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Application of curcuma longaextract in preparation of antagonizing drug-resistanceacinetobacter baumannii medicine

A technology of Acinetobacter baumannii and turmeric extract, which is applied to antibacterial drugs, plant/algae/fungus/moss components, pharmaceutical formulas, etc., to achieve good bactericidal effect, convenient operation and low price

Pending Publication Date: 2019-09-24
GENERAL HOSPITAL OF SOUTHERN THEATRE COMMAND OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the anti-drug-resistant bacteria of turmeric extract in vivo

Method used

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  • Application of curcuma longaextract in preparation of antagonizing drug-resistanceacinetobacter baumannii medicine
  • Application of curcuma longaextract in preparation of antagonizing drug-resistanceacinetobacter baumannii medicine

Examples

Experimental program
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Embodiment 1

[0026] The preparation of embodiment 1 turmeric extract and the detection of antibacterial activity thereof

[0027] 1. Experimental method

[0028] 1. Preparation of Turmeric Extract

[0029] Take by weighing three parts of turmeric, each part of 2g, place respectively in three 100mL round bottom flasks, press 1:12 material ratio, add water, 50% ethanol, 95% ethanol three kinds of different solvents 24mL respectively; Three different The flasks of the extraction solution were set at different extraction temperatures of 100°C, 90°C, and 85°C, and the liquid was filtered after heating and refluxing for 1.5 hours; Extract at ℃ and 85℃ for 1.5h, filter and combine all the medicinal solutions, evaporate all the solvents under reduced pressure to obtain the medicinal extract, weigh and place in a 1.5mL centrifuge tube, and place in a -20℃ refrigerator for later use. Three kinds of turmeric extracts (water extract of turmeric, 50% ethanol extract of turmeric, 95% ethanol extract o...

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Abstract

The invention discloses an application of a curcuma longa extract in preparation of anantagonizing drug-resistance acinetobacter baumannii medicine. The curcuma longa extract is utilized to treat a nematode infected with the drug-resistanc eacinetobacter baumannii, and it is showed that the curcuma longa extract has a good bactericidal effect on the drug-resistance acinetobacter baumannii. A good foundation for early research is provided for researching and developing of a novel antagonizing drug-resistance acinetobacter baumannii medicine, and dawn is brought to solve the dilemma that no medicine is available for drug-resistance acinetobacter baumannii infection. The curcuma longa extract is used for controlling the drug-resistance acinetobacter baumannii, the method is rapid and cheap, and the operation is convenient.

Description

technical field [0001] The invention relates to the field of biotechnology, more specifically, relates to the application of turmeric extract in the preparation of anti-drug-resistant Acinetobacter baumannii medicaments. Background technique [0002] Acinetobacter baumannii is the most common non-fermenting Gram-negative bacterium in the Acinetobacter genus. The bacteria can survive for a long time in the hospital environment, and the distribution of clinical departments is mainly in the ICU, followed by the Department of Respiratory Medicine. Elderly patients, patients with weak body resistance and critical illness, as well as patients who use various invasive procedures and long-term treatment with broad-spectrum antibiotics are susceptible objects. Acinetobacter baumannii has the ability to rapidly acquire and spread drug resistance, drug-resistant Acinetobacter baumannii presents a worldwide epidemic trend, and has become one of the most important pathogenic bacteria in...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P31/04
CPCA61K36/9066A61P31/04A61K2236/331
Inventor 姜志辉李健石磊袁进季波黄涛阳黄木土蔡敏捷
Owner GENERAL HOSPITAL OF SOUTHERN THEATRE COMMAND OF PLA
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