In-situ-forming self-repairing antibacterial hydrogel and preparation method thereof

Abstract

The invention relates to in-situ-forming self-repairing antibacterial hydrogel and a preparation method thereof. The medical hydrogel dressing with functions of fast in-situ forming, self-repairing and bacterium resisting is prepared by combining oxidized formyl sodium hyaluronate of different molecular weights and sodium hyaluronate of different molecular weights. Formyl has reaction with amino in polycation polymer to form dynamic Schiff base bonds which allows the hydrogel to have the self-repairing function, and free sodium hyaluronate of different molecular weights plays a synergistic role to promote skin repairing. The hydrogel is simple and convenient in preparation method, capable of achieving injection in-situ forming and promising in application prospect in the field of biological medical materials.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to an in-situ forming self-repairing antibacterial hydrogel and a preparation method thereof. Background technique [0002] In daily life, people's skin is often damaged by burns, scalds and mechanical trauma, as well as skin damage caused by diabetic feet and pressure sores. Wound healing is a complex physiological process consisting of three overlapping phases: an inflammatory phase, a proliferative phase and a remodeling phase. The healing process begins when tissue is damaged. When blood components contact the site of injury, platelets come into contact with collagen, extracellular matrix and release clotting and growth factors. During the inflammatory phase, neutrophils are the first leukocytes to appear at the site of injury to eliminate bacterial contamination. During the proliferative phase, monocytes and their transformation into macrophages initiate tissue repair by ...

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Problems solved by technology

[0006] The Chinese invention patent application with the publication number CN108904875A discloses an antibacterial self-healing hydrogel auxiliary material for promoting chronic wound healing and its preparation method and application. The temperature-sensitive material F127 is added to the hydrogel. The auxiliary material needs After incubating in a water bath at 37°C for 1 hour, a hydrogel with a double network structure is formed, which takes a long time to gel and is inconvenient for clinical operation

[0007] The Chinese invention patent application with the publication number CN104892962B discloses a preparation method and application of a thiol / disulfide bond-controlled self-crosslinking hyaluronic acid hydrogel. As a raw material, a controllable injectable smart hydrogel with a good three-dimensional network crosslinking structure was constructed by using the redox transition characteristics between sulfhydryl groups and disulfide bonds. The shortest gelation time at 37°C was 6 minutes , long gelation time, inconvenient for clinical operation

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