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Double-drug release PMMA compound bone cement and preparation method thereof

A bone cement and dual-drug technology, applied in the preparation of dual-drug release PMMA composite bone cement, in the field of dual-drug release PMMA composite bone cement, can solve the problem of low drug release rate of drug-loaded PMMA bone cement and inability to release drugs in stages and other problems, to achieve the effect of good application prospects, low cost, and high drug release rate

Active Publication Date: 2019-08-02
XIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a dual-drug release PMMA composite bone cement, which solves the problems that the drug-loaded PMMA bone cement prepared by the prior art has a low drug release rate and cannot be released in stages.

Method used

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  • Double-drug release PMMA compound bone cement and preparation method thereof
  • Double-drug release PMMA compound bone cement and preparation method thereof

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preparation example Construction

[0043] The preparation method of the above-mentioned dual-drug release PMMA composite bone cement, the specific steps are as follows:

[0044] Step 1. Prepare gelatin-drug solution and oil phase, then mix gelatin-drug solution and oil phase, heat and stir, cool, then add glutaraldehyde, freeze-dry after stirring to obtain osteoporosis drug-loaded gelatin with porous surface Microspheres;

[0045] Step 1.1, add osteoporosis medicine into deionized water and stir to dissolve to obtain osteoporosis medicine solution, the mass concentration of osteoporosis medicine in deionized water is 0.02g / mL~0.1g / mL, osteoporosis medicine is A lendronate or risedronate;

[0046] Step 1.2, heating and stirring the gelatin and the osteoporosis drug solution prepared in step 1.1 under the condition of 45°C to 55°C until they are evenly mixed to obtain a gelatin-drug solution, wherein the mass ratio of gelatin to osteoporosis drug solution is 1 to 5 :20;

[0047] Step 1.3: Mix Span-80 and liqui...

Embodiment 1

[0058] Step 1. Prepare gelatin-drug solution and oil phase, then mix gelatin-drug solution and oil phase, heat and stir, cool, then add glutaraldehyde, freeze-dry after stirring to obtain osteoporosis drug-loaded gelatin with porous surface Microspheres;

[0059] Step 1.1, add the osteoporosis drug alendronate sodium into deionized water and stir to dissolve to obtain the osteoporosis drug solution, the mass concentration of the osteoporosis drug in the deionized water is 0.02g / mL;

[0060] Step 1.2, heating and stirring the gelatin and the osteoporosis drug solution prepared in step 1.1 at 50° C. until mixed uniformly to obtain a gelatin-drug solution, wherein the mass ratio of gelatin and osteoporosis drug solution is 1:20;

[0061] Step 1.3: Mix Span-80 and liquid paraffin at a volume ratio of 1:100, and then stir at 50°C until evenly mixed to obtain an oil phase;

[0062] Step 1.4. Add the gelatin-drug solution prepared in step 1.2 dropwise to the oil phase in step 1.3, t...

Embodiment 2

[0072] Step 1. Prepare gelatin-drug solution and oil phase, then mix gelatin-drug solution and oil phase, heat and stir, cool, then add glutaraldehyde, freeze-dry after stirring to obtain osteoporosis drug-loaded gelatin with porous surface Microspheres;

[0073] Step 1.1, add the osteoporosis drug risedronate sodium into deionized water and stir to dissolve to obtain the osteoporosis drug solution, the mass concentration of the osteoporosis drug in the deionized water is 0.1g / mL;

[0074]Step 1.2, heating and stirring the gelatin and the osteoporosis drug solution prepared in step 1.1 at 55° C. until mixed uniformly to obtain a gelatin-drug solution, wherein the mass ratio of gelatin and osteoporosis drug solution is 5:20;

[0075] Step 1.3: Mix Span-80 and liquid paraffin at a volume ratio of 3:100, and then stir at 55°C until evenly mixed to obtain an oil phase;

[0076] Step 1.4, add the gelatin-drug solution prepared in step 1.2 dropwise to the oil phase in step 1.3, the...

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Abstract

The invention discloses a double-drug release PMMA compound bone cement and a preparation method thereof. The preparation method comprises the following steps: firstly, preparing a surface porous osteoporosis drug-loading gelatin microsphere; loading an antibiotic drug onto the surface porous osteoporosis drug-loading gelatin microsphere, thereby acquiring a double-drug loaded gelatin microsphere;uniformly mixing the double-drug loaded gelatin microsphere with solid PMMA bone cement powder, thereby acquiring a solid phase of double-drug loaded PMMA compound bone cement; mixing the solid phasepowder of double-drug release PMMA compound bone cement with a PMMA bone cement liquid-phase reagent, thereby acquiring the double-drug release PMMA compound bone cement. In the double-drug release PMMA compound bone cement prepared according to the invention, the gelatin microsphere with double-drug loaded on interior and exterior is added into the solid phase; the staging release of double drugis realized; the double-drug release PMMA compound bone cement is antibacterial and anti-inflammation, has a certain curative effect to osteoporosis, is low-cost, has no special requirement for production equipment and has an excellent application prospect in clinic.

Description

technical field [0001] The invention belongs to the technical field of medical biomaterial preparation, and relates to a dual-drug release PMMA composite bone cement, and also relates to a preparation method of a dual-drug release PMMA composite bone cement. Background technique [0002] With the aging of the population, the number of people suffering from osteoporosis is gradually increasing, and the incidence of vertebral compression fractures caused by osteoporosis is also increasing, which is generally treated by vertebral body filling surgery. PMMA, polymethyl methacrylate bone cement, has been invented for more than 50 years. It has been widely used in clinical oral cavity, orthopedic surgery, and orthopedic surgery. It has good mechanical properties and good tissue compatibility. The most widely used bone cement material in surgery. However, infection problems may occur after surgery. Once infection occurs, wound healing may be delayed in mild cases, and osteomyeliti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/16A61L27/22A61L27/54
CPCA61L27/16A61L27/222A61L27/54A61L2430/02A61L2300/216A61L2300/622A61L2300/45C08L33/12
Inventor 汤玉斐查祥赵康李超峰陈磊曹怡
Owner XIAN UNIV OF TECH
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