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Eucalyptus oil doxycycline hydrochloride self-microemulsion for livestock and preparation method and application of eucalyptus oil doxycycline hydrochloride self-microemulsion

A technology of doxycycline hydrochloride and eucalyptus oil hydrochloride is applied in the field of veterinary eucalyptus oil doxycycline hydrochloride self-microemulsion and its preparation, which can solve the problems of serious occurrence of respiratory diseases and poor treatment effect, and achieves Prevention and treatment of poultry respiratory diseases and chronic respiratory diseases, improved solubility, and low production costs

Active Publication Date: 2019-06-07
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved in the present invention is to overcome the problem that the existing poultry has serious respiratory diseases in the breeding process, and the existing drug treatment effect is not good, and a kind of veterinary eucalyptus oil doxycycline hydrochloride self-microemulsion is provided, It can be administered by aerosol or spray to prevent and treat poultry respiratory diseases and chronic respiratory diseases

Method used

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  • Eucalyptus oil doxycycline hydrochloride self-microemulsion for livestock and preparation method and application of eucalyptus oil doxycycline hydrochloride self-microemulsion
  • Eucalyptus oil doxycycline hydrochloride self-microemulsion for livestock and preparation method and application of eucalyptus oil doxycycline hydrochloride self-microemulsion
  • Eucalyptus oil doxycycline hydrochloride self-microemulsion for livestock and preparation method and application of eucalyptus oil doxycycline hydrochloride self-microemulsion

Examples

Experimental program
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Effect test

Embodiment 1

[0043] Example 1 Preparation of 5% Veterinary Eucalyptus Oil Doxycycline Hydrochloride Self-Microemulsion

[0044] Take by weighing 50g doxycycline hydrochloride crude drug, 0.2g butyl p-hydroxyanisole (BHA), join in the N-pyrrolidone of 49.8g, stir and dissolve to obtain solution a, for subsequent use;

[0045] Take by weighing 360g Tween-80 and 240g absolute ethanol and mix on a shaker, then add 300g eucalyptus oil, then add solution a, stir and mix with a magnetic stirrer to obtain 5% eucalyptus oil doxycycline hydrochloride prime self-microemulsion, adjust the pH to 4.0, and set aside.

Embodiment 2

[0046] Example 2 Preparation of 10% Veterinary Eucalyptus Oil Doxycycline Hydrochloride Self-Microemulsion

[0047]Take by weighing 100g doxycycline hydrochloride crude drug, 0.5g tert-butylhydroquinone (TBHQ), join in the α-pyrrolidone of 80.5g, stir and dissolve to obtain solution a, for subsequent use;

[0048] Take by weighing 326g Tween-80 and 216g 1,2-propanediol and mix on a shaker, then add 277g eucalyptus oil, then add solution a, stir and mix with a magnetic stirrer to obtain 10% eucalyptus oil hydrochloride Cycycline self-microemulsion, adjust the pH to 4.0, and set aside.

Embodiment 3

[0049] Example 3 Preparation of 20% Veterinary Eucalyptus Oil Doxycycline Hydrochloride Self-Microemulsion

[0050] Take by weighing 200g doxycycline hydrochloride crude drug, 0.3g butylated hydroxytoluene (BHT), join in the N-N dimethylformamide of 149.7g, stir and dissolve to obtain concentrated solution a, set aside;

[0051] Take by weighing 260g polyoxyethylene hydrogenated castor oil EL-35 and 175g n-butanol and mix on a shaker, then add 215g eucalyptus oil, then add concentrated solution a, stir and mix with a magnetic stirrer to obtain 20% eucalyptus Leaf oil doxycycline hydrochloride self-microemulsion, adjusted to pH 4.0, set aside.

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Abstract

The invention provides a eucalyptus oil doxycycline hydrochloride self-microemulsion g for livestock and a preparation method and application of the eucalyptus oil doxycycline hydrochloride self-microemulsifon. The self-microemulsion comprises the following components in proportion of 50-250 g / L of doxycycline hydrochloride raw drugs, 1-50 g / L of a solvent, 0.1-2 g / L of an antioxidant, 80-300 g / La surfactant, 60-300 g / L an assistance surfactant, and 100-450 g / L of an oil phase. The self-microemulsion is good in stability, uniform in particle size distribution, and good in dispersibility. Eucalyptus oil is used as the oil phase of a phase converting method, and the problem of dissolving of folium eucalypti essential oil is solved. Besides, the eucalyptus oil has mild stimulation effects onrespiratory tract nasal cavity and endotracheal mucosa, can promote mucus secretion and can dredge logged nasal cavity and logged bronchus. In addition, the self-microemulsion is simple in preparation method, mild in condition, and low in production cost, can be used for preparing medicines or feed additives for livestock, and has high economic value and biology promotion value.

Description

technical field [0001] The invention belongs to the field of veterinary preparations. More specifically, it relates to a veterinary eucalyptus oil doxycycline hydrochloride self-microemulsion and its preparation method and application. Background technique [0002] Doxycycline Hydrochloride (Doxycycline Hydrochloride, also known as doxycycline hydrochloride) is a light blue or yellow crystalline powder, odorless, bitter, hygroscopic, with broad-spectrum antibacterial drugs, mainly for bacteria, mycoplasma, Erythrocytic diseases, chlamydia, rickettsia and other infections are used for respiratory tract infections, chronic bronchitis, and acute and chronic respiratory diseases, such as nasal discharge, tearing, mouth breathing and tracheal rales, etc., in the treatment of respiratory tract has been very widely used. However, doxycycline is not stable enough under acidic and alkaline conditions and is prone to hydrolysis. Under acidic conditions, the hydroxyl group on C-6 of...

Claims

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Application Information

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IPC IPC(8): A61K36/61A61K9/107A61K47/10A61K47/26A61K47/44A61P11/00A61P31/04A23K10/30A23K20/195A61K31/65
Inventor 黄显会冯云云邱阳阳耿昊宇杜刘宝廖晓萍
Owner SOUTH CHINA AGRI UNIV
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