of curcumin is 1.5s / g, and bulk density is 0.45g / ml, and curcumin content is 95.6%.

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Abstract

The invention provides a high-quality curcumin product as well as a production method and application thereof. The high-quality curcumin product is low in solvent residue, good in fluidity and high instacking density. The method for producing the curcumin product comprises the following steps that a certain proportion of a crystallizing agent is added by taking a curcuma extract as a raw material, heating or reflux and cooling crystallization continues after dissolving at high temperature, a curcumin crude product is obtained after centrifuging or filtering, and the high-quality curcumin is obtained after further drying. The high-quality curcumin can be used as an additive for foods, medicines, feeds, cosmetics and the like.

Description

technical field [0001] The present invention relates to a kind of high-quality curcumin product, its production method and its application, especially a kind of low solvent residual, good fluidity, high-quality curcumin with high bulk density and its preparation method and the product in food, feed, Applications in the field of pharmaceutical products and cosmetics. Background technique [0002] Turmeric (Curcuma longa L.) belongs to the genus Curcuma longa. It is often used as a seasoning and dye. It is the dry rhizome of Curcuma longa L., a plant of the ginger family Curcuma. It grows from India to Australia, south to East Asia, and north to southern Zhejiang. It is used in Asia It has a history of thousands of years. The active ingredients that can be extracted from turmeric are curcumin (3.5% to 5%) and turmeric oil (about 5%). After more than 30 years of research, it has been found that curcumin has a variety of biological activities, such as anti-tumor, anti-virus, I...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/105A23L5/43A23K20/111C07C45/78C07C49/255A61K8/35A61Q19/00
CPCA23L33/105A23L5/43A23K20/111C07C45/78A61K8/35A61Q19/00A23V2002/00A23V2250/2112A23V2200/044C07C49/255A23K20/179A23K50/75C07C45/81C07C45/80A61Q1/02A61K8/9789A23L27/11A23L27/14C07C49/84
Inventor 齐立军彭静维高伟连运河常中强
Owner CHENGUANG BIOTECH GRP CO LTD
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