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Preparation process of alpha-amyrin fine particle

A technology of balsamic resin and fine particles, which is applied in the technical field of preparing α- balsamic resin fine particles by supercritical fluid crystallization technology, can solve the problems of side effects and organic solvent residues, reduce toxic and side effects, improve anti-fatigue, The effect of improving solubility

Inactive Publication Date: 2011-06-15
CHINA NAT ACAD NANOTECH & ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the particle size distribution obtained by the first two methods is often wide, which is difficult to meet the requirements of today's high-tech; although the solution method can obtain a narrow particle size distribution, the organic solvent used often remains in the particle and is cause unwanted side effects

Method used

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  • Preparation process of alpha-amyrin fine particle
  • Preparation process of alpha-amyrin fine particle
  • Preparation process of alpha-amyrin fine particle

Examples

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Effect test

Embodiment 1

[0033] Embodiment 1: a kind of preparation technology of α-amyresin alcohol fine particle, use existing supercritical fluid anti-solvent equipment, it is characterized in that it is made of following steps:

[0034] (1) Configure α-amyresin liquid: control the system pressure of the equipment to 12Mpa, the melting temperature to 45°C, the spray distance to 10cm, and the nozzle temperature to 45°C. After the indicators are stable, inject 60ml of α-amyresinol solution with a flow rate of 1ml / min;

[0035] Dissolve the 0.5% α-amyl alcohol solution 1 in ethanol, and input it into the equipment system through the high performance liquid chromatography solution pump 2; the dissolution temperature is 40°C, and the equipment system pressure is 12MPa;

[0036] Entrainer 10-1 is absolute ethanol, and the flow rate is 20ml / min;

[0037] (2) Carbon dioxide feed: the CO in the steel cylinder 2 9 Enter the supercritical fluid anti-solvent equipment system into the crystallization kettle...

Embodiment 2

[0041] Embodiment 2: a kind of preparation technology of α-amyresin alcohol fine particle, use existing supercritical fluid anti-solvent equipment, it is characterized in that it is made of following steps:

[0042] (1) Configure α-amyresin liquid: control the system pressure of the equipment to 12Mpa, the melting temperature to 45°C, the spray distance to 10cm, and the nozzle temperature to 45°C. After the indicators are stable, inject 60ml of α-amyresinol solution with a flow rate of 1ml / min;

[0043] Concentration is that 0.5% α-amyresin alcohol solution 1 is dissolved in ethanol, and its proportioning is ethanol: α-amyresin alcohol=100:2; In the equipment system by high performance liquid chromatography solution pump 2 input; Dissolving temperature The temperature is 40℃, and the equipment system pressure is 12MPa;

[0044] Entrainer 10-1 is acetone, and the flow rate is 1.5ml / min;

[0045] (2) Carbon dioxide feed: the CO in the steel cylinder 2 Enter the supercritical...

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Abstract

The invention relates to a preparation process of an alpha-amyrin fine particle, which uses the traditional supercritical fluid anti-solvent equipment. The preparation process of the alpha-amyrin fine particle comprises the following steps of: (1) preparing alpha-amyrin liquid; (2) feeding carbon dioxide; (3) crystallizing and separating out alpha-amyrin; and (4) detecting. The preparation process is suitable for alpha-amyrin raw materials, can prepare the ultrafine particles which are beneficial to the absorption of a human body and can enhance the solubility and the curative effect of the alpha-amyrin and reduce the use cost and the toxic side effect; and in addition, the alpha-amyrin ultrafine particle prepared by the process has unique clinical advantages.

Description

(1) Technical field: [0001] The invention relates to a preparation process of α-amyresinol fine particles, in particular to a process for preparing α-amyresinol fine particles by applying supercritical fluid crystallization technology. (two) background technology: [0002] As far as drugs are concerned, the size of particles can directly affect the degree of absorption and efficacy of drugs. Generally speaking, the smaller the drug particle, the larger the specific surface area, the easier it is to dissolve in the body fluid of the human body, and it can be completely absorbed by the human body, thus playing a good curative effect. Slow, it is difficult to be fully absorbed and utilized to achieve the desired drug effect. [0003] In the prior art, the refinement of drug particles is usually achieved by crushing method, ball milling method, solution method and supercritical fluid crystallization technology. However, the particle size distribution obtained by the first two ...

Claims

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Application Information

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IPC IPC(8): A61P17/02A61P31/06A61P31/08A61K31/56
Inventor 魏海赵永亮郑洪浩
Owner CHINA NAT ACAD NANOTECH & ENG
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