A kind of assay method of essence narcotic drugs

A measurement method and a drug technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve problems such as the concentration error of seminal and narcotic drugs, and achieve the effect of cheap and easy-to-obtain raw materials, short time-consuming, and simple preparation process

Active Publication Date: 2021-09-28
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] Aiming at the problem that the existing sampling technology has a large error in the determination of the concentration of narcotics in water, the present invention provides a method for the determination of narcotics

Method used

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  • A kind of assay method of essence narcotic drugs
  • A kind of assay method of essence narcotic drugs
  • A kind of assay method of essence narcotic drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] In this embodiment, the above-mentioned MCX resin adsorption film is used as a binding film in the DGT technology, and the DGT technology is used to determine the presence of the narcotics in the water to be tested. The specific detection steps are as follows:

[0046] (1) Assembly of the DGT device: the MCX resin adsorption membrane, the diffusion membrane and the filter membrane are sequentially stacked between the DGT base and the cover with a window to assemble the DGT device (such as figure 1 shown), wherein the base and cover of the DGT device are made of acrylonitrile-butadiene-styrene copolymer;

[0047] (2) Placement of the DGT device: put the DGT device in step (1) into well-stirred water containing the seminal anesthetic to be tested, and place it for a certain period of time.

[0048] (3) Recovery and elution of the resin adsorption membrane: After taking the DGT device out of the water body to be tested, rinse the dirt on the surface of the device with pure...

Embodiment 2

[0057] This example is basically the same as Example 1, except that the adsorption film in this example is based on agarose film, and activated MCX resin is distributed on the surface of the agarose film, with a particle size of 30-40 μm.

[0058] The preparation steps of adsorption membrane in the present embodiment are as follows:

[0059] (1) Activate the MCX resin with methanol, wash it with ultrapure water, and set aside;

[0060] (2) Agar powder, activated MCX resin (wet weight) and pure water are mixed according to the mass ratio of 1:8:50 according to the added mass ratio, shake up and heat the solution to boiling to make it transparent to obtain the MCX resin agar solution;

[0061] (3) Inject the agar solution of the prepared MCX resin into the gap between two glass plates sandwiched with U-shaped Teflon material sheets, extrude the air bubbles between the glass plates, place the glass plates horizontally and cool them at room temperature for 80min, the glass The s...

Embodiment 3

[0065] This embodiment is basically the same as Embodiment 1, the difference is only in:

[0066] In step (1), the specific steps for MCX resin to be activated using methanol are as follows:

[0067] 1) Methanol activation: add 50g of MCX resin to 70mL of methanol solvent, soak for 30min, then centrifuge at 5000r / min for 5min, remove the supernatant, and obtain a deposited solid;

[0068] 2) Cleaning with ultra-pure water: add pure water to the deposited solid for shock treatment, centrifuge at a speed of 5000r / min for 5 minutes, remove the supernatant, and wash with ultra-pure water three times to obtain activated MCX resin;

[0069] 3) Preservation: Add ultrapure water to the activated MCX resin again, and the amount added is such that the liquid level exceeds the MCX resin and can be stored.

[0070] Using the above steps, the MCX resin can be activated and then distributed in the agarose film to prepare the corresponding adsorption film. The adsorption membrane of this e...

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Abstract

The invention discloses a method for measuring narcotics and narcotics. A DGT device is used to measure narcotics and narcotics in water, and an MCX resin adsorption film is prepared by using MCX resin with a particle diameter of 30-40 μm and an agarose film. The membrane is applied to the technology based on the gradient diffusion thin film (DGT), and a suitable diffusion membrane and filter membrane are selected; after the adsorption is completed, a suitable eluent is selected to eliminate the measurement error of the seminal drugs to the greatest extent; the raw materials of the present invention are cheap It is easy to obtain, the preparation process is simple and time-consuming, and it is suitable for the in-situ detection of narcotics in water.

Description

technical field [0001] The invention relates to the technical field of gradient diffusion films, and more specifically relates to a method for determining anesthesia drugs. Background technique [0002] Sperm and anesthetic drugs are a class of drugs that can directly act on the central nervous system to achieve excitatory or inhibitory effects. With the acceleration of the pace of life and the increase of life pressure in modern society, the incidence of mental diseases is gradually increasing, and the consumption of seminal drugs is also increasing. At present, narcotics and narcotics are widely detected in various water bodies around the world, including influent water from sewage plants, surface water, groundwater, seawater, and even drinking water (Wu M. , et al., Chemosphere, 2015, 138, 486-493). Studies have shown that exposure to narcotics can directly affect the central nervous system and disrupt neuroendocrine, and long-term trace exposure will pose a serious thr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/08
CPCG01N30/02G01N30/08
Inventor 罗军方舟李渊
Owner NANJING UNIV
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