Mild low-temperature photothermal anti-tumor material GO-FA-SNX2112

Abstract

The embodiment of the invention discloses a mild low-temperature photothermal anti-tumor material GO-FA-SNX2112; a preparation method comprises the steps: uniformly dispersing GO in deionized water byultrasound to prepare a dispersed liquid; adding EDC to the dispersed liquid, and stirring; adding NHS and stirring, then mixing NaOH into the solution and adjusting the pH; mixing FA into the obtained solution; after stirring the obtained solution, removing DMSO by a dialysis method; dissolving SNX2112 in DMSO, dispersing to prepare a solution, and then dispersing GO-FA into deionized water to prepare a dispersed solution; mixing a heat shock protein inhibitor solution and the GO-FA dispersed solution evenly and stirring; and carrying out centrifugation washing of the product by PBS for multiple times, removing the free heat shock protein inhibitor, and finally, preparing GO-FA-SNX2112. The mild low-temperature photothermal anti-tumor material GO-FA-SNX2112 can target to a tumor tissue,plays the functions of activating overautophagy and promoting tumor immunity, and then makes tumor cells die.

Description

technical field [0001] The invention relates to an anti-tumor material, in particular to a mild low-temperature photothermal anti-tumor material GO-FA-SNX2112. Background technique [0002] Photothermal therapy has developed rapidly in the treatment of tumors, but because it also has a killing effect on normal tissues during the treatment process, its application in the clinical field is limited, and if it is adjusted to a lower temperature in order to protect normal tissues, the The tumor tissue cannot achieve the desired killing effect. [0003] This material uses the photothermal material graphene to load the heat shock protein inhibitor SNX-2112, which can inhibit the heat shock protein at a relatively low temperature, thereby inhibiting the AKT pathway and activating suicide autophagy, while inhibiting Under the joint action of excessive autophagy and activated tumor immunity, it can kill tumor tissue without affecting normal tissue. However, similar photothermal mate...

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the embodiments of the present invention is to propose a mild low-temperature photothermal anti-tumor material GO-FA-SNX2112 in view of the various limitations of current photothermal materials in the clinical field.

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