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Assembled biological micro-tissue

A micro-tissue and biological technology, used in medical science, prostheses, coatings, etc., can solve the problems of lack of replacement organs, incomparable size and lifespan with natural organs, etc., to enhance compatibility and mechanics Performance, good functional effect

Active Publication Date: 2019-05-07
HUNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although most products are not completely artificial organs and tissues, they do not yet have all the functions of replacing organs, and they cannot compare with natural organs in terms of size and lifespan.

Method used

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Embodiment Construction

[0021] Below in conjunction with implementing regulation this patent is described further.

[0022] 1) Fabrication method of the layered stent: the bottom stent uses polycaprolactone (PCL) as the base material, and dissolves the polycaprolactone at a concentration of 7% in a mixed solution of dimethylformamide and tetrahydrofuran with a volume ratio of 4:1 During the process, fully stir for 6 hours, and use 3D printing to orderly print the polycaprolactone solution into filaments through computer programming. The diameter range of the filaments is between 10-100 μm, and the internal pore diameter of the stent is controlled between 1-10 μm. The middle and upper brackets use polylactic acid-alkyd copolymer (PLGA) as the base material. The polylactic acid-alkyd copolymer is dissolved in a single solution of dimethylformamide at a concentration of 10%, and it is fully stirred for 6 hours; Three-dimensional modeling analysis, design the spatial structure of the scaffold, manufactur...

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Abstract

In response to frequent occurrence of diseases in modern society, many tissues and organs of many patients face different degrees of failure under attack of diseases. Demands for repair and replacement of clinical pathological tissues and organs are increasing, and reconstruction of artificial tissues and organs becomes an urgent problem to be solved. The present invention discloses an assembled biological micro-tissue. Aiming at field of tissue engineering, different materials are used to produce a hydrogel-coated layered stent having different porosity and structures and capable of supporting a plurality of cells, the assembled biological micro-tissue can simulate composition of specific biological tissues, conducts artificially controlled assembly and molding, achieves three-dimensionalculture of cells and living tissues in vitro, and provides a potential solution for tissue engineering and artificial organ repair and reconstruction.

Description

technical field [0001] This patent is aimed at the field of tissue engineering and medical repair. By using different materials to make a layered scaffold that can be coated with hydrogel with different porosity and structure and can load a variety of cells, it can simulate the composition of specific biological tissues and be artificially controllable. It can be assembled and shaped to realize the three-dimensional culture of cells and living tissues outside the body, which provides new means for tissue engineering and artificial organ reconstruction. Background technique [0002] With the development of the economy, the acceleration of the pace of life, and the frequent occurrence of diseases in modern society, many patients face various degrees of failure of various tissues and organs under the attack of pain. The demand for repair and replacement of clinical diseased tissues and organs continues to increase. The repair and reconstruction of tissue has become an urgent pr...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/18A61L27/34A61L27/28A61L27/50A61L27/52A61L27/56A61L27/58
Inventor 谭志凯黄瑞英谭拥军
Owner HUNAN UNIV
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