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Application of traditional Chinese medicine composition in preparation medicament for treating upper airway cough syndrome

A technology of composition and syndrome, which is applied in the field of application of traditional Chinese medicine composition in the preparation of drugs for treating upper airway cough syndrome, can solve the problems of increasing the refractory and recurrent nature of the disease, and achieve easy operation and preparation method Simple, portable effect

Active Publication Date: 2019-05-31
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, a series of irreversible pathological changes such as tissue stasis, edema, thickening, vascular proliferation, infiltration of lymphocytes and plasma cells, and shedding of epithelial cilia increase the refractory and recurrent nature of this disease.

Method used

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  • Application of traditional Chinese medicine composition in preparation medicament for treating upper airway cough syndrome
  • Application of traditional Chinese medicine composition in preparation medicament for treating upper airway cough syndrome
  • Application of traditional Chinese medicine composition in preparation medicament for treating upper airway cough syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The preparation of embodiment 1 Chinese medicine compound oral liquid

[0023] Goat horn 94.5g was shredded, hydrolyzed and refluxed twice with alkaline aqueous solution, the filtrate was combined twice, and concentrated; 15.75g kelpite and 23.62g gypsum were crushed into coarse powder, heated and decocted twice, filtered, and the two filtrates were combined. The second filtrate was concentrated to a relative density of 1.01 to 1.04 (75°C to 85°C); artificial bezoar 9.45g was extracted twice with 70% ethanol under reflux, filtered, and the two filtrates were combined, and the ethanol was recovered under reduced pressure and concentrated to a relative density of 1.02~1.05 (75°C~85°C); the remaining four herbs, 47.25g of Fritillaria, 31.5g of Rhubarb, 15.75g of Scutellaria, and 31.5g of Licorice, were decocted twice with water, filtered, and the two filtrates were combined and concentrated to the relative Density 1.10 (85°C), centrifuge, add ethanol to the supernatant to ...

Embodiment 2

[0025] Embodiment 2 Chinese medicine compound oral liquid anti-inflammatory activity

[0026] 1. Experimental materials

[0027] 1.1 Cell lines

[0028] The mouse macrophage cell line RAW 264.7 was purchased from the Shanghai Cell Bank of the Chinese Academy of Sciences.

[0029] 1.2 Drugs and reagents

[0030] DMEM / HIGH GLUCOSE, Gibco, Lot: 8118035;

[0031] FBS: Hyclone, Lot: SH30084.03;

[0032] LPS: Nanjing Dazhi Biotechnology Co., Ltd.;

[0033] DMSO: Aladdin, lot number: D1712055;

[0034] 0.25% Trypsin-EDTA: Gibco, Lot: 1697785;

[0035] NO detection kit: Biyuntian, product number: S0021;

[0036] Mouse IL-6 detection kit: invitrogen, Lot: 1913800020;

[0037] Mouse TNF-α detection kit: invitrogen, Lot: 184786017;

[0038] Mouse PGE2 detection kit: Enzo Life Sciences, Lot: 08211709C.

[0039] 1.3 Experimental Instruments

[0040] CO 2 Cell incubator: thermofisher company;

[0041] Nikon TS100 Inverted Microscope: Nikon;

[0042] Ultra-clean workbench: Suzh...

Embodiment 3

[0062] Example 3 Study on the Activity of Chinese Medicine Compound Oral Liquid in Inhibiting Sputum Secretion

[0063] 1. Experimental materials

[0064] 1.1 Cell lines

[0065] NCI-H292 cells were purchased from the Shanghai Cell Bank of the Chinese Academy of Sciences.

[0066] 1.2 Drugs and reagents

[0067] Poly I:C: sigma, Lot: P9582;

[0068] Trypsin with 0.25% EDTA: Gibco, Lot: 25200072;

[0069] RPMI 1640 medium: Gibco, Lot: C11875500BT;

[0070] Fetal bovine serum: hyclone, Lot: SH30084.03;

[0071] Human MUC5AC ELISA Kit: Shanghai Sangon Biotech, Lot: C505562-0096.

[0072] 1.3 Experimental Instruments

[0073] CO 2 Cell incubator: Thermofisher;

[0074] CO 2 Cell incubator: thermofisher company;

[0075] Nikon TS100 Inverted Microscope: Nikon;

[0076] Ultra-clean workbench: Suzhou Aikelin Purification Equipment Co., Ltd.;

[0077] Pipette: eppendorf company;

[0078] Microplate reader: MD Company (M2e type).

[0079] 2. Experimental method

[0080]...

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Abstract

The invention provides application of a traditional Chinese medicine composition in preparation a medicament for treating upper airway cough syndrome. The traditional Chinese medicine composition is characterized by comprising, 5-15 parts of antelope horn or 50-150 parts of goat horn, 10-60 parts of fritillary bulb, 15-60 parts of rheum officinale, 7-30 parts of radix scutellariae, 7-30 parts of chlorite schist, 10-50 parts of gypsum, 5-20 parts of artificial bezoar, and 15-60 parts of licorice root. The compound combination medicine for treating upper airway cough syndrome can significantly inhibit the production of inflammatory factors of macrophage RAW 264.7 induced by LPS; and can significantly inhibit the secretion of mucin MUC5AC in respiratory epithelial cells stimulated by PolyI:C.In rats with upper airway cough syndrome, the traditional Chinese medicine composition can reduce an inflammatory state score of rats and reduce the levels of inflammatory factors IL-8 and TNF-a in serum.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to the application of a traditional Chinese medicine composition in the preparation of medicines for treating upper airway cough syndrome (abbreviated as UACS). Background technique [0002] Upper airway cough syndrome refers to that the secretions produced by upper respiratory diseases flow back into the nasopharynx, oropharynx, and hypopharynx through the choana, and even spread downward to the glottis or trachea, stimulating cough receptors and causing clinical symptoms. The syndrome with chronic cough as the main symptom, the common feature is that nasal secretions increase abnormally and drip back to the mucous membrane of the throat, which stimulates the cough receptors here and causes coughing. Typical clinical manifestations are: 1. Paroxysmal or persistent cough, mainly during the daytime, less coughing after falling asleep; 2. Most patients are accompanied by b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8966A61P11/14A61K35/32A61K33/26A61K33/06A61K35/413
Inventor 肖伟徐君曹泽彧许治良曹亮王振中
Owner JIANGSU KANION PHARMA CO LTD
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