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Flexible up-conversion green light sensor for living body and preparing method of sensor

A sensor and green light technology, applied in the field of biotechnology and materials, can solve the problems of weakening luminous efficiency, large metabolic burden of living body, high demand, and achieve high scientific research application prospects, high green light conversion efficiency, and high biological safety.

Inactive Publication Date: 2019-05-28
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Usually, complex surface modification methods are used to reduce its biological toxicity, such as citric acid surface modification, polyethylene glycol coating surface, etc., and excessive modification of up-conversion materials will affect its photon yield and greatly reduce the weaken its luminous efficiency; secondly, the up-conversion is gradually metabolized in the body through long-term blood circulation or body fluid circulation, and the commonly used method is multiple injections. large metabolic burden

Method used

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  • Flexible up-conversion green light sensor for living body and preparing method of sensor
  • Flexible up-conversion green light sensor for living body and preparing method of sensor
  • Flexible up-conversion green light sensor for living body and preparing method of sensor

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Effect test

Embodiment 1

[0027] Fabrication of flexible up-conversion green light sensors for in vivo applications

[0028] Pre-lay a layer of polyester film on a glass sheet, configure a 10:1 polydimethylsiloxane precursor, and mix in green light-emitting up-conversion microrods doped with rare earth erbium element 10mg / ml, negative pressure 0.03MPa Vacuumize for 30 minutes to remove air bubbles, and evenly spin-coat the mixture on the polyester film. After the liquid film is 0.2mm thick, solidify in a vacuum at 80°C for 30 minutes. After it cools down, lay a layer of polyester film on the top layer to avoid air bubbles ( figure 1 ).

Embodiment 2

[0030] Fabrication of flexible up-conversion green light sensors for in vivo applications

[0031] Pre-lay a layer of polyester film on a glass sheet, configure a polydimethylsiloxane precursor with a ratio of 9:1, and mix in green light-emitting up-conversion microrods doped with rare earth erbium element 10mg / ml, negative pressure 0.03 Vacuum at MPa for 40 minutes to remove air bubbles, and evenly spin-coat the mixture on the polyester film. After the liquid is formed into a film of 1mm, it is cured at 80°C for 40 minutes at a high temperature. After cooling, lay a layer of polyester film on the top layer to avoid air bubbles.

Embodiment 3

[0033] Fabrication of flexible up-conversion green light sensors for in vivo applications

[0034] Pre-lay a layer of polyester film on a glass sheet, configure a polydimethylsiloxane precursor with a ratio of 7:1, and mix it with green light-emitting up-conversion microrods doped with rare earth erbium element 100mg / ml, negative pressure 0.03 Vacuum at MPa for 40 minutes to remove air bubbles, and evenly spin-coat the mixture on the polyester film. After the liquid is formed into a film of 3mm, it is cured at 80°C for 60 minutes at a high temperature. After cooling, lay a layer of polyester film on the top layer to avoid air bubbles.

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Abstract

The invention discloses a flexible up-conversion green light sensor for a living body and a preparing method of the sensor. The flexible up-conversion green light sensor includes the following steps of firstly, preparing and representing a green light transmission up-conversion micro-rod doped with a rare earth erbium element; secondly, preparing a flexible up-conversion green light sensor. The second step includes the substeps of firstly, laying a polyester thin film on a glass thin plate in advance, preparing a polydimethylsiloxane precursor with different ratios of 10:1 to 7:1, mixing the green light transmission up-conversion micro-rod with the concentration of 10-100 mg / ml doped with the rare earth erbium element in the precursor, conducting vacuumizing for 30-40 min at the negative pressure of 0.03-0.05 MPa, removing bubbles, and evenly and rotationally coating the polyester thin film with the mixture; secondly, forming a film with the thickness of 0.2-3 mm with liquid, and conducting vacuum high-temperature curing for 30-60 min at 80 DEG C; thirdly, conducting close pressing after the film is cooled so that bubbles can be prevented. The prepared flexible up-conversion greenlight sensor for the living body has the area of 25 mm<2> to 1 cm<2>, bright green light with the wavelength of 540 nm can be transmitted under the excitation of near infrared light with the wavelength of 980 nm, and the flexible up-conversion green light sensor can be embedded in subcutaneous tissue of the living body and has high green light conversion efficiency and low biotoxicity.

Description

technical field [0001] The invention belongs to the field of biotechnology and material technology, and in particular relates to a flexible up-conversion green light sensor for a living body and a preparation method thereof. Background technique [0002] Up-conversion luminescent material is a material that absorbs long-wavelength light and emits short-wavelength light. Because of its long excitation light wavelength (980nm) and good tissue penetration, it is widely used in the treatment of living diseases , signaling pathway regulation, etc. The application methods of up-conversion materials in vivo mainly include local injection and tail vein injection, but both methods have limitations. First of all, the up-conversion material is composed of rare earth metals, and the safety of its application in living bodies needs to be carefully considered. Usually, complex surface modification methods are used to reduce its biological toxicity, such as citric acid surface modificati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01J1/00C09K11/85B82Y20/00B82Y40/00
Inventor 王汉杰潘惠卓常津马宁杨淳
Owner TIANJIN UNIV
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