Enzyme-loaded bacterial cellulose-based composite antibacterial hydrogel dressing and preparation method thereof

Abstract

The present invention discloses an enzyme-loaded bacterial cellulose-based composite antibacterial hydrogel dressing and a preparation method thereof. A hydrogel layer is formed by free radical polymerization on a skeleton structure of bacterial cellulose to form an interpenetrating dual network structure by introducing a polymer of poly-N-isopropyl acrylamide, besides, the hydrogel layer is usedas a carrier to load a biological antibacterial agent, and thus the "ideal" medical wound hydrogel dressing with highly effective moisturizing and antibacterial functions is obtained. The obtained hydrogel dressing product has good swelling and mechanical properties, is relatively high in transparency, and a silicone layer plays a waterproof and breathable role and can maintain a closed and humidenvironment around wounds and in wound areas; and at the same time, the hydrogel layer has good actericidal and antibacterial properties to methicillin-resistant staphylococcus aureus and is conductive for resisting wound infections and promoting wound healing, besides, the skeleton material has a wide range of bacterial fiber raw materials, is low in price, good in histocompatibility and weak inantigenicity, does not cause foreign bodies, inflammation and rejection, and has good medical application prospects.

Description

technical field [0001] The invention belongs to the field of preparation and application of biomedical hydrogel, in particular to an enzyme-loaded bacterial cellulose-based composite hydrogel with antibacterial function and its preparation. Background technique [0002] Hydrogel medical dressing is a new type of wound dressing developed in recent years. It is mainly composed of high-molecular polymers that absorb water and swell to form a gel-like substance with a three-dimensional network structure. Its water content can be as high as 96%. Keep the wound moist. As a nanoscale fiber material, bacterial cellulose (BC) has good biocompatibility, high mechanical strength in wet state, good liquid and gas permeability, which is beneficial to the growth of skin tissue and can limit infection. It can be used as a A temporary skin substitute and a potential biological dressing. [0003] Check the medical device product database of the State Food and Drug Administration. Domestic ...

AI Technical Summary

Problems solved by technology

[0004] The above-mentioned dressings generally have various shortcomings, such as not being able to effectively kill pathogenic bacteria that cause wound infection, or not being able to effectively control and absorb wound exudate, especially gauze loaded with lysostaphin enzyme has poor moisture retention during clinical use, and is not suitable for use. convenience, disadvantages, etc.

Images