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A red blood cell backlog correction method and storage medium

A correction method and hematocrit technology, which are applied in the field of hematocrit correction methods and storage media, can solve the problems of large test errors of blood glucose test strips, and achieve the effect of reducing blood glucose test errors and reducing correction steps

Active Publication Date: 2021-05-14
WUHAN J H BIO TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The object of the present invention is to provide a red blood cell backlog correction method and a storage medium, which are used to solve the problem of large test errors of blood glucose test strips at different temperatures in the prior art

Method used

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  • A red blood cell backlog correction method and storage medium
  • A red blood cell backlog correction method and storage medium
  • A red blood cell backlog correction method and storage medium

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Experimental program
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Embodiment 1

[0033] In this embodiment, two variables of temperature and hematocrit are used to compensate the reading of blood glucose concentration. Firstly, venous whole blood with a hematocrit of 20%, 30%, 42%, 55% and 70% was respectively prepared, and the concentration of each hematocrit vein was respectively prepared at 2.8mmol / L, 5.6mmol / L, and 13.9mmol / L, 19.4mmol / L, 25.0mmol / L, 33.3mmol / L whole blood samples, the numerical calibration process in this example is calibrated by a fully automatic biochemical analyzer. Then, test the above 30 venous whole blood samples sequentially at ambient temperatures of 5°C, 15°C, 25°C, 35°C and 45°C respectively, repeat the test 10 times for the same blood sample at the same temperature, and calculate the average value to obtain The test temperature T measured by the blood glucose meter 0 , the electrical signal AD value related to the hematocrit, and the test current I related to the blood sugar concentration 0 , the test results are shown i...

Embodiment 2

[0084] In this embodiment, two variables of temperature and current are used to compensate the reading of blood glucose concentration. Firstly, the hematocrit of venous whole blood was prepared to be 42%±2%, and blood glucose concentrations of 2.8mmol / L, 5.6mmol / L, 9.4mmol / L, 15.3mmol / L, and 27.8mmol / L were respectively prepared. sample. Then, the above-mentioned 7 venous whole blood samples were sequentially tested at ambient temperatures of 5°C, 15°C, 25°C, 35°C and 45°C, and the same blood sample was tested 10 times at the same temperature, and the average value was calculated to obtain The test temperature T measured by the blood glucose meter 0 , and the test current I related to the blood glucose concentration 0 , the test results are shown in Table 9 and Table 10:

[0085] Table 13 Test current I 0 surface

[0086]

[0087]

[0088] Table 14 Test temperature T 0 surface

[0089]

[0090] Execute the above step S2 to set the reference temperature T C =25...

Embodiment 3

[0098] In this embodiment, two variables of current and hematocrit are used to compensate the reading of blood glucose concentration. First, set the test temperature to three constant temperature values ​​of 10°C, 25°C, and 40°C, and the positive and negative fluctuations of the temperature do not exceed 2°C. 30%, 42%, 55%, 70%, and the blood of each hematocrit was configured into 2.8mmol / L, 6.1mmol / L, 19.4mmol / L, 33.3mmol / L blood samples. Then, test the above-mentioned blood samples at three constant temperatures, repeat the test 10 times for each blood sample, and obtain a series of AD values ​​and test current I 0 Value, execute step S1, according to the test circuit amplification operation logic, convert the AD value into the sample resistance value R related to the hematocrit Hct, and according to the correlation equation y=k between the sample resistance value R and the hematocrit Hct 1 *x 2 +k 2 *x+k 3 , calculate the initial hematocrit value Hct 0 value, where y i...

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Abstract

The invention discloses a red blood cell backlog correction method. The steps include: applying a voltage to a sample, and recording the test temperature, the AD value of the hematocrit and the test current, converting the AD value into a sample resistance value, and passing the sample resistance value and the correlation equation of the hematocrit value is calculated to obtain the initial hematocrit value; determine the reference temperature and the reference hematocrit value, and obtain the temperature difference and the hematocrit difference; The hematocrit difference is brought into the compensation factor equation to obtain the compensation factor; the current value and the compensation factor are brought into the current correction equation to obtain the corrected current; the corrected current is brought into the blood glucose concentration equation to obtain the blood glucose concentration correction value. The invention reduces the correction steps of the blood sugar test through the method for correcting the backlog of red blood cells, and significantly reduces the error of the blood sugar test.

Description

technical field [0001] The invention relates to the field of blood sugar testing, in particular to a red blood cell backlog correction method and a storage medium. Background technique [0002] At present, the blood glucose test strips that use electrochemical methods on the market are mostly based on the detection of redox reactions between glucose oxidase or glucose dehydrogenase solidified on the blood glucose test strips and glucose in the measured blood samples. The size of the microcurrent is used to determine and display the concentration of glucose in the blood sample. This method is considered to be effective and accurate, but due to environmental factors and blood sample itself factors will lead to large deviations in test results, especially temperature and hematocrit (Hematocrit, referred to as Hct) have a particularly significant impact on test results. The operating temperature of blood glucose test strips is usually between 10°C and 40°C. Different ambient te...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/416
Inventor 王健斌龚贻洲许俊峰李强
Owner WUHAN J H BIO TECH
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