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Medicine for resisting acute gouty arthritis and preparation method and application thereof

A technology for acute gout and arthritis, applied in the field of drug preparation, to meet the needs of therapeutic applications

Inactive Publication Date: 2019-12-20
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, among the existing drugs, there is still no report on the treatment of acute gouty arthritis

Method used

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  • Medicine for resisting acute gouty arthritis and preparation method and application thereof
  • Medicine for resisting acute gouty arthritis and preparation method and application thereof
  • Medicine for resisting acute gouty arthritis and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The first embodiment of the present invention proposes a preparation method of the total extract of Rabbit's ear grass, which specifically includes the following steps:

[0040] (1) Take 117g of the dry medicinal material of Rabbit's Ear Grass and grind it, heat and reflux extraction with 75% ethanol with a weight ratio of 10 times for 3 times, each time for 2 hours, combine and concentrate under reduced pressure to obtain the short panicle Rabbit Ear Herb Total Extract.

Embodiment 2

[0042] The preparation method of the extract from the polar parts of Larvae brevista which is proposed in the second embodiment of the present invention specifically includes the following steps:

[0043] (1) Take 4.7kg of dry medicinal materials of Rabbit ear grass and grind them, heat and reflux extraction with 75% ethanol with a weight ratio of 10 times for 3 times, each time for 2 hours, combine the filtrate and concentrate under reduced pressure to obtain short Rabbit ear grass total extract extract;

[0044] (2) After adding the total extract of Brachycarpus brevifolia into water with a weight ratio of 0.5 times to dissolve, it is adsorbed by macroporous adsorption resin column D101 chromatography, followed by distilled water, 30% ethanol, and 50% ethanol , 95% ethanol for gradient elution, collect the eluate, concentrate and dry under reduced pressure to obtain the extracts of Brachycarpus brevifolia at different polar parts.

[0045] It should be noted here that, in t...

Embodiment 3

[0047] In this example, the total extract of Rabbit ear grass prepared in the above example 1 was subjected to a pharmacodynamic experiment for anti-acute gouty arthritis, and the specific experimental method is as follows:

[0048] Experimental method: 60 SD rats, male, were randomly and evenly divided into 6 groups (n=10 represents 10 rats in each group), and divided into normal group (rats were injected with 0.1ml of sodium chloride solution at the right rear ankle joint) +10ml·kg -1 gavage with distilled water), model group (inject 0.1ml of 50mg.ml -1 Sodium urate solution+10ml·kg -1 gavage with distilled water), positive drug group (injection of 0.1ml of 50mg.ml -1 Sodium urate solution+0.3 mg·kg -1 colchicine gavage), low-dose group of Rabbit ear grass (inject 0.1ml of 50mg.ml -1 Sodium urate solution + 0.8g kg -1 The total extract of Rabbit's Ear Grass for short-spike) and the middle-dose group of Rabbit's-ear Grass for rats (inject 0.1ml of 50mg.ml -1 Sodium urat...

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Abstract

The invention relates to a medicine for resisting acute gouty arthritis and a preparation method and application thereof. The effective components of the medicine are a lagotis brachystachya total extract extractum and a lagotis brachystachya polar part extractum, wherein the medicine is dried whole herb of a scrophulariaceae plant Lagotid brachystachya Maxim. The preparation process of the lagotis brachystachya polar part extractum comprises the following steps: carrying out ethanol heating reflux extraction on lagotis brachystachya herb, and carrying out vacuum concentration to obtain the lagotis brachystachya total extract extractum; and adsorbing the lagotis brachystachya total extract extractum through macroporous adsorption resin column D101 chromatography, then carrying out gradientelution with distilled water and ethanol with different volume fractions, performing collecting to obtain corresponding eluent, and carrying out reduced-pressure recovery to obtain the lagotis brachystachya polar part lagotis brachystachya. The medicine for resisting acute gouty arthritis provided by the invention can well treat gouty arthritis and has a wide application prospect.

Description

technical field [0001] The invention relates to the technical field of medicine preparation, in particular to a medicine with anti-acute gouty arthritis, a preparation method and application thereof. Background technique [0002] Tibetan medicine, as an ethnic medicine second only to traditional Chinese medicine in Chinese medicine, has a long history and is an important part of traditional medicine. The theoretical system of Tibetan medicine is complete and sound, the source of medicine is pure and its curative effect is remarkable, and it has exerted its own unique advantages on the basis of combining modern medicine. [0003] Gouty arthritis is an extremely common disease. Specifically, acute gouty arthritis is an inflammation caused by increased purine metabolism in the body, excessive production of uric acid or poor excretion of uric acid in the blood, and deposition of urate crystals in the synovium, joint capsule or other tissues. disease. The clinical manifestat...

Claims

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Application Information

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IPC IPC(8): A61K36/80A61P19/02A61P19/06A61P29/00
CPCA61K36/80A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55A61P19/02A61P19/06A61P29/00
Inventor 朱继孝单佳铃程虹毓李敏钟国跃
Owner JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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