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Method for preparing starch-beta-cyclodextrin microspheres based on reversed-phase latex method

The technology of cyclodextrin and latex method is applied in the field of preparing starch-β-cyclodextrin microspheres based on inverse latex method, which can solve the problems of low degree of cross-linking reaction, poor microsphere yield and slow release performance of microspheres, etc. To achieve the effect of improving the flow effect, optimizing the slow release effect, and moisturizing the internal structure

Active Publication Date: 2019-12-03
CHENGDU TECHCAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0004] In the preparation of existing starch-β-cyclodextrin microspheres, because the surface of the starch raw material is smooth and flat without any damage, the inner layer is an amorphous region and the outer layer is a crystalline region, and the degree of cross-linking reaction with β-cyclodextrin is relatively low. Therefore, the yield of the prepared microspheres and the sustained release performance of the microspheres are poor

Method used

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  • Method for preparing starch-beta-cyclodextrin microspheres based on reversed-phase latex method
  • Method for preparing starch-beta-cyclodextrin microspheres based on reversed-phase latex method

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Embodiment 1

[0030] A kind of method of preparing starch-β-cyclodextrin microspheres based on the inverse latex method of the present embodiment comprises the following steps:

[0031] Step 1, starch pretreatment: firstly disperse the starch evenly in the emollient solution and soak for 1 hour, then centrifuge and dry, then add 25U / g starch branching enzyme, then react at 55°C for 1 hour, finally wash with water, centrifuge and dry, can;

[0032] Step 2, preparation of the oil phase: first add Span-80 and preheat it in a water bath at 55°C for 10 minutes, then add Tween-80 and stir at a speed of 80r / min for 25 minutes, then add kerosene and continue stirring for 15 minutes;

[0033] Step 3, preparation of cross-linking aids: Add chloroacetic acid into a three-necked reaction flask, then add rare earth activation solution and disperse ultrasonically for 10 minutes, with ultrasonic power of 25W, and then at 60°C at a speed of 100r / min Stir for 35min;

[0034] Step 4, starch-β-cyclodextrin ...

Embodiment 2

[0043] A kind of method of preparing starch-β-cyclodextrin microspheres based on the inverse latex method of the present embodiment comprises the following steps:

[0044] Step 1. Starch pretreatment: Disperse the starch evenly in the softening solution and soak for 2 hours, then centrifuge and dry, then add 35U / g starch branching enzyme, then react at 65°C for 2 hours, and finally wash with water, centrifuge and dry. can;

[0045] Step 2, preparation of the oil phase: first add Span-80 and preheat it in a water bath at 65°C for 20 minutes, then add Tween-80 and stir at a speed of 100r / min for 25 minutes, then add kerosene and continue stirring for 25 minutes;

[0046] Step 3, preparation of cross-linking aids: Add chloroacetic acid into a three-necked reaction bottle, then add rare earth activation solution and disperse ultrasonically for 20 minutes, with ultrasonic power of 35W, and then at 60°C at a speed of 200r / min Stir for 35-45min;

[0047] Step 4, starch-β-cyclodextr...

Embodiment 3

[0056] A kind of method of preparing starch-β-cyclodextrin microspheres based on the inverse latex method of the present embodiment comprises the following steps:

[0057] Step 1, starch pretreatment: firstly disperse the starch evenly in the emollient solution and soak for 1.5h, then centrifuge and dry, then add 30U / g starch branching enzyme, then react at 60°C for 1.5h, finally wash with water, centrifuge, dry, you can;

[0058] Step 2, preparation of the oil phase: first add Span-80 and preheat it in a water bath at 60°C for 15 minutes, then add Tween-80 and stir at a speed of 90r / min for 25 minutes, then add kerosene and continue stirring for 20 minutes;

[0059] Step 3, preparation of cross-linking aids: Add chloroacetic acid into a three-necked reaction flask, then add rare earth activation solution and disperse ultrasonically for 15 minutes, with an ultrasonic power of 30W, and then at 60°C at a speed of 150r / min Stir for 40min;

[0060] Step 4, starch-β-cyclodextrin ...

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Abstract

The invention belongs to the technical field of preparation of starch-beta-cyclodextrin microspheres, and provides a method for preparing starch-beta-cyclodextrin microspheres based on reversed-phaselatex method. The preparation method comprises the following steps: step 1, starch pretreatment: firstly, uniformly dispersing starch into a softening and moistening solution for 1-2 hours of immersion, then centrifuging and drying, then adding 25-35U / g of starch branching enzyme, then reacting for 1-2 hours at 55-65 DEG C, and finally washing with water, centrifuging and drying, so as to obtain afinished product. According to the prepared novel jasmine essence sustained release agent-starch-beta-cyclodextrin microspheres prepared using the reversed-phase latex method, the starch and the beta-cyclodextrin are both taken as the main materials to prepare the sustained-release agent, and the advantages of the starch and the beta-cyclodextrin are achieved at the same time, adsorption sites onthe surface of the microspheres are increased, essence adsorption capacity is increased, and the sustained-release effect is optimized.

Description

technical field [0001] The invention relates to the technical field of preparation of starch-β-cyclodextrin microspheres, in particular to a method for preparing starch-β-cyclodextrin microspheres based on an inverse latex method. Background technique [0002] Microspheres refer to the microparticle dispersion system formed by dispersing or adsorbing drugs in macromolecules and polymer matrices. There are many carrier materials for preparing microspheres, which are mainly divided into natural polymer microspheres (such as starch microspheres, albumin microspheres, gelatin microspheres, chitosan, etc.) and synthetic polymer microspheres (such as polylactic acid microspheres). Microsphere starch is made of soluble starch, and cyclohexane and water constitute a reverse suspension system, and starch microspheres are synthesized by reverse suspension polymerization. The obtained starch microspheres were degraded in vitro by artificial intestinal juice, and the synthesized starch...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/12C08J3/24C08L3/04C08L5/16
CPCC08J3/12C08J3/246C08J2303/02C08J2405/16C08J2305/16C08J2403/02
Inventor 肖秀婵任亚琦高进长秦淼周筝黄娜陈翔宇
Owner CHENGDU TECHCAL UNIV
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