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Medical composition based on Fushiming capsules and application of medical composition to treatment of diabetic eye diseases

A diabetic eye disease and composition technology, applied in the field of pharmacy, can solve the problems of low separation of chemical components and complex components of Fushiming Capsules, and achieve the effect of optimizing components and maintaining drug efficacy

Pending Publication Date: 2019-10-08
XIAN LEJIAN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complex composition of Fushiming Capsules and the low separation of chemical components under general conditions, there are few research reports on the active ingredients of Fushiming Capsules. The common mode of HPLC fingerprint of Shiming capsules, 33 common peaks were calibrated, and the similarity was 0.994-1.000; and 5-HMF, puerarin, 3'-methoxypuerarin, daidzin , formononetin, daidzein, orange cassiatin, ligustilide content

Method used

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  • Medical composition based on Fushiming capsules and application of medical composition to treatment of diabetic eye diseases
  • Medical composition based on Fushiming capsules and application of medical composition to treatment of diabetic eye diseases
  • Medical composition based on Fushiming capsules and application of medical composition to treatment of diabetic eye diseases

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The establishment of embodiment 1 fingerprint

[0021] 1. Instruments, materials and reagents

[0022] 1.1 Instruments and materials

[0023]

[0024] 1.2 Drugs and reagents

[0025] Fushiming Capsules (Xi'an Lejian Biotechnology Co., Ltd., batch number: 20180506, 20180507, 20180508, 20180605, 20180508, 20180509, 20180607, 20180608, 20180609, 20180610, specification: 400mg / capsule) (S1~S10); Methylfurfural reference substance (batch number: 111626-201610, purity: 99.2%), puerarin reference substance (batch number: 110752-201615, purity: 95.4%), daidzin reference substance (batch number: 111738-201603, purity: 93.3%) ), orange cassiatin reference substance (batch number: 111900-201605, purity: 98.3%), and ligustilide reference substance (batch number: 111737-201608, purity: 99.2%) were purchased from China National Institutes for Food and Drug Control. Formononetin reference substance (batch number: 486-62-4, purity: 98.0%), 3'-methoxypuerarin reference substance (...

Embodiment 2

[0070] Example 2 Pharmacodynamic studies of 8 kinds of component pharmaceutical compositions

[0071] 1. Instruments, materials and reagents

[0072] 1.1 Instruments and materials

[0073]

[0074]

[0075] 1.2 Drugs and reagents

[0076] Fushiming Capsule Powder, provided by the Institute of Drug Research, Air Force Military Medical University, batch number 20170301. Calcium dobesilate capsules are commercial products, batch number: 20161104, produced by Guizhou Tianan Pharmaceutical Co., Ltd., approval number: Guoyao Zhunzi H20010481. 5-Hydroxymethylfurfural reference substance (batch number: 111626-201610, purity: 99.2%), puerarin reference substance (batch number: 110752-201615, purity: 95.4%), daidzein reference substance (batch number: 111738-201603, purity: 93.3%), orange cassiacin reference substance (batch number: 111900-201605 , purity: 98.3%), ligustilide reference substance (batch number: 111737-201608, purity: 99.2%) were purchased from China National Ins...

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Abstract

The invention relates to a medical composition based on Fushiming capsules and an application of the medical composition to treatment of diabetic eye diseases. Through research on the fingerprint spectrum of the Fushiming capsules at the early stage, 8 effective components are determined and are optimized so that the medical composition is obtained. The medical composition comprises the followingeffective components in parts by weight of 2.0-3.0 parts of 5-HMF, 8.0-10.0 parts of puerarin, 5.0-8.0 parts of 3'-methoxy puerarin, 4.0-6.0 parts of daidzin, 0.3-0.5 part of ononin, 1.0-1.5 parts ofdaidzein, 0.6-1.0 part of aurantio-obtusin and 1.4-2.0 parts of ligustilide. The medical composition has equivalent effects in the respect of preventing the retina of a diabetic rat from becoming weakto positive medicines (calcium dobesilate) and the Fushiming capsules.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a pharmaceutical composition based on Fushiming capsule and its application in treating diabetic eye disease. Background technique [0002] The prescription of Fushiming Capsules is based on the clinical experience of preparations in Xijing Hospital of Fourth Military Medical University. Diabetic fundus retinopathy. Due to the complex composition of Fushiming Capsules and the low separation of chemical components under general conditions, there are few research reports on the active ingredients of Fushiming Capsules. The common mode of HPLC fingerprint of Shiming capsules, 33 common peaks were calibrated, and the similarity was 0.994-1.000; and 5-HMF, puerarin, 3'-methoxypuerarin, daidzin , formononetin, daidzein, orange cassiatin, ligustilide content. And the pharmacological activity of the 8 kinds of ingredients pharmaceutical composition was preliminarily evaluated. In ...

Claims

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Application Information

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IPC IPC(8): A61K31/122A61K31/341A61K31/352A61K31/365A61K31/7048A61P3/10A61P9/10A61P27/02
CPCA61K31/352A61K31/7048A61K31/122A61K31/365A61K31/341A61P3/10A61P27/02A61P9/10A61K2300/00
Inventor 王四旺何萌杉许璐张明科
Owner XIAN LEJIAN BIOTECH CO LTD
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