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A kind of hemostatic and osteogenic integrated material and its preparation method and application

A technology of osteogenesis and bioceramic materials, which is applied in the field of medical materials, can solve the problems of bone wax without osteogenesis properties, and achieve the effects of avoiding foreign body reactions, improving osteogenesis effects, and strengthening impact resistance properties

Active Publication Date: 2021-08-03
南京纳铠生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Also, bone wax does not have very good osteogenic properties

Method used

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  • A kind of hemostatic and osteogenic integrated material and its preparation method and application
  • A kind of hemostatic and osteogenic integrated material and its preparation method and application
  • A kind of hemostatic and osteogenic integrated material and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1: Preparation of the integrated material of the present invention and its in vitro hemostatic test

[0040] 1. Preparation method

[0041] A, the preparation of starch gel precursor

[0042] Dissolve calcium nitrate in deionized water at 25% by mass to obtain an electrolyte solution; add cornstarch to the prepared electrolyte solution at 75% by mass, and stir fully at a temperature of 80°C until the starch is completely gelatinization to obtain viscous liquid;

[0043] Place the obtained viscous liquid in a high-temperature drying cabinet overnight until it is completely dry, then beat it into a powdery solid with a pulverizer, and pass through a 60-mesh sieve.

[0044] B. Preparation of Bioceramic Bone Glue Precursor

[0045] Weigh 60% tetracalcium phosphate, 20% pregelatinized starch and 20% hydroxyapatite.

[0046] Mix all three evenly.

[0047] C. Preparation of integrated materials

[0048] The bioceramic bone glue precursor is mixed with the starch ...

Embodiment 2

[0066] Example 2: Preparation of the integrated material of the present invention and its in vitro osteogenesis induction test

[0067] 1. Preparation method

[0068] A, the preparation of starch gel precursor

[0069] Dissolve magnesium chloride in deionized water at 10% by mass to obtain an electrolyte solution; add waxy starch to the prepared electrolyte solution at 90% by mass, and stir fully at a temperature of 80°C until the starch is completely gelatinization to obtain viscous liquid;

[0070] Place the obtained viscous liquid in a high-temperature drying cabinet overnight until it is completely dry, then beat it into a powdery solid with a pulverizer, and pass through a 60-mesh sieve.

[0071] B. Preparation of Bioceramic Bone Glue Precursor

[0072] Weigh 60% tricalcium phosphate, 20% corn starch and 20% bioactive glass.

[0073] Mix all three evenly.

[0074] C. Preparation of integrated materials

[0075] The bioceramic bone glue precursor was mixed with the s...

Embodiment 3

[0097] Example 3: Preparation of the integrated material of the present invention and its hemostasis and osteogenesis test in mice

[0098] 1. Preparation method

[0099] A, the preparation of starch gel precursor

[0100]Dissolve calcium chloride in deionized water at 12.5% ​​by mass to obtain an electrolyte solution; add potato starch to the prepared electrolyte solution at 87.5% by mass, and stir fully at a temperature of 80°C until the starch Completely gelatinized to obtain viscous liquid;

[0101] Place the obtained viscous liquid in a high-temperature drying cabinet overnight until it is completely dry, then beat it into a powdery solid with a pulverizer, and pass through a 60-mesh sieve.

[0102] B. Preparation of Bioceramic Bone Glue Precursor

[0103] Weigh 80% tricalcium silicate and 20% pregelatinized starch.

[0104] Mix the two evenly.

[0105] C. Preparation of integrated materials

[0106] The bioceramic bone glue precursor is mixed with the starch gel pr...

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Abstract

The invention relates to the technical field of medical materials, and discloses a hemostasis and osteogenesis integrated material, a preparation method and an application thereof. The present invention includes bioceramic bone glue precursors and starch gel precursors. The present invention adds a starch gel precursor in the process of bioceramic preparation, and provides a bioceramic-based integrated material for hemostasis and osteogenesis. Some anti-impact properties, combined with bioceramic bone glue, realized the improvement of osteogenic effect; the integrated material of the present invention has good operability and plasticity, and the biodegradable characteristics and biocompatibility of bioceramic and starch make it possible to Avoid foreign body reactions and stimulate granuloma growth. In addition, other functional drugs or materials can be added to the integrated material of the present invention as required to meet the needs of various diseases.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a hemostatic and osteogenic integrated material, a preparation method and application thereof. Background technique [0002] Orthopedic surgery is a discipline based on surgical treatment. Bleeding is a dangerous complication in the process of surgical treatment. Excessive blood loss during surgery can lead to unstable vital signs, even hemorrhagic shock or compressive hematoma, which is extremely detrimental to the recovery of the patient's prognosis; on the other hand, A large amount of intraoperative blood loss affects the clarity of the surgical field of view, which is not conducive to the development of the surgical process. With the development of hemostatic devices and new hemostatic materials, intraoperative hemostasis control measures have become more mature and perfect. However, due to special circumstances such as bone marrow oozing, adjacent nerve sheath b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/00A61L24/02A61L24/08A61L27/02A61L27/10A61L27/20A61L27/50A61L27/52A61L27/54
CPCA61L24/0031A61L24/02A61L24/08A61L27/025A61L27/10A61L27/20A61L27/50A61L27/52A61L27/54A61L2400/04A61L2430/02C08L3/02
Inventor 葛隽杨世童徐文
Owner 南京纳铠生物医药科技有限公司
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