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SNP marker for colorectal cancer auxiliary diagnosis and application of SNP marker

A technology for auxiliary diagnosis and colorectal cancer, applied in the field of genetic engineering and tumor medicine, can solve the problems affecting the modification process, tumor occurrence and susceptibility, etc., and achieve the effect of accurate and reliable results, ingenious design, and auxiliary diagnosis

Inactive Publication Date: 2019-09-27
HUAZHONG UNIV OF SCI & TECH
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Problems solved by technology

due to m 6 A modification occurs at the RNA level, so if the corresponding coding region DNA contains genetic variation, it will significantly affect the gene m 6 Modification process of A modification, thereby affecting tumorigenesis and susceptibility

Method used

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  • SNP marker for colorectal cancer auxiliary diagnosis and application of SNP marker
  • SNP marker for colorectal cancer auxiliary diagnosis and application of SNP marker
  • SNP marker for colorectal cancer auxiliary diagnosis and application of SNP marker

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Embodiment Construction

[0015] The principles and features of the present invention are described below, and the examples are only used to explain the present invention, but not to limit the scope of the present invention.

[0016] The technical scheme that the present invention solves the above-mentioned technical problems is as follows:

[0017] An SNP marker for auxiliary diagnosis of colorectal cancer, the marker is the combination of rs8100241.

[0018] In the above-mentioned specific amplification primers for SNP markers for auxiliary diagnosis of colorectal cancer, the specific amplification primer sequences for rs8100241 are SEQ ID NO: 1 and SEQ ID NO: 2.

[0019] In the above-mentioned specific probe of SNP marker for auxiliary diagnosis of colorectal cancer, the probe sequences of rs8100241 are SEQ ID NO: 3 and SEQ ID NO: 4.

[0020] The application of the above SNP markers in the preparation of colorectal cancer auxiliary diagnosis kits.

[0021] An auxiliary diagnostic kit for colorecta...

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Abstract

The invention relates to an SNP marker for colorectal cancer auxiliary diagnosis and an application of the SNP marker. The marker is rs8100241. Ingenious primer and probe design is performed for the rs8100241 site, ANKLE1 gene mutation of normal people can be detected by relying on fluorescence quantitative PCR, and accordingly, high-risk groups of rectal cancer are identified, and auxiliary diagnosis of rectal cancer patients is achieved. The technical method is ingenious in design, simple, implementable and accurate and reliable in result, can be popularized in hospitals at all levels, provides help for evaluating the risk of rectal cancer, and is conducive to clinical rectal cancer screening and early intervention for the groups.

Description

technical field [0001] The invention relates to the fields of genetic engineering and tumor medicine, in particular to a colorectal cancer auxiliary diagnosis SNP marker and its application. Background technique [0002] Colorectal cancer is a common malignant tumor that seriously threatens the health of the Chinese people, and its incidence ranks fifth among malignant tumors in my country. Currently, the most effective screening method for colorectal cancer is colonoscopy. However, this method also has problems such as low detection rate and low patient acceptance. If screening and early diagnosis of high-risk individuals with colorectal cancer can be carried out more accurately, it can make patients more acceptable and save a lot of medical expenditures for the country. [0003] N6-Methyladenosine modification of RNA (referred to as m 6 A modification) is a post-transcriptional regulation that has received extensive attention in recent years, which can affect the RNA an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886C12N15/11
CPCC12Q1/6886C12Q2600/156
Inventor 缪小平常江钟荣田剑波朱颍
Owner HUAZHONG UNIV OF SCI & TECH
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