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Injectable hydrogel material and preparation method and application thereof

A technology of gel material and injection water, which is applied in X-ray contrast agent preparation, pharmaceutical formulation, general/multifunctional contrast agent, etc., and can solve unfavorable post-injection gel fixed-point molding, long-term exercise tolerance, and biocompatibility Poor sex and biodegradability, slow coagulation of injectable hydrogels, etc., to achieve enhanced in vivo traceability, high integrity and adjustability, and good resistance to exercise fatigue

Active Publication Date: 2019-11-05
杭州碧泰生物医疗科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] In order to overcome the problems of slow coagulation, low strength, poor biocompatibility and biodegradability of the existing injectable hydrogel, which is not conducive to the fixed-point molding of the gel after injection and long-term exercise tolerance, the present invention provides a An injectable hydrogel material with good exercise tolerance, high biocompatibility and biodegradability, multimodal imaging and controllable degradation functions

Method used

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  • Injectable hydrogel material and preparation method and application thereof
  • Injectable hydrogel material and preparation method and application thereof
  • Injectable hydrogel material and preparation method and application thereof

Examples

Experimental program
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Embodiment 1

[0039] (1) Accurately weigh 10.0g chitosan and 10g sodium hydroxide in a three-necked flask, add 100mL isopropanol solvent, and swell at 50°C for 3 hours; accurately weigh 10.0g monochloroacetic acid and dissolve it in 20mL isopropanol middle. Slowly add chloroacetic acid solution dropwise into chitosan lye to react for 12 hours; pour 200mL of absolute ethanol to wash the product, filter and dry to obtain carboxymethyl chitosan;

[0040] (2) Accurately weigh 1.0 g of guar gum, dissolve it in 100 mL of water, add 10 mL of sodium periodate solution (0.1 g / mL) dropwise in the dark at room temperature, and react for 2 h. Centrifuge to remove slag, precipitate the product with ethanol, and dry to obtain bisaldehyde guar gum;

[0041] (3) Measure 10 mL of iohexol injection, add 1 mL of sodium periodate solution (0.1 g / mL) dropwise in the dark at room temperature and react for 1 hour; separate and purify by column chromatography to obtain an aldylated iohexol solution;

[0042] (4)...

Embodiment 2- Embodiment 5

[0048] The difference between Example 2-Example 5 and Example 1 is that in step (5), the formulation of component B is different, see Table 1, and the rest of the processes are identical.

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Abstract

The invention relates to the technical field of biomedical polymer material, and provides an injectable hydrogel material for solving the problems that existing injectable hydrogel is slow in condensation, low in strength, and poor in biocompatibility and biodegradability, and consequently fixed point forming and long-term exercise tolerance of the hydrogel after injection are not facilitated. Theinjectable hydrogel material is generated from a component A and a component B in-situ through isovolumetric injection by adopting dual-linking injection technology; and the component A is carboxymethyl chitosan, and the component B is prepared from reaction of double hydroformylation polysaccharide and an auxiliary cross-linking agent and a formylation contrast agent. According to the injectablehydrogel material, the exercise tolerance is good, the requirements of the biocompatibility and the biodegradability are met, the functions of multimoding development and controlled degradation are further achieved, the effect that the multiple functions of protection, tracing, customized treatment and the like are integrated is achieved, and the wide application prospects in the field of integration of diagnosis and treatment are achieved.

Description

technical field [0001] The invention relates to the technical field of medical polymer materials, in particular to an injectable hydrogel material and its preparation method and application. Background technique [0002] The integration of diagnosis and treatment is an emerging medical technology that organically combines the diagnosis and treatment of diseases. Through the combination of diagnostic components and therapeutic components, it is expected to realize accurate and timely treatment while detecting diseases to avoid further deterioration. This is especially important for cancer. Cancer treatments generally include surgery, chemotherapy, and radiotherapy. Chemotherapy and radiotherapy have serious side effects, and tumor tissue is difficult to identify during surgery. Therefore, targeted treatment of the lesion during the diagnosis period is expected to give timely and effective treatment in the early detection and reduce the chance of deterioration and spread. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/04A61K49/12A61K49/18A61K49/22A61K9/06A61K47/36C08B37/08C08J3/075C08L5/08C08L5/00
CPCA61K9/0024A61K9/06A61K47/36A61K49/0002A61K49/0457A61K49/12A61K49/1803A61K49/222C08B37/003C08J3/075C08J2305/08C08J2405/00
Inventor 王旭陈思王成严森祥吴凌云
Owner 杭州碧泰生物医疗科技有限责任公司
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