A method for simultaneous determination of 9 kinds of sulfonamide antibiotics on suspended particulate matter in water
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A technology for suspended particles and sulfonamides, applied to measuring devices, instruments, scientific instruments, etc., can solve the problems of unreported analysis methods of sulfonamide antibiotics and low content of sulfonamide antibiotics, and achieve the effect of short processing time and simple steps
Active Publication Date: 2022-04-01
INSTITUTE OF ANALYSIS GUANGDONG ACADEMY OF SCIENCES (CHINA NATIONAL ANALYTICAL CENTER GUANGZHOU)
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[0004] However, due to the structural characteristics of sulfonamide antibiotics, the content of sulfa antibiotics in suspended particles in water is extremely low, and there is no report on the analysis method for sulfonamide antibiotics on suspended particles in water.
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[0029] A method for simultaneously measuring 9 kinds of sulfonamide antibiotics on suspended particulate matter in surface water, its specific implementation steps are as follows:
[0030] Step 1. Take 10L of the target water sample, filter it with a 0.45μm microporous fiber filter membrane, collect the particles intercepted by the filter membrane and the surface after filtration, and add 200μL of internal standards (deuterated sulfadiazine and deuterated sulfa-metaformazine) to the filter membrane Oxypyrimidine, dilute its concentration to 1mg / L with methanol, add 100 μ L respectively), freeze-dry, cut into pieces and place in a centrifuge tube, add an appropriate amount of acetonitrile solution containing 1vol.% formic acid as an extraction agent, and shake at a constant temperature 10°C, speed 165 times / min) after 3-4 hours, weak ultrasonic (using ultrasonic cleaner, power 500W) ultrasonic 10-20min and strong ultrasonic (using ultrasonic cell disruptor, power 280W, interval ...
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Abstract
The invention discloses a method for simultaneously measuring nine kinds of sulfonamide antibiotics on suspended particles in water, which comprises the following steps: taking a target water sample, filtering, collecting the particles intercepted by the filter membrane and the surface after filtration, adding a quantitative internal standard substance, and freeze-drying Then cut it into pieces and put it in a centrifuge tube, add an appropriate amount of extractant, shake at constant temperature, ultrasonic, centrifuge, transfer the supernatant to a K‑D concentration bottle, purge the extract volume to less than 1mL with nitrogen gas, and filter it with an organic microporous membrane , measured with an ultra-high performance liquid chromatography-triple quadrupole tandem mass spectrometer, the sample pretreatment time of the present invention is short, and the steps are simple, and can simultaneously measure sulfadiazine, sulfapyridine, sulfamethazine, and sulfamethazine adsorbed on suspended particles in water The content of 9 sulfa antibiotics, sulfamethazine, sulfachloropyridazine, sulfamethazine, sulfamethoxazole, sulfaquinoxaline and trimethoprim, more accurately and truly reflects the content of sulfa antibiotics in water .
Description
Technical field: [0001] The invention relates to the technical field of water environment detection, in particular to a method for simultaneously measuring nine kinds of sulfonamide antibiotics on suspended particles in water. Background technique: [0002] Sulfonamide antibiotics are derivatives containing p-aminobenzenesulfonamide structure. They are one of the most widely used antibiotics. They have a wide antibacterial spectrum and have inhibitory effects on most Gram-positive and Gram-negative bacteria. Due to the widespread use of sulfonamide antibiotics and incomplete absorption and metabolism in target organisms, they continue to enter the environment and produce a series of metabolic and degradation products through adsorption, hydrolysis, photodegradation and biodegradation, and these products often have Greater toxicity. [0003] At present, the prevalence of antibiotics including sulfonamide antibiotics has been continuously detected in different water bodies in...
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