Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Technical method for treating leucoderma based on hair follicle melanocyte stem cell transplantation

A technology of melanocytes and stem cells, which is applied in the field of hair follicle melanocyte stem cell transplantation in the treatment of vitiligo, can solve the problems of long treatment course, inability to deal with the hair in the recolored area, and general curative effect, so as to ensure curative effect, promote proliferation and differentiation and organize the formation of the effect

Active Publication Date: 2019-10-18
NANHAI RENSHU INT SKIN HOSPITAL (HAINAN) CO LTD
View PDF3 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Vitiligo is an acquired skin and mucous membrane pigmentation disorder. The color recovery of skin lesions is mostly completed by the migration of melanocytes from other parts and the production of pigments. The repigmentation patterns of vitiligo skin lesions can be summarized as punctate, marginal, and uniform Vitiligo can be completely cured only by achieving punctate recoloration. The common treatment methods for vitiligo in clinical practice mainly include traditional Chinese medicine treatment, corticosteroid and other western medicine treatment, photochemical therapy (308 excimer laser) and epidermis transplantation. , the first two treatment measures vary from person to person, and if Chinese medicine is used for treatment, the course of treatment is long and the curative effect is uncertain. At the same time, some patients have relatively large side effects after taking the medicine, such as nausea, vomiting, loss of appetite, etc. , as for the treatment of corticosteroid hormones, the curative effect is unstable and easy to relapse; epidermal transplantation, one of the commonly used methods at present, is unstable and easy to relapse because of the uniform recoloration; 308 excimer laser treatment cycle is long, the curative effect is average, and the side effects are large , even if the recoloring effect is unstable, and the color is not uniform, the disadvantages of the existing technology: (1) can only achieve pigment regeneration around a single hair follicle, and a large number of hair follicle transplants are needed to recolor, and the treatment of vitiligo with moderate area or more cannot be completed; (2) After hair follicle implantation, it is impossible to deal with the hair growing in the recolored area, and to treat the head, face and body hypertrichosis. Therefore, the technical method of hair follicle melanocyte stem cell transplantation for the treatment of vitiligo is provided, and the existing problems are further improved. Improve

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Technical method for treating leucoderma based on hair follicle melanocyte stem cell transplantation
  • Technical method for treating leucoderma based on hair follicle melanocyte stem cell transplantation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Such as figure 1 As shown, the present invention provides a kind of technical scheme: the technical method of hair follicle melanocyte stem cell transplantation treatment vitiligo, this technical method comprises the following steps:

[0030] Step S1, hair follicle extraction, using FUE technology to extract a hair follicle unit;

[0031] Step S2, separating the hair follicles, separating the hair follicle units into individual hair follicles under an electron microscope;

[0032] Step S3, in vitro culture of hair follicles, the extracted and isolated single hair follicles are put into special culture medium for cultivation and standby, and the cultivation is carried out to improve the survival rate of hair follicles;

[0033] Step S4, inactivation of hair follicles, inactivating hair follicles before transplantation with the aid of a dermatoscope and a hair follicle inactivation needle;

[0034] Step S5, transplantation of hair follicles. After the hair follicles are...

Embodiment 2

[0042] Such as figure 2 As shown, the technical method of hair follicle melanocyte stem cell transplantation provided by the present invention for the treatment of vitiligo, through the technical method in Example 1, transplants hair follicle melanocyte stem cells to specific areas of leukoplakia, promotes the proliferation and differentiation of melanocytes and organizes The formation of point-like multiple hair follicles can be achieved, so as to achieve the purpose of rapid whitening.

[0043] In this example, the cure rate of vitiligo treated by hair follicle melanocyte stem cell transplantation reached over 95%.

[0044] Technical difficulties and operation steps of the present invention:

[0045]Technical difficulties: "Survival rate" refers to whether the melanocyte stem cells can survive directly after planting, which is related to the later treatment effect, and the autologous melanocyte stem cells obtained after extraction have the characteristics of not being affe...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a technical method for treating leucoderma based on hair follicle melanocyte stem cell transplantation. The technical method includes the following steps of extraction of hairfollicles, wherein a hair follicle unit is extracted by using an FUE technology; separation of the hair follicles, wherein individual follicalar units are separated from the hair follicle unit under an electron microscope; in-vitro culture of the hair follicles, wherein the extracted and separated individual follicalar units are cultured in a special culture medium for use to improve the survivalrate of the hair follicles; inactivation of the hair follicles, wherein the hair follicles before transplantation are inactivated with the help of a dermatoscope and a hair follicle inactivating needle; transplanting of the hair follicles, wherein a special planting needle is used for planting the inactivated hair follicles in a specific area of leukasmus. Through the hair follicle in-vitro culture technology, the FUE technology is used for extracting and separating the individual follicalar units, then the individual follicalar units are placed in the special culture medium for culture, and the inactivation of the hair follicles is achieved through the hair follicle inactivation technology. After an operation, the hair follicles only turn black and do not grow hair, the point-like multiple hair follicles can restore original color through precise planting, and the purpose of fast removing the leukasmus is achieved.

Description

technical field [0001] The invention relates to the technical field of hair follicle transplantation, in particular to a technical method for treating vitiligo with hair follicle melanocyte stem cell transplantation. Background technique [0002] Vitiligo is an acquired skin and mucous membrane pigmentation disorder. The color recovery of skin lesions is mostly completed by the migration of melanocytes from other parts and the production of pigments. The repigmentation patterns of vitiligo skin lesions can be summarized as punctate, marginal, and uniform Vitiligo can be completely cured only by achieving punctate recoloration. The common treatment methods for vitiligo in clinical practice mainly include traditional Chinese medicine treatment, corticosteroid and other western medicine treatment, photochemical therapy (308 excimer laser) and epidermis transplantation. , the first two treatment measures vary from person to person, and if Chinese medicine is used for treatment, ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K35/36A61P17/00C12N5/071
CPCA61K35/36A61P17/00C12N5/0625
Inventor 刘景卫
Owner NANHAI RENSHU INT SKIN HOSPITAL (HAINAN) CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products