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Technology for preparing L(+)-tartaric acid through coupling process

A technology of tartaric acid and sodium tartrate, which is applied in the direction of fixing on/in organic carriers, fermentation, etc., can solve the problems of high fermentation intensity, inability to use immobilized cells, and high production cost, and achieve good storage stability and save fermentation The effect of high raw material cost and high mechanical strength

Pending Publication Date: 2019-08-02
安徽海蓝生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The advantage of this process is that it uses lower-priced calcium carbonate instead of soda ash. The concentration of the ionized liquid can reach more than 40%, and the concentration strength is small. However, this process cannot use immobilized cells, and calcium tartrate can be directly obtained through enzymatic conversion. Fermentation Too strong and expensive to prepare enzymes

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A kind of coupling method prepares the technique of L (+)-tartaric acid, comprises the following steps:

[0024] (1) Preparation of calcium cis-epoxysuccinate, using maleic anhydride as a raw material, reacting with calcium carbonate under the action of a tungsten-containing catalyst, and producing cis-calcium epoxysuccinate through hydrogen peroxide oxidation; summary of this example The tungsten-containing catalyst is sodium tungstate dihydrate.

[0025] Specifically: Measure 500mL (500g) of water, add 98g of maleic anhydride, 50g of calcium carbonate, 139mL (152.9g) of 27.5% hydrogen peroxide, and 2g of sodium tungstate dihydrate in sequence. Add 50g of calcium carbonate, cool down to 30°C, filter and wash with water to obtain cis-calcium epoxysuccinate and mother liquor, 257g of cis-calcium epoxysuccinate and 450mL of mother liquor after drying.

[0026] The mother liquor can also be recycled: add 50mL water to the mother liquor, add 98g maleic anhydride, 50g calci...

Embodiment 2

[0035] A kind of coupling method prepares the technique of L (+)-tartaric acid, comprises the following steps:

[0036] (1) Preparation of calcium cis-epoxysuccinate, using maleic anhydride as a raw material, reacting with calcium carbonate under the action of a tungsten-containing catalyst, and producing cis-calcium epoxysuccinate through hydrogen peroxide oxidation; summary of this example The tungsten-containing catalyst is sodium tungstate dihydrate.

[0037] Specifically: Measure 500mL of water, add 90g of maleic anhydride, 45g of calcium carbonate, 150g of 27.5% hydrogen peroxide, and 1.8g of sodium tungstate dihydrate in sequence, control the temperature at 60°C, keep warm for 2 hours, then add 45g of calcium carbonate, After cooling down to 28°C, filter and wash with water to obtain cis-calcium epoxysuccinate and mother liquor, 238g of cis-calcium epoxysuccinate and 435mL of mother liquor after drying.

[0038]The mother liquor can also be recycled: add 45mL water to ...

Embodiment 3

[0047] A kind of coupling method prepares the technique of L (+)-tartaric acid, comprises the following steps:

[0048] (1) Preparation of calcium cis-epoxysuccinate, using maleic anhydride as a raw material, reacting with calcium carbonate under the action of a tungsten-containing catalyst, and producing cis-calcium epoxysuccinate through hydrogen peroxide oxidation; summary of this example The tungsten-containing catalyst is sodium tungstate dihydrate.

[0049] Specifically: Measure 500mL of water, add 105g of maleic anhydride, 55g of calcium carbonate, 155g of 27.5% hydrogen peroxide, and 2.2g of sodium tungstate dihydrate in sequence, control the temperature at 75°C, keep warm for 4 hours, then add 55g of calcium carbonate, cool After cooling down to 30°C, filter and wash with water to obtain calcium cis-epoxysuccinate and mother liquor, 259 g of calcium cis-epoxysuccinate after drying, and 450 mL of mother liquor.

[0050] The mother liquor can also be recycled: add 55mL...

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Abstract

The invention relates to the technical field of tartaric acid preparation and especially relates to a technology for preparing L(+)-tartaric acid through a coupling process. The technology comprises the following steps: preparing cis-epoxy calcium succinate by taking maleic anhydride as a raw material, reacting with calcium carbonate under the effect of a tungsten-containing catalyst and oxidizingwith hydrogen peroxide; preparing sodium tartrate by taking immobilized cells as a biocatalyst and enzymatically converting disodium cis-epoxysuccinate into sodium tartrate; coupling replacement: heating a sodium tartrate solution and then mixing with cis-epoxy calcium succinate, measuring the content of tartaric acid in supernate, and filtering when the content of tartaric acid does not declineany more, thereby acquiring solid calcium tartrate and filtrate; acidizing by adding sulfuric acid into the calcium tartrate, thereby acquiring L(+)-tartaric acid. According to the invention, the problem of high fermentation strength in the traditional preparation process is solved by using the immobilized cells and adopting the mode of coupling replacement, and the technology is water-saving andenvironment-friendly and is high in production benefit.

Description

technical field [0001] The invention relates to the technical field of tartaric acid preparation, in particular to a process for preparing L(+)-tartaric acid by a coupling method. Background technique [0002] L(+)-tartaric acid is a natural organic acid, which has a high content in grapes. L(+)-tartaric acid can be used as one of food additives, flavor enhancers and food coloring components. It is also an important raw material in the pharmaceutical industry. Many insoluble drugs can be processed into tartrate salts with excellent water solubility. Cosmetics, brewing, construction, electroplating, tanning and other industries have a wide range of uses. In the early days, L(+)-tartaric acid was mainly extracted from tartar, a by-product of wine. Due to the limitation of raw materials, the output could not meet the demand. In recent years, the main production technology of L(+)-tartaric acid is the calcium carbonate synthesis method: first synthesize cis-epoxycalcinate calc...

Claims

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Application Information

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IPC IPC(8): C12P7/46C12N11/10C12N11/02
CPCC12N11/02C12N11/10C12P7/46
Inventor 蒋先荣
Owner 安徽海蓝生物科技有限公司
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