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Application of andrographolide in preparation of accelerator for promoting reverse cholesterol transport

A technology of cholesterol reverse transport and andrographolide, applied in application, cardiovascular system diseases, function of food ingredients, etc., can solve the problems of increasing high-density lipoprotein cholesterol, lowering and other problems, and achieve the effect of promoting reverse transport

Inactive Publication Date: 2019-12-06
GUANGANMEN HOSPITAL CHINA ACAD OF CHINESE MEDICAL SCI
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a new application of andrographolide for the technical problems of existing cardiovascular diseases such as hyperlipidemia and accumulation of cholesterol in cells, leading to atherosclerotic lesions. Promoter of transport, anti-atherosclerotic cholesterol reverse transport enhancer, anti-atherosclerotic drugs, drugs for the treatment of hyperlipidemia, new applications in drugs for the treatment of cardiovascular diseases, andrographolide for anti-atherosclerosis Reduce intracellular cholesterol content, reverse the intracellular cholesterol transport to the outside of the cell, inhibit the accumulation of cholesterol between smooth muscle cell collagen and elastic fibers, avoid smooth muscle cell proliferation, regulate blood lipids, and reduce serum cholesterol and triglycerides and low-density lipoprotein cholesterol, while having the effect of raising high-density lipoprotein cholesterol

Method used

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  • Application of andrographolide in preparation of accelerator for promoting reverse cholesterol transport
  • Application of andrographolide in preparation of accelerator for promoting reverse cholesterol transport
  • Application of andrographolide in preparation of accelerator for promoting reverse cholesterol transport

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Experimental program
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Effect test

Embodiment 1

[0079] Embodiment 1 prepares andrographolide

[0080] After the medicinal material Andrographis paniculata (1kg) is crushed into coarse powder, add ethanol solution (mass concentration is 75%, usually 50-95%), heat and reflux extraction, the number of times of extraction is 2 times (usually 2-3 times), each time The volume of the ethanol solution during extraction is 8L (usually 8-12L), that is, the volume of the ethanol solution is 8-12 times of that of Andrographis paniculata medicinal material during each extraction.

[0081] The extract is concentrated under reduced pressure until it has no alcohol smell, and the extract-concentrate is obtained. The temperature of the concentration under reduced pressure is 70°C, and the relative vacuum is -0.09~-0.075MPa. The weight of the extract-concentrate and the raw material The weight ratio of Andrographis paniculata is 1:1 (usually 1-5:1).

[0082] Add activated carbon to the extract-concentrate, stir, filter after decolorization ...

Embodiment 3

[0124] Embodiment 3, the effect of andrographolide on APOE mice

[0125] 1. Experimental materials

[0126] Sixty 8-week-old male APOE (- / -) mice and 10 wild-type (wide type, WT) C57BL / 6J mice, weighing 22±2g, were purchased from Beijing Weitong Lihua Company.

[0127] Medicine is identical with embodiment 2.

[0128] 2. Grouping and intervention methods

[0129] All mice were randomly grouped according to body weight after adaptive feeding for 1 week, and the groups were as follows:

[0130] Normal control group (C57 group): 10 C57BL / 6J mice were given normal diet + normal saline.

[0131] Model control group (Model group): 10 APOE (- / -) mice fed with high cholesterol diet + normal saline.

[0132] Positive control group (ATOR group, Atorvastatin group): 10 APOE (- / -) mice fed with high cholesterol diet + atorvastatin calcium (10 mg / kg / d) orally.

[0133] Andrographolide high-dose group (B high group): 10 APOE (- / -) mice were given a high-cholesterol diet + andrographoli...

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Abstract

The invention discloses an application of andrographolide in preparation of an accelerator for promoting reverse cholesterol transport and an application of the andrographolide in medicament for resisting atherosclerosis. Experiments prove that andrographolide has significant effects of promoting intracellular reverse cholesterol transport and resisting atherosclerosis, is significant in curativeeffect, fast in effectiveness, low in toxic and side effects, especially free of influence on liver and kidney functions by andrographolide, is a safe, efficient and stable medicine or health care product for treating and conditioning cardiovascular diseases, is suitable for industrial production and is easy to popularize. Therefore, a new field is developed for application of andrographolide, anda novel drug source is provided for promoting intracellular reverse cholesterol transport, reducing intracellular cholesterol content, preventing and treating atherosclerosis and cardiovascular diseases.

Description

technical field [0001] The invention relates to a compound capable of regulating blood lipids and preventing the development of atherosclerotic heart disease, a preparation method and application thereof, in particular to an anti-atherosclerosis cholesterol reverse transport accelerator, a preparation method and its application. application. Background technique [0002] Cardiovascular disease (CVD), including unstable angina, stroke, acute myocardial infarction with or without ST-segment elevation, and sudden coronary death, is the leading cause of cardiovascular morbidity and mortality worldwide. Most cardiac deaths are due to coronary atherosclerotic heart disease. In my country's Beijing area, the average annual growth rate of the incidence of acute coronary heart disease events from 1984 to 1993 was 2.3%. Nationally, the average annual growth rate of the incidence of acute coronary events from 1984 to 1997 was 1.7%. [0003] Coronary heart disease, also known as coro...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P3/06A61P9/10C07D307/60A23L33/105
CPCA61K31/365A61P3/06A61P9/10C07D307/60A23L33/105A23V2002/00A23V2200/326A23V2200/3262A23V2250/21
Inventor 胡元会崔翰明师帅张秋燕宋庆桥吴华芹魏艺耿彦婷蒋雨辰
Owner GUANGANMEN HOSPITAL CHINA ACAD OF CHINESE MEDICAL SCI
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