A kind of two-photon fluorescent carbon dot material and its synthesis method and application

Abstract

The disclosure provides a two-photon fluorescent carbon dot material and its synthesis method and application. It is a spherical carbon dot material containing hydrazide groups on the surface, and the spherical carbon dot material is composed of the main chain of at least one polymer molecule under the action of hydrogen bonds. Formed by folding and winding, the structural formula of the polymer is as follows: wherein, the number average molecular weight of the polymer is 10 3 ~10 7 The preparation method is to use benzoyl hydrazide as a raw material, and adopt a hydrothermal method to prepare two-photon fluorescent carbon dot materials in one step. There are a large number of hydrazine groups on the surface of the polymer carbon dot material of the present disclosure, which will induce light-induced intramolecular electron transfer to quench autofluorescence. After reacting with malondialdehyde, the PET process is inhibited and the fluorescence is restored, thereby achieving Detection of malondialdehyde.

Description

technical field [0001] The disclosure relates to a two-photon fluorescent carbon dot material, a synthesis method and an application. Background technique [0002] The statements herein merely provide background information related to the present disclosure and may not necessarily constitute prior art. [0003] Brain tissue is characterized by high oxygen consumption and low antioxidant capacity, and compared with other tissues, it is susceptible to oxidative stress, which in turn triggers lipid peroxidation. Malondialdehyde, as a typical active carbonyl species, is an important biomarker of lipid peroxidation. Malondialdehyde is easily cross-linked with protein or nucleic acid, which can irreversibly damage brain cells and lead to brain diseases such as Alzheimer's disease and Parkinson's syndrome. However, the mechanism of MDA-mediated brain pathophysiology remains unclear. Therefore, it is first necessary to develop reliable materials to accurately track MDA in living ...

AI Technical Summary

Problems solved by technology

The inventors of the present disclosure have found through research that the complex biological background of the brain itself, coupled with the protection of the blood-brain barrier, leads to the fact that this type of probe cannot realize the specific real-time monitoring of brain malondialdehyde, and the synthesis cost of the probe is high and the structure Complexity, poor performance, and cumbersome process, these shortcomings limit the development of brain malondialdehyde imaging materials

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