Method for measuring concentration of molecular targeted drugs in plasma by using ultra-high performance liquid chromatography tandem mass spectrometry
An ultra-high performance liquid chromatography and tandem mass spectrometry technology, which is applied in the field of ultra-high performance liquid chromatography tandem mass spectrometry to determine the concentration of plasma molecular targeted drugs, and achieves the effects of strong specificity, good reproducibility and high sensitivity
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[0034] 1 solution preparation
[0035] The volumes and weights used to prepare solutions can be adjusted proportionally, and all solutions are stored at room temperature unless otherwise stated.
[0036] 1.1 Preparation of mobile phase solution
[0037] Organic phase (A): Methanol containing 0.2% formic acid and 5 mM ammonium acetate by mass fraction.
[0038] Aqueous phase (B): water containing 0.2% formic acid and 5 mM ammonium acetate by mass fraction.
[0039] Mobile phase selection: In order to meet the requirements of low quantitative detection range in the experiment, we investigated the organic phase (such as methanol, acetonitrile, etc.) and aqueous phase in various commonly used mobile phases, and tried to add different proportions of solution enhancers (such as 0.01 % formic acid, 0.05% formic acid, 0.2% formic acid, 0.01% acetic acid, 2mM ammonium formate, 5mM ammonium formate, 2mM ammonium acetate, etc.). It was found that when formic acid was added to the orga...
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