Functional microhelix and preparation method thereof

Abstract

The invention provides a preparation method for a functional micro-spiral. The method comprises the following steps: (1) injecting internal-phase, intermediate-phase and stable-phase fluids into a microfluid device, forming a monodisperse oil-in-water or water-in-water emulsion in a transition tube, enabling the monodisperse oil-in-water or water-in-water emulsion to enter a conversion tube, changing the stable-phase fluid into external-phase fluid after flowing is stable, cross-linking sodium alginate in the emulsion and calcium chloride in the external-phase fluid to form calcium alginate fibers, subjecting the calcium alginate fibers to spontaneous spiralization in the conversion tube to form spiral fibers, and subjecting oil cores or water cores of the spiral fibers to stretching at aconical outlet of the conversion tube and spiralization due to restriction of calcium alginate shells of the spiral fibers, so as to form a liquid droplet micro-spiral template; and (2) initiating polymerization of macromolecular monomers in the liquid droplet micro-spiral template to form a calcium alginate shell encapsulated functional micro-spiral, carrying out dissolving to remove a calcium alginate shell, so as to release the functional micro-spiral. According to the method, the continuous controllable preparation of the functional micro-spiral is achieved, and micro-spirals with diversified functions can be prepared.

Description

technical field [0001] The invention belongs to the field of polymer functional material preparation, and relates to a functional microhelix and a preparation method thereof. Background technique [0002] Due to its unique three-dimensional structure, microhelices have broad application prospects in the fields of biomedicine, tissue engineering, and material transport. The special helical structure of the microhelix can provide a template for the preparation of new materials; the flexible microhelix with tensile and compressive properties can be used as a micro biosensor; the magnetically modified microhelix can rotate and move forward under the drive of a three-dimensional rotating magnetic field, and can be used for target Drug delivery systems, cargo transport, thrombus clearance, cell manipulation, enhanced flow and mass transfer processes, and enhanced transwelling, etc. The structure of the microhelix has an important influence on its performance, and the application ...

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Problems solved by technology

However, this method prepares microhelixes by manually cutting the helical fibers, which is not suitable for mass production, and the strength of the calcium alginate helical fibers is poor, and the fibers are easily deformed during the shearing process, requiring fine operation and poor controllability. good

Combining the fluid rope effect in the microfluidic device and the mask-assisted flow etching technology, a certain amount of PEGDA and HMPP can be dissolved in the sodium alginate solution to prepare polyPEGDA microhelices, but this method requires different Masks are used to control the photoetching range, thereby controlling the length of the helical particles; at the same time, the change of the flow rate also requires an appropriate light frequency to achieve partial photoetching; and only polymer monomers that can be dissolved in sodium alginate solution can realize microcoils The preparation of the microhelix is ​​greatly restricted

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