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Application of light controlled neutrophilic granulocytes in medicines for treating cancers

A technology of neutrophils and light regulation, applied in the fields of application, animal cells, and drug combinations, can solve the problems of inability to change the immunosuppressive microenvironment of solid tumors and limited curative effect, so as to improve the phenomenon of immunosuppression and improve the therapeutic effect. effect of effect

Inactive Publication Date: 2020-02-07
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In view of the above-mentioned deficiencies in the prior art, the purpose of the present invention is to provide an application of light-regulated neutrophils in drugs for the treatment of cancer, aiming to solve the problem that existing drugs cannot change the immunosuppressive microenvironment of solid tumors and cause curative effect restricted question

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  • Application of light controlled neutrophilic granulocytes in medicines for treating cancers
  • Application of light controlled neutrophilic granulocytes in medicines for treating cancers
  • Application of light controlled neutrophilic granulocytes in medicines for treating cancers

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Embodiment Construction

[0037] The present invention provides an application of light-regulated neutrophils in a drug for treating cancer. In order to make the purpose, technical scheme and effect of the present invention clearer and clearer, the present invention will be further described in detail below. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0038] An embodiment of the present invention provides an application of light-regulated neutrophils in drugs for treating cancer, wherein the light-regulated neutrophils express cells for recruiting and expanding immune cells under light conditions factor.

[0039] In this example, compared with T cells that account for less in the body, neutrophils, as the largest group of white blood cells (50-70%) in the human body, can migrate to the infection site at the first time when inflammation occurs. It is highly mobile and can enter inflammatory ti...

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Abstract

The invention discloses application of light controlled neutrophilic granulocytes in medicines for treating cancers. The light controlled neutrophilic granulocytes can express cytokines for recruitingand amplifying immune cells under a light condition. The performance that neutrophilic granulocytes can be recruited by tumors is utilized, a light controlled cytokine system is expressed in the neutrophilic granulocytes and is used for in-vitro verifying that levels of different cytokines released by modified cells and promoting and inhibiting effects of the cytokines on tumor cells can be detected under different times and strengths of light control. Therefore, cytokine releasing and other immune cell recruiting around the tumor cells can be realized in a human-controlled manner, growth andproliferation of tumor cells can be influenced, and the aim of changing the growing microenvironment of the tumor cells can be achieved finally.

Description

technical field [0001] The invention relates to the field of cancer treatment medicines, in particular to the application of light-regulated neutrophils in medicines for treating cancer. Background technique [0002] As we all know, malignant tumors have become the leading cause of death in the world. According to statistics, about 8.8 million people died of cancer in 2015. The main causes of death include lung cancer, liver cancer, colon cancer, gastric cancer and breast cancer. There is a trend of rejuvenation. Traditional chemotherapy, radiotherapy and other methods cannot significantly improve the survival rate of cancer patients, especially for advanced patients. The emerging T cell chimeric antigen receptor (CAR-T) therapy, although in malignant B cell tumors, acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), non-Hodgkin's lymphoma (NHL), etc. Significant progress has been made in blood-related malignancies, but there are still many problems: su...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/15A61P35/00C12N15/867C12N5/10
CPCA61K35/15A61P35/00C12N5/0642C12N15/86C12N2740/15043C12N2510/00Y02A50/30
Inventor 汪会荣黄巍叶德全
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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