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Traditional Chinese medicine composition for treating advanced breast cancer and preparation method and application of traditional Chinese medicine composition

A technology for advanced breast cancer and composition, which is applied in the direction of drug combination, pharmaceutical formula, and medical preparations containing active ingredients, etc., which can solve the problems of difficulty in obtaining curative effect, poor prognosis, and large side effects

Inactive Publication Date: 2019-11-19
CHANGCHUN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Modern medical treatment measures for advanced breast cancer are difficult to achieve satisfactory curative effect, and there are disadvantages such as poor curative effect, poor prognosis, and large side effects

Method used

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  • Traditional Chinese medicine composition for treating advanced breast cancer and preparation method and application of traditional Chinese medicine composition
  • Traditional Chinese medicine composition for treating advanced breast cancer and preparation method and application of traditional Chinese medicine composition
  • Traditional Chinese medicine composition for treating advanced breast cancer and preparation method and application of traditional Chinese medicine composition

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preparation example Construction

[0030] The present invention also provides a preparation method of the Chinese medicine composition, comprising the following steps: mixing the raw materials according to the weight parts to obtain a Chinese medicine mixture; mixing the Chinese medicine mixture and water at a mass ratio of 1:6-8 Mixing, decocting, and filtering to obtain a Chinese medicine liquid; concentrating the Chinese medicine liquid to a relative density of 1.30-1.35 extract, drying under reduced pressure, and pulverizing into a Chinese medicine composition powder.

[0031] In the preparation method of the present invention, the decoction is preferably carried out under natural pressure, and the temperature of the decoction is preferably 70-100°C, more preferably 100°C. The decocting in the present invention is preferably carried out 2 to 3 times, and the time of each decocting is 1.8 to 2.5 hours, more preferably 2 hours. In the present invention, after each decoction, the decocted filter residue is col...

Embodiment 1

[0036] Weigh 5g ginseng, 20g astragalus, 10g Bupleurum, 5g Qingpinellia, 10g Angelica, 10g Atractylodes macrocephala, 10g Poria cocos, 10g Fritillaria japonicus, 5g Arrowhead mushroom, 20g raw oyster, 10g white peony root, 10g Trichosanthes mellifera and Zhinanxing 5g, add 6 times the amount of water, decoct 3 times under natural pressure, 2 hours each time, filter the decoction, combine the filtrate, concentrate to a relative density of 1.20-1.25 (60°C) extract, add appropriate amount of auxiliary materials, and prepare Soft material, sieved, dried, made into granules, containing 0.028% of the total amount of ginsenoside Rg1 and ginsenoside Re, not less than 0.012% of ginsenoside Rb1, not less than 0.0055% of astragaloside, containing saikosaponin The total amount of a and saikosaponin d is not less than 0.028%.

Embodiment 2

[0038] Weigh 10g of ginseng, 30g of astragalus, 20g of Bupleurum, 10g of Qing Pinellia, 20g of Angelica, 20g of Atractylodes macrocephala, 20g of Poria, 15g of Fritillaria, 10g of Arrowhead Mushroom, 30g of raw oyster, 20g of white peony, 20g of Trichosanthes and Zhinanxing 10g, add 7 times the amount of water, under natural pressure, decoct 3 times, 2 hours each time, filter the decoction, combine the filtrate, concentrate to a relative density of 1.30-1.35 (80 ℃) extract, dry under reduced pressure, grind into fine powder. Add excipients to make tablets, containing 0.030% of the total amount of ginsenoside Rg1 and ginsenoside Re, not less than 0.014% of ginsenoside Rb1, not less than 0.0068% of astragaloside, containing saikosaponin a and saikosaponin The total amount of d is not less than 0.035%.

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Abstract

The invention provides a traditional Chinese medicine composition for treating advanced breast cancer and a preparation method and application of the traditional Chinese medicine composition, and relates to the technical field of traditional Chinese medicine theory preparations. The traditional Chinese medicine composition comprises the following raw materials in parts by weight of 5-15 parts of ginseng, 20-40 parts of radix astragali, 10-30 parts of radix bupleuri, 5-15 parts of rhizoma pinelliae preparata, 10-30 parts of radix angelica sinensis, 10-30 parts of bighead atractylodes rhizomes,10-30 parts of poria cocos, 10-20 parts of thunberg fritillary bulbs, 5-15 parts of pseudobulbus cremastrae seu pleiones, 20-40 parts of fresh oyster shells, 10-30 parts of white peony roots, 10-30 parts of snakegourd fruits and 5-15 parts of prepared rhizoma arisaematis. A traditional Chinese medicine theory is used for guidance, soothing liver, regulating qi, replenishing qi to invigorate the spleen, dissipating phlegm and resolving masses are used as a treatment principle, the traditional Chinese medicine composition is used for treating advanced breast cancer (stagnation of liver qi, spleen deficiency and intermingled pathogenic phlegm and qi ), and the traditional Chinese medicine composition is mild in temperament, rigorous in compatibility, clear in pharmacodynamics substances, andnotable in clinical efficacy.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a traditional Chinese medicine composition for treating advanced breast cancer, a preparation method and application thereof. Background technique [0002] Breast cancer (Brest Cancer) is a malignant tumor derived from the epithelial tissue of the mammary gland, which is more common in women aged 40-60. "Global Cancer Statistics 2018" (Global Cancer Statistics 2018) shows that in terms of global cancer incidence and mortality, the incidence of breast cancer (11.6%) ranks second; the mortality rate (6.6%) ranks fifth; In the female group, both the incidence rate (24.2%) and the mortality rate (15%) of breast cancer rank first. According to statistics, in 2015, the incidence of breast cancer in my country ranked fifth in the incidence of malignant tumors, reaching 304,000 cases, and it is the most common malignant tumor among women. ...

Claims

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Application Information

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IPC IPC(8): A61K36/898A61P15/14A61P35/00A61K35/618
CPCA61K35/618A61K36/076A61K36/232A61K36/233A61K36/258A61K36/284A61K36/428A61K36/481A61K36/65A61K36/71A61K36/8884A61K36/8888A61K36/8966A61K36/898A61K2236/331A61K2236/39A61P15/14A61P35/00A61K2300/00
Inventor 旋静旋菲张文龙叶红李庆杰丁庆刚朱耀举孙牧王晓枫
Owner CHANGCHUN UNIV OF CHINESE MEDICINE
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