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Polysiloxane block polyether for preparing decoquinate emulsions and synthesizing method thereof

A polysiloxane block and decoquinate technology, which is applied in the fields of emulsion delivery, active ingredients of heterocyclic compounds, and pharmaceutical formulations, can solve the problem of large solid particles that are difficult to absorb, uneven dispersion of solid particles, and bioavailability No high problems, achieve good anti-coccidial effect, disperse without precipitation, and reduce the effect of oil-water interfacial tension

Active Publication Date: 2019-09-20
CHONGQING ACAD OF ANIMAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since the decoquinate solution is a strong acid solution, it is highly irritating when taken orally, and it is diluted with water to cause uneven dispersion of the precipitate; the decoquinate premix solid particles are large and difficult to absorb, and the uneven dispersion bioavailability is not high; Decoquinate dry suspension has defects such as easy precipitation, uneven dispersion of solid particles and unstable curative effect, and the problem of decoquinate dosage form has not been resolved.

Method used

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  • Polysiloxane block polyether for preparing decoquinate emulsions and synthesizing method thereof
  • Polysiloxane block polyether for preparing decoquinate emulsions and synthesizing method thereof
  • Polysiloxane block polyether for preparing decoquinate emulsions and synthesizing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Synthetic polysiloxane block polyether emulsifier comprises the following steps:

[0023] ⑴ Hydrosilation reaction

[0024] Weigh 20 g of hydrogen-containing silicone oil (hydrogen content 0.185%), 14.00 g of isopropanol, and 60 ppm of chloroplatinic acid into a four-necked flask equipped with a dropping funnel, a spherical condenser, a thermometer, and a stirrer, and heat to 120° C.; Weigh 15.00 g of allyl polyoxyethylene polyoxypropylene ether and 3.20 g of acrylamide and mix them, then add them to the above-mentioned hydrogen-containing silicone oil system at 120°C and slowly add them dropwise for two hours to react. After the dropwise addition, continue to react at 120°C for 4 hours ;

[0025] ⑵Separation of polysiloxane block polyether emulsifier

[0026] After the hydrosilylation reaction was completed, the reaction product was poured into a separatory funnel and dissolved with 50ml chloroform, then dissolved with 0.05mol / L Na 2 CO 3 Adjust the pH of the solut...

Embodiment 2

[0032] Synthetic polysiloxane block polyether emulsifier comprises the following steps:

[0033] ⑴ Hydrosilylation reaction

[0034] Weigh 25g of hydrogen-containing silicone oil (hydrogen content 0.185%), 18.00g of isopropanol, and 60ppm of chloroplatinic acid into a four-necked flask equipped with a dropping funnel, a spherical condenser, a thermometer, and a stirrer, and heat to 130°C; Weigh 21.00 g of allyl polyoxyethylene polyoxypropylene ether and 4.20 g of acrylamide and mix them, then add them to the hydrogen-containing silicone oil system at 130°C and slowly add them dropwise for two hours to react. After the dropwise addition, continue to react at 120°C for 5 hours ;

[0035] ⑵Separation of polysiloxane block polyether emulsifier

[0036] After the hydrosilylation reaction was completed, the reaction product was poured into a separatory funnel and dissolved with 50ml of chloroform, then dissolved with 0.09mol / L Na 2 CO 3 Adjust the pH of the solution to neutral, ...

Embodiment 3

[0038] The decoquinate emulsion made by the polysiloxane block polyether emulsifier of the present invention has been compared with two kinds of anticoccidial drugs of decoquinate premix and decoquinate solution, to verify The emulsifier of the present invention has an anti-coccidial effect of the decoquinate emulsion.

[0039]The spare chickens for the test were weighed one by one. According to the results of biostatistical analysis, the individuals with significant weight differences were eliminated so that the weight range was between 110-125g. Each chicken was marked with a foot number and randomly divided into 6 groups with 15 chickens in each group. , so that the total body weight of each group of chickens is approximately equal. The Ⅰ group is the non-infected non-medication group (white control group), the Ⅱ group is the infection non-medication group (red control group), the Ⅲ, Ⅳ, Ⅴ, and Ⅵ groups are the decoquinate drug groups, and the same dosage is administered res...

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Abstract

The invention provides a polysiloxane block polyether for preparing decoquinate emulsions. The polysiloxane block polyether for preparing the decoquinate emulsions can serve as an emulsifier to prepare the decoquinate emulsions, which have the advantages of being small in grain size, uniform in dispersion, free from precipitation, low in oral irritation and high in bioavailability. The prepared decoquinate emulsions prepared with the polysiloxane block polyether are significantly higher than decoquinate premixes and similar to decoquinate solutions in anticoccidial index. The synthesizing method of the polysiloxane block polyether for preparing the decoquinate emulsions saves large industrial equipment and is simple in operation and applicable to industrial production.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, and in particular relates to a polysiloxane block polyether for preparing decoquinate emulsion and a synthesis method thereof. Background technique [0002] Chicken coccidiosis (Coccidiosis in Chicken) is a common and very serious parasitic disease in chickens. It is an acute epidemic parasitic disease caused by one or more coccidiosis, and the economic loss it causes is staggering. The morbidity and mortality of 10-30-day-old chicks or 35-60-day-old young chickens can be as high as 80%. The growth of the sick chicks is hindered, and the weight gain is slow; the adult chickens generally do not get sick, but they are carriers, and the weight gain and egg production ability are reduced, which is an important source of spreading coccidiosis. Decoxyquinate (Decoquinate) is a quinoline anticoccidial drug, milky white or light yellow particle powder, insoluble in water and ethanol, slightly...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G81/00A61K9/107A61K31/47A61K47/34A61P31/04
CPCA61K9/107A61K31/47A61K47/34A61P31/04C08G81/00
Inventor 陈诚李成洪伍涛邓余唐达唐红梅
Owner CHONGQING ACAD OF ANIMAL SCI
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