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Voglibose orally disintegrating tablet and preparation method thereof

A technology for voglibose and orally disintegrating tablets, which is applied to the field of voglibose orally disintegrating tablets and their preparation, can solve the problems of affecting the therapeutic effect of drugs, slow disintegration, long drug dissolution time, etc., and achieve industrial application Good outlook, no gritty, good taste effect

Inactive Publication Date: 2019-06-21
王广生
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the problem of voglibose at home and abroad is that the disintegration is slow, and the dissolution time of the drug is long, which affects the therapeutic effect of the drug.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1 (making 1000 pieces)

[0032] Prescription: voglibose 34g, lactose 48.5g, pregelatinized starch 30g, microcrystalline cellulose 18g, L-hydroxypropyl cellulose 15g, aspartame 1.5g, micronized silica gel 1.5g, water 118.8g, Magnesium stearate 1.5g.

[0033] Preparation process: Mix the prescription amount of lactose, pregelatinized starch, microcrystalline cellulose, L-hydroxypropyl cellulose, aspartame and micropowder silica gel with the prescription amount of voglibose, add the prescription amount Water granulation, drying, sizing, and finally adding the prescribed amount of magnesium stearate and mixing, determining the weight and hardness of the tablet, and pressing the tablet to obtain the orally disintegrating voglibose tablet. The whole preparation process is completed at 25°C.

[0034] Appearance: The orally disintegrating voglibose tablets prepared by this method are off-white with a smooth surface.

[0035] In vitro disintegration: Take 1 tablet ...

Embodiment 2

[0037] Embodiment 2 (making 1000 pieces)

[0038] Prescription: voglibose 17g, lactose 65.5g, pregelatinized starch 30g, microcrystalline cellulose 18g, L-hydroxypropyl cellulose 15g, aspartame 1.5g, micronized silica gel 1.5g, water 118.8g, Magnesium stearate 1.5g.

[0039] Preparation process: Mix the prescription amount of lactose, pregelatinized starch, microcrystalline cellulose, L-hydroxypropyl cellulose, aspartame and micropowder silica gel with the prescription amount of voglibose, add the prescription amount Water granulation, drying, sizing, and finally adding the prescribed amount of magnesium stearate and mixing, determining the weight and hardness of the tablet, and pressing the tablet to obtain the orally disintegrating voglibose tablet. The whole preparation process is completed at 25°C.

[0040] Appearance: The orally disintegrating voglibose tablets prepared by this method are off-white with a smooth surface.

[0041] In vitro disintegration: Take 1 tablet ...

Embodiment 3

[0043] Embodiment 3 (making 1000 pieces)

[0044] Prescription: voglibose 8.5g, lactose 74g, pregelatinized starch 30g, microcrystalline cellulose 18g, L-hydroxypropyl cellulose 15g, aspartame 1.5g, micronized silica gel 1.5g, water 118.8g, Magnesium stearate 1.5g.

[0045] Preparation process: Mix the prescription amount of lactose, pregelatinized starch, microcrystalline cellulose, L-hydroxypropyl cellulose, aspartame and micropowder silica gel with the prescription amount of voglibose, add the prescription amount Water granulation, drying, sizing, and finally adding the prescribed amount of magnesium stearate and mixing, determining the weight and hardness of the tablet, and pressing the tablet to obtain the orally disintegrating voglibose tablet. The whole preparation process is completed at 25°C.

[0046] Appearance: The orally disintegrating voglibose tablets prepared by this method are off-white with a smooth surface.

[0047]In vitro disintegration: Take 1 tablet of...

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Abstract

The invention relates to voglibose for treating type 2 diabetes mellitus, in particular to a voglibose orally disintegrating tablet and a preparation method thereof, and belongs to the field of medicinal preparation research. A surface shape of the voglibose orally disintegrating tablet is smooth, bright and clean, splitting and sticking tablets are omitted, and the tablets cannot be split in thetransportation process. When the voglibose orally disintegrating tablet is clinically applied, auxiliary water drinking in an oral cavity is omitted, rapidly disintegrating can be achieved, sandy gravel feeling is omitted, and taste is good. The dissolution rate of the orally disintegrating tablet in dilute hydrochloric acid solution reaches 90% or more. The preparation method is simple, low in energy consumption and suitable for industrial mass production, and a lot of production can be achieved without special devices. The voglibose orally disintegrating tablet is low in production cost andlabor cost, controlling and monitoring of particular or special conditions are omitted, and industrial application prospects are good.

Description

technical field [0001] The invention relates to voglibose, a medicine for treating type II diabetes, in particular to voglibose orally disintegrating tablets and a preparation method thereof, belonging to the field of pharmaceutical preparation research. Background technique [0002] Diabetes is an endocrine and metabolic disease characterized by elevated blood sugar. It is a chronic disease that plagues the world. At present, there are about 230 million patients in the world. It is estimated that the number of diabetic patients will increase to 300 million by 2025. Type Ⅱ Diabetes usually occurs after the age of 35 to 40, accounting for more than 90% of diabetic patients. With the improvement of living standards, the incidence rate among children also has a rising trend in recent years. Type Ⅱ diabetes has become a common frequently-occurring disease after tumors and cardiovascular and cerebrovascular diseases, and its drug market is expanding year by year. [0003] Voglib...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/133A61K9/20A61P3/10
Inventor 王广生
Owner 王广生
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