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Preparation method of antibacterial chitosan and application of antibacterial chitosan as liquid care dressing

An antibacterial shell and polysaccharide technology, which is applied in the preparation of antibacterial materials and the field of antibacterial chitosan preparation, can solve the problems of complex preparation process and difficult to meet the needs of use, and achieve simple preparation steps, good antibacterial effect, and excellent antibacterial performance effect

Inactive Publication Date: 2019-06-21
青岛溯博生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation process of this method is complicated, and it is prepared through multi-step reactions such as quaternization reaction, chloroacetylation reaction, and quaternization reaction, and the prepared product has an inhibitory effect on fungi, which is difficult to meet the needs of use

Method used

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  • Preparation method of antibacterial chitosan and application of antibacterial chitosan as liquid care dressing
  • Preparation method of antibacterial chitosan and application of antibacterial chitosan as liquid care dressing
  • Preparation method of antibacterial chitosan and application of antibacterial chitosan as liquid care dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A kind of preparation method of antibacterial chitosan, comprises the steps:

[0027] 1) Stir and dissolve 50 mL of chitosan hydrochloride aqueous solution with a mass fraction of 3%;

[0028] 2) Add 3 g of 4-dimethylbutylamine to the solution in the previous step, then add 2 g of 1,3-dibromopropane, and stir at 60 °C for 72 h;

[0029] 3) After the reaction, alternately wash three times with ethanol and cyclohexane, and vacuum dry to obtain antibacterial chitosan;

[0030] Utilize above-mentioned antibacterial chitosan to prepare the preparation method of chitosan liquid antibacterial care dressing, comprise the steps:

[0031] Dissolve 1 g of antibacterial chitosan in 90 mL of deionized water, add 5 g of glycerin, 2 g of Moutan bark extract and 2 g of dandelion extract, and stir mechanically for 1 h to obtain chitosan liquid antibacterial nursing dressing .

Embodiment 2

[0033] A kind of preparation method of antibacterial chitosan, comprises the steps:

[0034] 1) Stir and dissolve 50 mL of chitosan lactate aqueous solution with a mass fraction of 2%;

[0035] 2) Add 3 g of 6-dimethylhexylamine to the solution in the previous step, then add 2 g of 1,4-dibromobutane, and stir at 70 °C for 48 h;

[0036] 3) After the reaction, wash with ethanol and methanol four times, and dry in vacuum to obtain antibacterial chitosan;

[0037] Utilize above-mentioned antibacterial chitosan to prepare the preparation method of chitosan liquid antibacterial care dressing, comprise the steps:

[0038] Dissolve 1 g of antibacterial chitosan in 90 mL of deionized water, add 5 g of glycerin, 2 g of Artemisia argyi leaf extract and 2 g of Usnea barbadensis extract, and stir mechanically for 1 h to obtain chitosan liquid antibacterial care dressing.

Embodiment 3

[0040] A kind of preparation method of antibacterial chitosan, comprises the steps:

[0041] 1) Stir and dissolve 100 mL of chitosan lactate aqueous solution with a mass fraction of 1%;

[0042] 2) Add 2 g of 4-dimethylaminobutylamine and 2 g of tri-n-hexylamine to the solution in the previous step, and then add 1 g of 1,5-dibromopentane and 1 g of 1,6-dibromohexane, Stir the reaction at 80 °C for 36 h;

[0043] 3) After the reaction, wash with methanol and petroleum ether four times, and dry in vacuum to obtain antibacterial chitosan;

[0044] Utilize above-mentioned antibacterial chitosan to prepare the preparation method of chitosan liquid antibacterial care dressing, with embodiment 1.

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Abstract

The invention discloses a preparation method of antibacterial chitosan. The preparation method comprises the steps as follows: adding a short alkyl chain tertiary amine reagent and a halogenation reagent to a chitosan solution for a quaternization reaction and a coupling reaction simultaneously to obtain antibacterial chitosan; dissolving the obtained antibacterial chitosan in water, adding plantextract and glycerol to prepare the antibacterial liquid care dressing. The antibacterial liquid care dressing can be used for wound cleaning and disinfection, is antibacterial and antiinflammatory, and protects wound surface.

Description

technical field [0001] The invention relates to a preparation method of an antibacterial material and its application as a liquid nursing dressing, in particular to a preparation method of an antibacterial chitosan and its application as a liquid nursing dressing, and belongs to the field of biomedical materials. Background technique [0002] Bacterial and fungal infections are the main cause of common skin conditions, and the overuse of antibiotics has led to the emergence of a large number of drug-resistant bacteria. Safe and efficient antibacterial materials can not only effectively kill harmful bacteria, but also are not easy to produce drug resistance, and have no side effects on the human body, which is a hot research topic at present. [0003] Chitosan is an alkaline polysaccharide obtained by deacetylation of chitin, which has excellent properties such as biological functionality and compatibility, blood compatibility, safety and microbial degradability, and is widel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08A61L26/00
Inventor 罗旭杨毅胡杨
Owner 青岛溯博生物技术有限公司
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