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A kind of gynecological foam agent and preparation method thereof

A foam agent and gynecological technology, which is applied in the direction of anti-inflammatory agent, antiviral agent, pharmaceutical formula, etc., can solve the problems of low separation and removal efficiency of curcumol, limitation, and inability to make good use of medicinal value, so as to strengthen the anti-inflammatory effect. Anti-tumor and anti-pathogenic microorganisms, long-lasting, anti-human papilloma virus effect

Active Publication Date: 2021-07-30
YUAN INT GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent CN 102363019A discloses a warm curcuma oil extract and its preparation method and application. The prepared curcuma oil can be used to prepare various medicines, but the separation and removal efficiency of curcumol is not high, which makes the extract There may be a certain anti-fertility effect, and there are certain restrictions in the preparation of drugs for the treatment of related diseases of women of childbearing age, and its medicinal value cannot be well utilized

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The preparation of turmeric oil extract comprises the following steps:

[0046] (a) get zedoary, pulverize, cross 40 mesh sieves;

[0047] (b) Add ethanol and propylene glycol with a volume ratio of 4:1 as a modifier according to 20% of the mass of Zedoary Curcuma, carry out supercritical carbon dioxide extraction for 25 minutes at a temperature of 60°C and a pressure of 12mpa, collect the extract with ethanol or propylene glycol, and filter got residue;

[0048] (c) Add 5 times of purified water to the residue, and steam distill at 125° C. for 2.5 hours; to obtain the steam distillation extract, mix the extract and the steam distillation extract to obtain zedoary oil;

[0049] (d) rectifying and separating the zedoary oil, collecting a solid-liquid mixed fraction at a temperature of 170-180°C under a pressure of 3-5kpa;

[0050] (e) Filtrate the solid-liquid mixed fraction to remove the solid component to obtain a filtrate, and mix the filtrate with the remaining fra...

Embodiment 2

[0057] The preparation of turmeric oil extract comprises the following steps:

[0058] (a) get zedoary, pulverize, cross 30 mesh sieves;

[0059] (b) add ethanol and propylene glycol according to 10% of the quality of Zedoary Curcuma and add the volume ratio of ethanol and propylene glycol is 3: 1 to make modifying agent, temperature 60 ℃, under pressure 10mpa, carry out supercritical carbon dioxide extraction 20min, collect extract with ethanol or propylene glycol, filter to obtain residue;

[0060] (c) Add 3 times of purified water to the residue, and steam distill at 120° C. for 2 hours; obtain the steam distillation extract, mix the extract and the steam distillation extract to obtain zedoary oil;

[0061] (d) rectifying and separating the zedoary oil, collecting a solid-liquid mixed fraction at a temperature of 170-180°C under a pressure of 3-5kpa;

[0062] (e) Filtrate the solid-liquid mixed fraction to remove the solid component to obtain a filtrate, and mix the filtr...

Embodiment 3

[0069] The preparation of turmeric oil extract comprises the following steps:

[0070] (a) get turmeric, pulverize, and cross a 50-mesh sieve;

[0071] (b) Adding ethanol and propylene glycol according to 25% of the quality of Zedoary Curcuma is 5:1 as a modifier, at a temperature of 65° C., under a pressure of 15 mpa, carry out supercritical carbon dioxide extraction for 30 min, collect the extract with ethanol or propylene glycol, and filter to obtain residue;

[0072] (c) Add 6 times of purified water to the residue, and steam distill at 130° C. for 3 hours; obtain the steam distillation extract, mix the extract and the steam distillation extract to obtain zedoary oil;

[0073] (d) rectifying and separating the zedoary oil, collecting a solid-liquid mixed fraction at a temperature of 170-180°C under a pressure of 3-5kpa;

[0074] (e) Filtrate the solid-liquid mixed fraction to remove the solid component to obtain a filtrate, and mix the filtrate with the remaining fractio...

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Abstract

The invention belongs to the technical field of gynecological pharmacy, and specifically relates to a gynecological foaming agent and a preparation method thereof. , purified water, etc., the zedoary oil extract is combined with supercritical carbon dioxide extraction and steam distillation, and controls the changes of important parameters such as solvent, temperature, and pressure in the extraction process, and the curcumol in zedoary Efficiently extracted, the curcuma oil extract after removing curcumol is used to prepare gynecological foam, which can better inhibit gynecological diseases, enhance women's body immune function, improve female endocrine and improve safety.

Description

technical field [0001] This field belongs to the technical field of gynecology pharmaceuticals, and in particular relates to a gynecology foam and a preparation method thereof. Background technique [0002] Gynecological diseases such as vaginitis are usually some common frequently-occurring diseases, which usually cannot be cured for a long time, which brings great inconvenience to normal life and work. Clinically, vaginitis is mainly characterized by changes in leucorrhea and itching and burning pain in the vulva. Pain during sexual intercourse is also common. When the infection involves the urethra, there may be symptoms such as dysuria and urgency. Vaginitis has a slow onset and strong recurrence. Difficult to treat completely. At present, local and systemic antibiotics and azole antifungal drugs are mostly used in the clinical treatment of vaginitis. The curative effect is positive, but vaginitis is very easy to relapse. Patients with recurrent vaginitis need to take a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61K9/12A61K47/10A61P31/02A61P31/04A61P31/10A61P31/12A61P15/02A61P29/00A61P15/00A61P33/02A61P35/00A61P31/20A61P17/04A61P37/04A61P5/00A61P15/08C11B9/02A61K31/155
CPCA61K9/0034A61K9/122A61K31/155A61K36/9066A61K47/10A61K2236/331A61K2236/37A61P5/00A61P15/00A61P15/02A61P15/08A61P17/04A61P29/00A61P31/02A61P31/04A61P31/10A61P31/12A61P31/20A61P33/02A61P35/00A61P37/04C11B9/022C11B9/025C11B9/027A61K2300/00
Inventor 王若研田德海张军史跃满黄炎冯雪陈晓彤李建石佳袁一鸣何爱琳王翼超刘爽
Owner YUAN INT GROUP
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