Composite beverage and application thereof

A composition and vitamin technology, applied in the direction of application, drug combination, plant raw materials, etc., can solve the problems of reducing lens accommodative changes, ciliary muscle disuse myasthenia, and decreased accommodative function, so as to achieve dry eye relief, Effect of reducing vascular resistance index and increasing blood flow

Inactive Publication Date: 2019-08-16
INFINITUS (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the deepening of myopia, it is often necessary to wear glasses. Although glasses can alleviate the degree of myopia, they reduce the accommodative changes of the lens. Over time, it will cause disuse weakness of the ciliary muscle and further reduce the accommodative function.

Method used

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  • Composite beverage and application thereof
  • Composite beverage and application thereof
  • Composite beverage and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-3 and comparative example 1-2

[0063]

[0064] Using the above dosage, mixing, sterilizing, filling, capping, pouring, packaging, made into 1000KG, 480mL / bottle.

Embodiment 4

[0065] Example 4 Experimental Study on the Alleviating Effect of Experimental Dry Eye Syndrome in Rabbits

[0066] 1.1 Preparation and relief test of dry eye disease model

[0067] 30 New Zealand rabbits (60 eyes), after adaptive feeding for 3 days, were randomly divided into blank control group, model control group, compound beverage low, middle and high dose groups prepared by the present invention, 6 groups of pilocarpine positive control groups, each group 5 animals. Except the blank control group, the eyes of the animals were instilled with 0.25% chloramphenicol eye drops (3 drops per eye, 2 times a day) and after feeding for 3 days, the rabbits were taken to make a dry eye model according to Xie Hanping's method: 33% Ula Tan was anesthetized by intraperitoneal injection at a dose of 1 g / kg. Fix the rabbits on the experimental table, disinfect the operation area with povidone iodine and 75% ethanol, and spread hole towels. Push the eyeball forward, look for the lacrima...

Embodiment 5

[0089] Example 5 Experimental Study on Alleviating Effects on Rabbit Retinal Ischemia Model

[0090]2.1 Experimental method: 30 New Zealand rabbits (60 eyes), after 3 days of adaptive feeding, were randomly divided into blank control group, model control group, low, middle and high dose groups of the compound beverage prepared by the present invention, and anisodamine tablets were positive There were 6 groups in the control group, with 5 animals in each group. Animals in blank control group and model control group were orally given distilled water for physical examination. The compound drink that the embodiment of the present invention 1~3 makes and the beverage that comparative examples 1~2 make are given 3.17g / kg rabbit · day by intragastric administration to the animals of the low-dose treatment group; kg rabbits per day; the high-dose treatment group was given 12.68g / kg rabbits per day by intragastric administration; the positive control group was given anisodamine 2.8mg / ...

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Abstract

The invention relates to the field of food, in particular to a composite beverage and application thereof. In particular, the invention provides a composition and application thereof in preparation ofdrugs and/or foods for preventing and/or relieving dry eye or relaxing ciliary muscles and improving retinal blood circulation. Experimental results show that the composite beverage disclosed by theinvention can be used for increasing the wet length of Schirmer I test filter paper of a dry eye model rabbit (increasing tear secretion), prolonging tear film rupture time (increasing the stability of a tear film), and reducing the number of rosebengal staining points of keratoconjunctiva (improving the eye surface protection level). The composite beverage has a relaxing effect on ciliary musclecontraction induced by acetylcholine; the blood flow of the central retinal artery in the systole and diastole can be increased, and the vascular resistance index can be reduced. Visibly, the composition and the composite beverage which are provided by the invention have an obvious relieving effect on experimental dry eye, and play a role in preventing and treating myopia by relaxing ciliary muscles and improving retinal blood circulation.

Description

technical field [0001] The invention relates to the field of food, in particular to a compound drink and its application. Background technique [0002] In modern society, the widespread use of television and computers, the increase in work pressure and life pressure, and the increase in eye use lead to more and more ophthalmic diseases such as eye fatigue and dry eye syndrome. [0003] Dry eye disease is a common eye disease in which the ocular surface epithelium dries up due to low tear secretion or abnormal tear film caused by other reasons. With the increase in the number of computer terminal workers and the emergence of population aging, the incidence of dry eye is increasing year by year. Epidemiological surveys show that more than 20% of people aged 30-40 suffer from dry eye disease, and those over 70 years old suffer from dry eye disease. The prevalence rate in the population is as high as 36.1%, and the research and prevention of dry eye disease are getting more and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/87A61P27/02A61P27/10A23L2/02A23L2/52A23L33/105A23L33/15A61K31/375A61K31/355
CPCA23L2/02A23L2/52A23V2002/00A61K31/355A61K31/375A61K36/45A61K36/815A61K36/87A23L33/105A23L33/15A61P27/02A61P27/10A61K2300/00A23V2200/30A23V2250/2106A23V2250/21A23V2250/708A23V2250/712
Inventor 罗珍李文治葛亚中赵秀婷
Owner INFINITUS (CHINA) CO LTD
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