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Application of 2'-fucosyllactose

A technology of fucosyllactose and lactoglobulin, applied in the field of biomedicine, can solve the problems of high cost of industrialized production, difficult to obtain, unclear function and the like

Active Publication Date: 2021-02-19
NORTHEAST AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although breast milk is rich in human milk oligosaccharides, they are not commonly used as food components, mainly because their functions are unclear, difficult to obtain, and high cost of industrial production

Method used

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  • Application of 2'-fucosyllactose
  • Application of 2'-fucosyllactose
  • Application of 2'-fucosyllactose

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1. Establishment of animal models

[0022] BALB / c mice were raised for one week to adapt to the environment after they were purchased. There were 10 mice in each group, and they were divided into 5 experimental groups, namely the control group, the allergy group (Allergy), and the 2'-FL intervention group (2'-FL( H): 600mg / kg, 2'-FL(M): 400mg / kg, 2'-FL(L): 200mg / kg). The 2'-FL intervention group was intragastrically administered three times a week, while the control group and the allergic group (Allergy) were intragastrically administered the same amount of normal saline. Except for the control group. Each group was injected intraperitoneally with 0.2mL allergen (1mL Freund's adjuvant + 1mL 1mg / mLβ-Lg) on ​​the 7th, 14th and 21d respectively, and the mice in the normal group were injected with the same amount of normal saline. On the 28th day, they were challenged with 5mgβ-Lg for the last time, and sacrificed 1h later to collect serum, colon and other tissues.

[00...

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PUM

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Abstract

The invention discloses the application of 2'-fucosyllactose and belongs to the technical field of biomedicine. The new application is the application of 2'-fucosyllactose in the preparation of drugs for alleviating or adjuvant treatment of allergic reactions induced by β-lactoglobulin. ‑Application of lactoglobulin-induced allergic reactions in health food, 2'‑fucosyllactose in the preparation of foods that can relieve allergic reactions induced by β‑lactoglobulin. The present invention discovers for the first time that 2'-fucosyllactose has the effect of relieving the allergic reaction induced by β-lactoglobulin, and can be used to alleviate the allergic reaction induced by β-lactoglobulin.

Description

technical field [0001] The invention relates to the application of 2'-fucosyllactose and belongs to the technical field of biomedicine. Background technique [0002] Food allergy is a major disease affecting human health. Studies have found that 5% of adults and 8% of children worldwide suffer from food allergy. Because of its rich nutrition, cow's milk has become an important food protein source for infants and young children, but at the same time, cow's milk can easily cause food allergies in infants and young children. β-lactoglobulin (BLG) is one of the main allergen proteins in milk. Milk allergy seriously endangers children's health and has aroused widespread concern around the world. The current treatment strategy for food allergy is still mainly to exclude the allergenic food, but this method is not effective and will largely limit the nutritional intake of infants or children. [0003] According to the World Health Organization's global strategy on infant and you...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/702A61P37/08A23L33/125A23L21/10A23C9/156
Inventor 李春刘丽波刘婷婷陈晓倩杜鹏李艾黎杨玉琢
Owner NORTHEAST AGRICULTURAL UNIVERSITY
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