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Use of genistein in preparation of drugs to prevent or treat African swine fever

A technology of genistein and African swine fever, applied in the field of medicine, can solve the problems of legacy antibiotics, poor oral treatment effect, easy recurrence of disease, etc.

Inactive Publication Date: 2019-09-06
李荣立
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In recent years, although some drugs for the treatment of African swine fever have been developed, their therapeutic effects are slow, the disease is prone to relapse, and the treatment is not complete. However, African swine fever has a rapid onset, strong infectivity, and high acute mortality. Most of the animals infected with the virus It will die during the treatment process. Even if the symptoms of some infected pigs are relieved, the probability of disease recurrence is relatively high, and some drugs contain a large amount of antibiotics. After medication, a large amount of antibiotics will be left in the body
On the other hand, the traditional Chinese medicine preparations currently used to treat African swine fever have poor oral therapeutic effect, and most antibacterial active ingredients will be rapidly decomposed and metabolized by the digestive system, losing the therapeutic effect
At present, there is no rapid, thorough, efficient and safe oral drug for the treatment of African swine fever. After being infected with African swine fever, the only way to kill it immediately and isolate it is to prevent infection.

Method used

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  • Use of genistein in preparation of drugs to prevent or treat African swine fever
  • Use of genistein in preparation of drugs to prevent or treat African swine fever
  • Use of genistein in preparation of drugs to prevent or treat African swine fever

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: Preparation of genistein dry suspension

[0021] prescribing information

[0022]

[0023] Preparation:

[0024] Add genistein to 300ml ethanol, stir to dissolve, then add β-cyclodextrin and magnetically stir, then concentrate, dry, pulverize, and pass through a 120-mesh sieve; 100 mesh sieve, spare. Weigh and mix genistein inclusion compound, lactose, mannitol, sodium starch glycolate and xanthan gum according to the prescription amount, stir for more than 30 minutes, and mix evenly. Dissolve the prescribed amount of sodium saccharin and pineapple flavor in the remaining ethanol to make a binder and make a soft material. Granulate with 20-mesh sieve, dry at 55-60°C; granulate with 18-mesh sieve. Packed in composite film bags or bottles.

Embodiment 2

[0025] Embodiment 2: Preparation of genistein dry suspension

[0026] prescribing information

[0027]

[0028] Preparation:

[0029] Add genistein to 720ml ethanol, stir to dissolve, then add hydroxypropyl-β-cyclodextrin and magnetically stir, then concentrate, dry, pulverize, and pass through a 120-mesh sieve; fillers, disintegrants, auxiliary The suspension was sieved through a 100-mesh sieve and set aside. Weigh and mix genistein inclusion compound, sucrose, mannitol, hydroxypropyl starch and xanthan gum according to the prescription amount, stir for more than 30 minutes, and mix evenly. Stir and add 10% polyvinylpyrrolidone ethanol solution into the above-mentioned mixed main and auxiliary materials to make a soft material. Granulate with 20-mesh sieve, dry at 55-60°C; granulate with 18-mesh sieve. Packed in composite film bags or bottles.

Embodiment 3

[0030] Embodiment 3: the preparation of genistein dropping pill

[0031] Take 100g of polyethylene glycol 4000 according to the prescription, heat and melt it in a water bath at 80°C, add 50g of genistein under stirring, stir at 80°C to make it disperse evenly, and transfer the liquid medicine to the dropping pill machine for constant temperature storage In the material tank, the dropping speed is 60 drops / min, the coolant is liquid paraffin, and the temperature of the coolant is 15° C., the weight of the dropping pills is adjusted to 60 mg, and the dropping pills are made, and the surface coolant of the dropping pills is removed, and then subpackaged to obtain final product.

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PUM

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Abstract

The invention provides a use of genistein in the preparation of drugs to prevent or treat African swine fever, wherein when applied to the preparation of drugs to prevent African swine fever, the doseof genistein is 1-2 g per swine per day; when applied to the preparation of drugs to treat African swine fever, the dose of genistein is 2-20 g per swine per day; within a dosing period of seven days, the dose for two days ahead is 2-4 g per swine per day, and the dose for five days later is 4-20 g per swine per day. The invention also provides joint application of genistein with other ingredients in the co-preparation of pharmaceutical preparations to prevent and treat African swine fever.

Description

technical field [0001] The invention relates to a medicine use, in particular to the use of genistein in the preparation of medicines for preventing or treating African swine fever, and belongs to the technical field of medicine. Background technique [0002] Genistein is soluble in DMSO and ethanol, almost insoluble in water, the structure is as follows: [0003] [0004] Genistein is an isoflavone compound derived from legumes and dentate plants, and its chemical name is 4’,5,7-trihydroxyisoflavone. Genistein has a variety of pharmacological effects and biological activities such as preventing early atherosclerosis and chronic vascular diseases, anti-tumor, and women's climacteric syndrome. Genistein is a powerful inhibitor of tyrosine protein kinase and topoisomerase, through the regulation of oncogenes, it can inhibit tumor growth and metastasis in multiple ways. In vivo, in vitro experiments and epidemiology have shown that genistein can inhibit a variety of tumors...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61K45/06A61P31/14
CPCA61K31/352A61K45/06A61P31/14
Inventor 李荣立
Owner 李荣立
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