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Method for simultaneously improving degradation rate and biological activity of iron-based implants

A technology of degradation rate and biological activity, which is applied in the field of biomedical implant design and manufacturing, can solve the problems of poor biological activity and slow degradation of iron-based implants, and achieve reduced mechanical properties, good biocompatibility and, The effect of accelerating bone healing

Inactive Publication Date: 2019-06-25
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problems of slow degradation and poor biological activity of iron-based implants, the present invention proposes a method for synchronously improving the degradation rate and biological activity of iron-based implants

Method used

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  • Method for simultaneously improving degradation rate and biological activity of iron-based implants
  • Method for simultaneously improving degradation rate and biological activity of iron-based implants
  • Method for simultaneously improving degradation rate and biological activity of iron-based implants

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Using calcium sulfate powder (3-10 μm in particle size) and iron powder (30-40 μm in particle size) as raw materials, weigh 8 g of calcium sulfate powder and 92 g of iron powder at a mass ratio of 8:92; The powder and calcium sulfate powder were mechanically stirred and mixed for 30 minutes, and then stirred and ball-milled for 100 minutes to obtain a uniformly dispersed iron-calcium sulfate mixed powder; the above-mentioned uniformly dispersed iron-calcium sulfate mixed powder was used as raw material, and selective laser melting was used as the process , the laser power is 100W, the laser spot diameter is 0.1mm, the scanning speed is 50mm / s, and the iron-based implant is obtained after being melted and solidified under the protection of argon.

[0046] Implementation effect: The prepared iron-based implant was tested, and it was found that calcium sulfate was evenly dispersed in the iron matrix. After soaking in human simulated body fluid for 20 days, the calculated de...

Embodiment 2

[0048] Using calcium sulfate powder (3-10 μm in particle size) and iron powder (30-40 μm in particle size) as raw materials, weigh 3 g of calcium sulfate powder and 97 g of iron powder at a mass ratio of 3:97; The powder and calcium sulfate powder were mechanically stirred and mixed for 30 minutes, and then stirred and ball-milled for 100 minutes to obtain a uniformly dispersed iron-calcium sulfate mixed powder; the above-mentioned uniformly dispersed iron-calcium sulfate mixed powder was used as raw material, and selective laser melting was used as the process , the laser power is 100W, the laser spot diameter is 0.1mm, the scanning speed is 50mm / s, and the iron-based implant is obtained after being melted and solidified under the protection of argon.

[0049] Implementation effect: The prepared iron-based implant was tested, and it was found that calcium sulfate was uniformly dispersed in the iron matrix. After soaking in human simulated body fluid for 20 days, the calculated...

Embodiment 3

[0051] Using calcium sulfate powder (3-10 μm in particle size) and iron powder (30-40 μm in particle size) as raw materials, weigh 8 g of calcium sulfate powder and 92 g of iron powder at a mass ratio of 8:92; The powder and calcium sulfate powder were mechanically stirred and mixed for 30 minutes, and then stirred and ball-milled for 100 minutes to obtain a uniformly dispersed iron-calcium sulfate mixed powder; the above-mentioned uniformly dispersed iron-calcium sulfate mixed powder was used as raw material, and selective laser melting was used as the process , the laser power is 120W, the laser spot diameter is 0.1mm, the scanning speed is 50mm / s, and the iron-based implant is obtained after being melted and solidified under the protection of argon.

[0052] Implementation effect: The prepared iron-based implant was tested and found that calcium sulfate was uniformly dispersed in the iron matrix. After the iron-based implant prepared by this method was soaked in human simula...

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Abstract

The invention relates to a method for simultaneously improving the degradation rate and biological activity of iron-based implants, which belongs to the technical field of biomedical implant design and manufacturing. A scheme is characterized in that iron powder and calcium sulfate are used as raw materials, through an alternative laser melting process, an iron-based implant is obtained, and the iron-based implant comprises the following components in mass percentage: 0.5-12% of calcium sulfate; and 88-99.5% of iron. The method solves the problem that the conventional iron-based implant degrades too slowly, and controls the degradation rate within a reasonable range; in addition, the calcium sulfate can form a bone-like apatite layer by degradation, forms good bone bonding with the tissue,and increases the biological activity of the iron-based implant. At the same time, the method can realize the uniform dispersion of calcium sulfate in an iron matrix and maintain the structural integrity by optimizing the preparation process, and fully exerts the effect of improving the degradation behavior and biological activity of the iron-based implant.

Description

technical field [0001] The invention relates to a method for synchronously improving the degradation rate and biological activity of iron-based implants, and belongs to the technical field of design and manufacture of biomedical implants. Background technique [0002] Recently, researchers have proposed absorbable and degradable iron as a material for human bone repair, which is easily corroded in a humid environment, which is considered biodegradable in medicine. Iron-based implants can gradually degrade in the body along with the gradual recovery of bone tissue, which avoids the need for surgical removal of traditional metal implants after bone tissue recovery, and patients suffer less pain, recover quickly, and have fewer sequelae. In terms of biocompatibility, iron is an important trace element in the human body. It can combine with hemoglobin and play an important role in mechanisms such as oxygen transport and enzyme reactions. At the same time, it can also affect the ...

Claims

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Application Information

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IPC IPC(8): A61L27/02A61L27/04A61L27/50A61L27/58C23C24/10
Inventor 高成德帅词俊王丽
Owner CENT SOUTH UNIV
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