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Modified liposome and composition, and preparation methods and applications of modified liposome and composition

A liposome composition and liposome technology, applied in the directions of botanical equipment and method, application, animal repellent, etc., can solve the problem of unfavorable medicinal liquid deposition, poor conduction effect, poor vesicle stability, etc. problems, to achieve good conduction effect, excellent field control effect, and good vesicle stability.

Active Publication Date: 2020-02-04
YANGZHOU SPED CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the problem of poor conduction effect on the target of pesticide adjuvants in the prior art, poor vesicle stability, and unfavorable deposition of medicinal liquid on the target, the present invention utilizes glycerophospholipids, sterols, polyols and cyclic Oxygen compounds are used as raw materials to synthesize modified liposomes, and the modified liposomes are used to prepare a kind of liquid that is easy to disperse in water, has good vesicle stability, is easy to biodegrade, and has stable properties. It has good conduction effect on the target and can benefit the medicinal liquid Deposit on the target, an adjuvant that can be widely used in the field of pesticides

Method used

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  • Modified liposome and composition, and preparation methods and applications of modified liposome and composition
  • Modified liposome and composition, and preparation methods and applications of modified liposome and composition
  • Modified liposome and composition, and preparation methods and applications of modified liposome and composition

Examples

Experimental program
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Effect test

Embodiment 1

[0038] The preparation method of the modified liposome in the present embodiment, comprises the following steps:

[0039] 835g soybean oil containing 10% phospholipids, 130g cholesterol, 25g glycerol, 10g diethanolamine, 6.78g KOH (catalyst) were put into an alkoxylation reactor, and the nitrogen was replaced three times. Raise the temperature to 95-105°C for dehydration for 1 hour, then control the temperature to 120-150°C, feed 1261g of ethylene oxide (EO), control the feed temperature at 100-150°C, and the maximum feed pressure is less than 0.4MPa; the feed is completed . Curing at 120-150°C, when the curing pressure is close to 0.02MPa, nitrogen gas is introduced to keep the pressure at 0.15-0.25MPa. When the pressure in the reactor remains constant, the reaction ends; the aging time is about 1-2 hours. At 120-135°C, vacuumize for 0.5-1h, cool down to 70-80°C, add neutralizing reagent HAc to adjust the pH to 5-7. After the reaction is finished, the modified liposome pro...

Embodiment 2

[0045] Put 835g soybean oil containing 30% phospholipids, 130g cholesterol, 25g glycerol, 10g diethanolamine, and 6.78g KOH into an alkoxylation reaction kettle, and replace nitrogen three times. Raise the temperature to 95-105°C for dehydration for 1 hour, then control the temperature to 120-150°C, feed 1261g of EO, control the feed temperature at 100-150°C, and the maximum pressure of the feed is less than 0.4MPa; the feed is complete. Curing at 120-150°C, when the curing pressure is close to 0.02MPa, nitrogen gas is introduced to keep the pressure at 0.15-0.25MPa. When the pressure in the reactor remains constant, the reaction ends; the aging time is about 1-2 hours. At 120-135°C, vacuumize for 0.5-1h, lower the temperature to 70-80°C, add neutralizing reagent phosphoric acid to adjust the pH to 5-7. After the reaction is finished, the modified liposome product is obtained, and the sample is recorded as example 2.

[0046] Weigh 89.2g of the sample of Example 2, together ...

Embodiment 3

[0048] Put 835g soybean oil containing 50% phospholipids, 130g cholesterol, 25g glycerol, 10g diethanolamine, and 6.78g KOH into an alkoxylation reaction kettle, and replace nitrogen three times. Raise the temperature to 95-105°C for dehydration for 1 hour, then control the temperature at 120-150°C, feed 1261g of EO, control the feed temperature at 100-150°C, and the maximum pressure of the feed is less than 0.4MPa; the feed is complete. Curing at 120-150°C, when the curing pressure is close to 0.02MPa, nitrogen gas is introduced to keep the pressure at 0.15-0.25MPa. When the pressure in the reactor remains constant, the reaction ends; the aging time is about 1-2 hours. At 120-135°C, vacuumize for 0.5-1h, lower the temperature to 70-80°C, add neutralizing reagent phosphoric acid to adjust the pH to 5-7. After the reaction is finished, the modified liposome product is obtained, and the sample is recorded as example 3.

[0049] Weigh 89.2 g of the sample of Example 3, together...

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Abstract

The invention belongs to the field of pesticide aids, and provides a modified liposome and a composition, and preparation methods and applications of the modified liposome and the composition. The preparation method of the modified liposome comprises: adding a mixture of glycerophospholipid, sterol and a polyhydroxy compound into a reaction kettle as an initiator under the action of a catalyst, carrying out heating dehydration, introducing ethylene oxide, and carrying out ring-opening polymerization, aging and neutralization to prepare the product, wherein the polyhydroxy compound is a composition of alcohol and alcohol amine. The invention further provides a liposome composition prepared from the modified liposome, wherein the liposome composition as a pesticide aid has advantages of easydispersion in water, good vesicle stability, easy biodegradation, stable properties, good conduction effect on targets and easy deposition of pesticide liquids on targets, and can be widely used in the field of pesticides.

Description

technical field [0001] The invention relates to the field of pesticide adjuvants, in particular to a modified liposome and its composition, preparation method and application. Background technique [0002] Liposomes are spherical bodies formed by dispersing phospholipids and additives in water. It is both hydrophilic and hydrophobic, and can wrap both water-soluble drugs and fat-soluble drugs. Water-soluble drugs are encapsulated in the water layer structure of liposomes, while fat-soluble or amphipathic drugs are encapsulated in lipophilic part of liposomes or lipid bilayers. Liposomes are similar to cell structures and have the characteristics and functions of biological membranes, so they are also called artificial biological membranes. The liposome dosage form has the characteristics of targeting, sustained release, low toxicity, low residue, non-toxic to organisms, and no side effects. [0003] At present, liposome research has been widely carried out in various phar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N25/08A01N25/10A01N25/30
CPCA01N25/08A01N25/10A01N25/30
Inventor 王磊宋文勇曹雄飞秦敦忠陈世国
Owner YANGZHOU SPED CHEM
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