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Water-soluble chitosan with thermosensitive characteristic and preparation method therefor

A technology of water-soluble chitosan and sensitive characteristics, applied in the field of water-soluble chitosan and its preparation, can solve the problems of slow temperature response speed of hydrogel, low solubility of modified chitosan, and difficulty in forming gel , to achieve the effects of good biocompatibility, simple preparation method and fast response speed

Inactive Publication Date: 2019-06-07
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The currently reported water-soluble chitosan macromolecules mainly use small molecules to graft chitosan macromolecules. The modified chitosan molecules prepared by this method have poor solubility when the grafting rate is low, and are not easy to form coagulation when the grafting rate is high. glue, in addition, the formed hydrogels respond slowly to temperature, which limits their applications in the fields of medicine and biology

Method used

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  • Water-soluble chitosan with thermosensitive characteristic and preparation method therefor
  • Water-soluble chitosan with thermosensitive characteristic and preparation method therefor
  • Water-soluble chitosan with thermosensitive characteristic and preparation method therefor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] 1) Take 1.5g of chitosan powder, 1.75g ​​of N-isopropylacrylamide, 0.075g of ammonium persulfate with a viscosity-average molecular weight of 65w and a degree of deacetylation of 90%, and disperse them in 95 milliliters of deionized water, then, Add 0.2mL of hydrochloric acid, stir and dissolve evenly, react at 60°C for 8 hours, then use deionized water to dialyze the reaction product to neutrality, and vacuum freeze-dry to obtain poly-N-isopropylacrylamide modified chitosan powder ;

[0020] 2) Weigh 1.0 g of the poly-N-isopropylacrylamide modified chitosan powder obtained in step 1), disperse it in 25 milliliters of deionized water, stir and dissolve to obtain poly-N-isopropylacrylamide modified chitosan powder with a mass concentration of 4%. Propylacrylamide modified chitosan aqueous solution;

[0021] 3) Pour the poly-N-isopropylacrylamide-modified chitosan aqueous solution configured in step 2) into the mold, and then place the mold in a water bath at 35° C. for ...

Embodiment 2

[0027] 1) Take 1.5g of chitosan powder, 1.75g ​​of N-isopropylacrylamide, 0.075g of ammonium persulfate with a viscosity-average molecular weight of 65w and a degree of deacetylation of 90%, and disperse them in 95 milliliters of deionized water, then, Add 0.2mL of hydrochloric acid, stir and dissolve evenly, react at 60°C for 8 hours, then use deionized water to dialyze the reaction product to neutrality, and vacuum freeze-dry to obtain poly-N-isopropylacrylamide modified chitosan powder ;

[0028] 2) Weigh 1.5g of the poly-N-isopropylacrylamide modified chitosan powder obtained in step 1), disperse it in 30 milliliters of deionized water, stir and dissolve to obtain poly-N-isopropylacrylamide modified chitosan powder with a mass concentration of 5%. Propylacrylamide modified chitosan aqueous solution;

[0029] 3) Pour the poly-N-isopropylacrylamide-modified chitosan aqueous solution configured in step 2) into the mold, and then place the mold in a water bath at 35° C. for 1...

Embodiment 3

[0031] 1) Take 1.5g of chitosan powder, 1.75g ​​of N-isopropylacrylamide, 0.075g of ammonium persulfate with a viscosity-average molecular weight of 65w and a degree of deacetylation of 90%, and disperse them in 95 milliliters of deionized water, then, Add 0.2mL of hydrochloric acid, stir and dissolve evenly, react at 60°C for 8 hours, then use deionized water to dialyze the reaction product to neutrality, and vacuum freeze-dry to obtain poly-N-isopropylacrylamide modified chitosan powder ;

[0032] 2) Weigh 1.2g of the poly-N-isopropylacrylamide modified chitosan powder obtained in step 1), disperse it in 20 milliliters of deionized water, stir and dissolve to obtain poly-N-isopropylacrylamide modified chitosan powder with a mass concentration of 6%. Propylacrylamide modified chitosan aqueous solution;

[0033] 3) Pour the poly-N-isopropylacrylamide-modified chitosan aqueous solution configured in step 2) into the mold, and then place the mold in a water bath at 35° C. for 1...

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Abstract

The invention discloses water-soluble chitosan with thermosensitive characteristic and a preparation method therefor. According to the method, chitosan macromolecules are modified with N-isopropyl acrylamide, and the poly-N-isopropyl acrylamide modified chitosan, which is good in water solubility and has thermosensitive characteristic, is prepared through an emulsion polymerization method. PNipam-CS molecules prepared by the method have good water solubility, can keep a solution state at a low temperature and can rapidly form aquagel when a temperature is close to a human physiology temperature. According to the water-soluble chitosan and the preparation method therefor, both a chitosan unit and a poly-N-isopropyl acrylamide unit in an aquagel structure have excellent biocompatibility andare free of stimulation to skin, tissue, eyes and the like, so that the thermosensitive gel has a broad application prospect in the fields of medicinal, biological and medical materials of biochemicalseparation, cell culture, drug controlled-release systems, tissue engineering, dressings, skin repair and the like.

Description

technical field [0001] The invention relates to a modified chitosan macromolecule and its hydrogel, in particular to a water-soluble chitosan with temperature-sensitive properties and a preparation method thereof. Background technique [0002] Chitosan is an amino polysaccharide derived from nature. Its macromolecular chain is composed of acetylglucosamine and deacetylglucosamine through random or block distribution. It has good biocompatibility, blood compatibility, hemostatic performance, antibacterial Performance and natural drug activity, can promote wound healing, can be degraded by lysozyme in vivo, the final degradation product is glucosamine, which is weakly alkaline, consistent with the pH value of body fluids, and can be absorbed by the body. field has great application potential. my country's chitosan production is abundant and easy to obtain. However, the utilization of chitosan is still very low so far. The main reason is that the processing performance of chit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F251/00C08F220/54C08J3/075C08L51/02
Inventor 胡巧玲董晓飞王征科姜质琦姚远
Owner ZHEJIANG UNIV
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