Hydrophobic silicon quantum dot capable of being subjected to surface chemical modification, and preparation method and application thereof

A technology of silicon quantum dots and surface chemistry, applied in the field of hydrophobic silicon quantum dots and its preparation, can solve the problems of single surface modification of silicon quantum dots, limited application value, and difficulty in multiple modifications, and achieve good anti-tumor activity , easy to separate, enhance the effect of applicability

Active Publication Date: 2019-12-20
湖南长星生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the surface of traditional silicon quantum dots has a single modifiability, and it is difficult to effectively perform multiple modifications at the same time, which limits its application value.

Method used

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  • Hydrophobic silicon quantum dot capable of being subjected to surface chemical modification, and preparation method and application thereof
  • Hydrophobic silicon quantum dot capable of being subjected to surface chemical modification, and preparation method and application thereof
  • Hydrophobic silicon quantum dot capable of being subjected to surface chemical modification, and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0036] A kind of hydrophobic silicon quantum dot that can be surface chemically modified of the present invention, its preparation method is as follows:

[0037] Weigh 0.0120g of tannin and dissolve it in 3mL of ultrapure water, stir to dissolve, add 0.5mL of (3-aminopropyl)trimethoxysilane solution (0.6g), and react in a water bath at 40°C for 24h; the reaction is complete, 9 mL of absolute ethanol was added, and 1.5 mL of octadecyltrimethoxysilane (1.6 g) was added during stirring to react until a precipitate was precipitated, and centrifuged, and the obtained precipitate was the hydrophobic silicon quantum dot of the present invention.

[0038] The transmission electron microscope picture of the silicon quantum dot that present embodiment obtains is as figure 1 As shown, its particle size is around 4nm.

[0039] The XPS figure of the silicon quantum dot that present embodiment obtains is as follows figure 2 As shown, the results show that the surface of silicon quantum d...

Embodiment 2

[0046] A kind of hydrophobic silicon quantum dot that can be surface chemically modified of the present invention, its preparation method is as follows:

[0047] Weigh 0.0120g of tannin and dissolve it in 3mL of ultrapure water, stir to dissolve, add 0.5mL of (3-aminopropyl)trimethoxysilane solution (0.6g), and react in a water bath at 70°C for 4h; the reaction is complete, 9 mL of absolute ethanol was added, and 1.5 mL of octadecyltrimethoxysilane (1.6 g) was added while stirring to react until a precipitate was precipitated, and centrifuged, and the obtained precipitate was the hydrophobic silicon quantum dot of the present invention.

[0048] The surface of the silicon quantum dots prepared in this example is rich in hydroxyl and amino groups, with high purity, good water solubility, and good stability. Its surface can be chemically modified at the same time, and can be complexed with various metal ions. It is non-destructive and will not deteriorate when placed at room tem...

Embodiment 3

[0050] A kind of application of the hydrophobic silicon quantum dot of the present invention in the field of biological imaging, the method is as follows:

[0051] Weigh 200 mg of the hydrophobic silicon quantum dots obtained in Example 1 and dissolve them in 4 mL of chloroform, stir to dissolve, add 2 mg of FAM-NHS, 2 μL of triethylamine, and react at room temperature for 24 hours; It is a hydrophobic quantum dot modified with FAM. After purification and drying, weigh 1 mg of the quantum dots and 2 mg of DSPC-PEG to prepare micelles, and perform intracellular imaging in MCF-7 cells.

[0052] Intracellular imaging of FAM-modified hydrophobic silicon quantum dots Figure 7 shown by Figure 7 It can be seen that the micelles prepared by the hydrophobic silicon quantum dots can be used for intracellular imaging.

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Abstract

The invention discloses a hydrophobic silicon quantum dot capable of being subjected to surface chemical modification. The surface of the hydrophobic silicon quantum dot contains hydroxyl and amino. The preparation method of the hydrophobic silicon quantum dot comprises the following steps: dissolving a silicon source and tannic acid in ultrapure water, carrying out stirring for reaction, adding absolute ethyl alcohol into the obtained silicon quantum dot solution, adding octadecyl trimethoxy silane for reaction, separating out solid, carrying out filtering, and carrying out washing and dryingto obtain the hydrophobic silicon quantum dot. The prepared silicon quantum dot is high in purity, good in water solubility and good in stability, the surface of the silicon quantum dot can be subjected to various chemical modifications at a same time, can be complexed with various metal ions, has hydrophobicity, cannot deteriorate after long-term placement at room temperature, and has good anti-tumor activity. The preparation method has the advantages of low temperature requirement, easy control, high reaction efficiency, simple preparation, easily available raw materials, low cost and easyrealization of industrial production. The invention also discloses an application of the hydrophobic silicon quantum dot in the fields of biological imaging and anti-cancer drug preparation.

Description

technical field [0001] The invention belongs to the technical field of nanometer materials, and in particular relates to a hydrophobic silicon quantum dot capable of surface chemical modification and a preparation method and application thereof. Background technique [0002] Silicon quantum dots are silicon nanomaterials with good application prospects, which have the characteristics of good water solubility, high fluorescence intensity, stable optical properties, and easy functionalization. Silicon quantum dots have low cytotoxicity and good biocompatibility, and surface modification of silicon quantum dots can further enhance their applications in medical fields such as drug loading and bioimaging. However, the surface of traditional silicon quantum dots has a single modifiability, and it is difficult to effectively perform multiple modifications at the same time, which limits its application value. Therefore, there is an urgent need to find a silicon quantum dot whose su...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/02C09K11/59C09K11/06B82Y20/00B82Y30/00B82Y40/00G01N21/64A61K49/00A61K41/00A61K47/52A61K31/704A61P35/00
CPCA61K31/704A61K41/0071A61K47/52A61K49/0067A61P35/00B82Y20/00B82Y30/00B82Y40/00C09K11/025C09K11/06C09K11/59G01N21/6428G01N2021/6439
Inventor 王珊胡欣王颖江仁庭贾国萍竺敏宋雨茜胡敦
Owner 湖南长星生物医药有限公司
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