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A kind of eye aminopeptide injection and its preparation method and application

An eye aminopeptide and injection technology, which is applied in the field of eye aminopeptide injection and its preparation, can solve the problems of large investment, many process steps, and low content of eye aminopeptide.

Active Publication Date: 2021-09-21
HUBEI WEISHI BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For the extraction process of eye aminopeptide, the existing technology mostly adopts alcohol extraction, activated carbon adsorption, decolorization and other steps to obtain it. There are many process steps and large investment, and the content of eye aminopeptide in the extracted product is low

Method used

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  • A kind of eye aminopeptide injection and its preparation method and application
  • A kind of eye aminopeptide injection and its preparation method and application
  • A kind of eye aminopeptide injection and its preparation method and application

Examples

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Effect test

preparation example Construction

[0017] I. Preparation of Eye Injection

[0018] The present invention provides a method of preparing an eye amino peptide injection, comprising the step of preparing pork eyeballs through extract, adsorption, refining, and post treatment.

[0019] In addition: Take pig eyeball, then add ethanol solution, extract, extract, to obtain the first filtrate and first residue; the first filter residue is subjected to a ethanol solution to extract, to obtain a second filtrate and second Residual residue; the second filter residue is then extracted again, and the third filtrate and the third residue, the first filtrate, the second filtrate, and the third filtrate are combined to obtain the mercury liquid; extract the pork eye ball through two ethanol The solution extraction and the purified water are lifted, and the eye ammonide in the pork eyeball can be repeatedly extracted. To meet this requirement, the mass ratio of pig eyeballs and ethanol solution is 1: 100-400, wherein the ethanol so...

Embodiment 1

[0031] Example 1: 300 of the epithano peptide of Example 1, 400 calcined ointment, 10 vitamins, 100 pieces of mysterious powder, 30 pieces of fridge, 3000 parts of Astragal, and 3,000 water, the agent is a suspension.

Embodiment 2

[0032] Example 2: 100 parts of Eye, 600 calcined ointments, 20 vitamins, 800 mysterious powder, 20 bib pieces, 3000 parts of Astragal, and 3,000 water, the agent is a suspension.

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Abstract

The invention discloses an ophthalmic aminopeptide injection, a preparation method and application thereof. The preparation method comprises the following steps: taking pig eyeballs, smashing them, extracting them twice with ethanol solution and once with purified water, filtering after extraction, merging the filtrates to obtain a combined liquid; concentrating the combined liquid, heating to boiling, filtering, adding the filtrate After activated carbon adsorption treatment and titanium rod filter treatment, the filtrate is cooled to obtain a cooling liquid; the permeate is collected after the cooling liquid is treated by ultrafiltration, and affinity chromatography is performed to collect the eluent of the target component; the eluent is concentrated Afterwards, the ophthalmic aminopeptide injection is obtained through preparation, potting and sterilization. It is also said that the eye aminopeptide injection is formulated to obtain a composition medicament for treating recurrent aphthous ulcers. In the present invention, by controlling the process parameters of the preparation method, the peptide content in the prepared eye aminopeptide injection is as high as 79.2%. After the curative effect test of recurrent aphthous ulcers, it is shown that the composition medicament prepared by the eye aminopeptide injection has the ability to treat recurrent Medicinal effects for aphthous ulcers.

Description

Technical field [0001] The present invention relates to the field of composition pharmaceutical techniques, in particular, an eye amino peptide injection and a preparation method thereof. Background technique [0002] Recurrent acne is a common disease in the oral mucosal lesions generated by multiple factors, causing factors such as ordinary colds, indigestion, nervousness, depression, and other factors, and has certain recurrence. Generally, the main symptoms are skeptoplasses, exhibiting self-restricted rows, 10 days, self-healing, specific mechanisms are unclear. There is currently a lack of effective treatment. The pathogenic factors may also be associated with alpha-hemolytic L-S. streptococci, digestive system disease, mental factors, endocrine disorders, iron deficiency, zinc, folic acid, vitamins. [0003] Eye is an amino acid, polypeptide, nucleotide, and trace element extracted from pork eyeball or bark eye, and has a metabolism that promotes eye tissue, scar healing, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K14/78A61K35/30A61K9/10A61P1/02A61K36/481A61K31/045A61K31/07A61K31/714A61K33/04A61K33/06
CPCA61K9/0019A61K9/10A61K31/045A61K31/07A61K31/714A61K33/04A61K33/06A61K35/30A61K36/481A61P1/02A61K2300/00
Inventor 罗先隽
Owner HUBEI WEISHI BIO PHARMA
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