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Application of Dendropanax proteus extract in preparation of anti-depression natural drugs

An extract and anti-depressant technology, which can be used in drug combinations, pharmaceutical formulas, plant raw materials, etc., can solve the problems of little research on ginseng, and achieve the effect of wide anti-depressant effect and small side effects

Active Publication Date: 2019-09-20
珠海俊一健生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, little research has been done on ginseng

Method used

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  • Application of Dendropanax proteus extract in preparation of anti-depression natural drugs
  • Application of Dendropanax proteus extract in preparation of anti-depression natural drugs
  • Application of Dendropanax proteus extract in preparation of anti-depression natural drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The preparation of the petroleum ether extract (hereinafter referred to as the Ginseng variable leaf extract) after the ethanol extraction of the ginseng of embodiment 1

[0019] Take 5kg of ginseng stems, crush them, add purified water (liquid-solid ratio: 3mL:1g), heat to boiling, keep for 5 hours, filter, concentrate the filtrate to 1 / 3 of the original volume, cool to room temperature, and At 18-23°C, slowly add 95% mass concentration of ethanol while stirring to extract twice, each extraction for 14 hours (the amount of ethanol is twice the volume of the filtrate after concentration), and then use 70%-75% mass concentration of ethanol (The amount of ethanol is twice the volume of the filtrate after concentration) extract 3 times, extract 14 hours each time, and combine the extracts; heat the extracts until all the ethanol is volatilized (no alcohol smell), add an equal volume of petroleum ether, and stir at room temperature Soak for 5 hours, then separate the upper ...

Embodiment 2

[0020] Embodiment 2 antidepressant animal simulation drug efficacy experiment

[0021] The animal antidepressant efficacy experiment was carried out with the petroleum ether extract of Ginseng variable leaves extracted with ethanol.

[0022] 1. Forced Swimming Pre-Experiment in Mice

[0023] The mice were randomly divided into 3 subgroups, namely the model group (solvent group, only experiment without administration), the fluoxetine hydrochloride group (0.02g / kg), and the high-dose group (8g / kg) treated with Ginseng variable leaf extract. kg), 3 in each group. Pre-swim for 15 minutes before the experiment, and perform the formal forced swimming pre-test 24 hours later, that is, after 30 minutes of intragastric administration of mice, place them in a 2000ml large beaker with a height of 20cm and a diameter of 14cm. The water height of the beaker is about 10cm, the water temperature is 23 ± 2 ℃, the test mice are forced to swim for 6 minutes, and the cumulative time of the mic...

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Abstract

The invention relates to application of Dendropanax proteus extract in the preparation of anti-depression natural drugs. The Dendropanax proteus extract is made by crushing stems of Dendropanax proteus, soaking the crushed stems with purified water, heating, extracting leachate with 95% ethanol, extracting the extract with 75% ethanol, extracting with petroleum ether, concentrating the liquid extract, and drying. Forced swimming test and tail suspension test of mice show that the Dendropanax proteus extract has significant anti-depression effect and good depression therapeutic effect. Long-term virulence test observation on mice shows that no abnormality occurs, and safety is good; the Dendropanax proteus extract is expectedly developable into novel anti-depression natural drugs.

Description

technical field [0001] The present invention relates to the functional research of the extract of ginseng variable leaves, in particular to the application of the extract of ginseng variable leaves in the preparation of antidepressant natural medicine. Background technique [0002] Depression is a common mental illness with many factors and the etiology is not yet clear. Due to the rapid development of the modern economy, people's quality of life is constantly improving, the pace of life is gradually accelerating, and the psychological pressure is also increasing. It has been backlogged in the heart, and it is easy to suffer from depression. The main manifestation of depression is obvious and persistent low mood, and serious thoughts and behaviors of suicide will appear. [0003] Statistics show that patients with depression have a high suicide rate. According to WHO data, about 1 million people in the world commit suicide due to depression every year. Depression affects p...

Claims

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Application Information

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IPC IPC(8): A61K36/25A61P25/24
CPCA61K36/25A61P25/24A61K2236/331A61K2236/333A61K2236/39A61K2236/55
Inventor 邹一平
Owner 珠海俊一健生物医药科技有限公司
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