pH fluorescence chemical sensor based on temperature-sensitive double hydrophilic block polymer, and synthesis method and application thereof

Abstract

The invention discloses a pH fluorescence chemical sensor based on a temperature-sensitive double hydrophilic block polymer, and a synthesis method and application thereof, belonging to the technicalfield of chemical fluorescent materials. The pH fluorescence chemical sensor PEG<113>-b-P(NIPAM-co-RhHHMa)<65> based on the temperature-sensitive double hydrophilic block polymer is synthesized in theinvention, and an acid recognition motif RhHHMa is labeled in the temperature-sensitive block of the sensor. The pH fluorescence chemical sensor is a multifunctional fluorescent chemical sensor withpH response and temperature response, and has the characteristics of excellent water solubility, biocompatibility, high sensitivity, etc. Moreover, the pH fluorescence chemical sensor can self-assemble to form an aggregate with P(NIPAM-co-RhHHMa)<65> as a core, and the pH response motif RhHHMa is embedded in the hydrophobic core, so the quantum yield of fluorescent elements is increased, which enables the amplification of signals to be realized.

Description

technical field [0001] The invention belongs to the technical field of chemical fluorescent materials, and in particular relates to a pH fluorescent chemical sensor and its synthesis method and application. Background technique [0002] The pH value is one of the most important physical and chemical parameters of an aqueous solution. All natural phenomena, chemical changes and production processes involving water and solutions are related to pH. The rapid and accurate determination of the pH value in a solution is of great research significance to many fields such as chemistry, medicine, biology, agriculture and environmental science. However, most of the existing pH measurement methods are electrochemical detection, and most of them have high impedance. , Difficult to miniaturize, easy to break, low sensitivity, limited measurement range, "sodium error" and "acid error" and other defects limit its application in intracellular pH detection and cell imaging research. [0003...

AI Technical Summary

Problems solved by technology

The rapid and accurate determination of the pH value in a solution is of great research significance to many fields such as chemistry, medicine, biology, agriculture and environmental science. However, most of the existing pH measurement methods are electrochemical detection, and most of them have high impedance. , Difficult to miniaturize, easy to break, low sensitivity, limited measurement range, "sodium error" and "acid error" and other defects limit its application in intracellular pH detection and cell imaging research

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